Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHGA
  • Mouse genes Chga
  • Rat genes Chga
  • Zfish genes chga
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chga

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Chga	IPI	UniProtKB:P00441	Mouse	MGI:MGI:3614764|PMID:16369483
Molecular Function	GO:0005515	protein binding	Chga	IPI	PR:P01193	Mouse	PMID:16219686
Molecular Function	GO:0005515	protein binding	Chga	IPI	PR:P47867	Mouse	PMID:16219686
Molecular Function	GO:0005515	protein binding	Chga	IPI	RGD:621209	Rat	PMID:12388744|RGD:6906913
Cellular Component	GO:0042583	chromaffin granule	Chga	IDA		Rat	PMID:19372204|RGD:2315552
Cellular Component	GO:0005615	extracellular space	Chga	IDA		Rat	PMID:12873792|RGD:6907048
Cellular Component	GO:0098992	neuronal dense core vesicle	Chga	IDA		Rat	PMID:29166604|RGD:15023486
Cellular Component	GO:0048471	perinuclear region of cytoplasm	CHGA	IDA		Human	PMID:20862257
Cellular Component	GO:0030141	secretory granule	Chga	IDA		Rat	PMID:12388744|RGD:6906913
Biological Process	GO:0086030	adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation	Chga	IDA		Rat	PMID:22459152|RGD:6906968
Biological Process	GO:0050829	defense response to Gram-negative bacterium	CHGA	IDA		Human	PMID:15723172
Biological Process	GO:0050830	defense response to Gram-positive bacterium	CHGA	IDA		Human	PMID:15723172
Biological Process	GO:0045576	mast cell activation	CHGA	IDA		Human	PMID:21214543
Biological Process	GO:0002551	mast cell chemotaxis	CHGA	IDA		Human	PMID:21214543
Biological Process	GO:0043303	mast cell degranulation	CHGA	IDA		Human	PMID:21214543
Biological Process	GO:0033604	negative regulation of catecholamine secretion	CHGA	IDA		Human	PMID:15326220
Biological Process	GO:1901215	negative regulation of neuron death	Chga	IDA		Rat	PMID:21537909|RGD:6906969
Biological Process	GO:0006996	organelle organization	Chga	IMP		Rat	PMID:12438143|RGD:724711
Biological Process	GO:0042698	ovulation cycle	Chga	IEP		Rat	PMID:12873792|RGD:6907048
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Chga	IDA		Rat	PMID:22459152|RGD:6906968
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	Chga	IDA		Rat	PMID:22459152|RGD:6906968
Biological Process	GO:2000707	positive regulation of dense core granule biogenesis	Chga	IDA		Mouse	MGI:MGI:5619461|PMID:21436258
Biological Process	GO:1900738	positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	Chga	IDA		Rat	PMID:11257446|RGD:6907050
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Chga	IDA		Rat	PMID:22459152|RGD:6906968
Biological Process	GO:1901899	positive regulation of relaxation of cardiac muscle	Chga	IDA		Rat	PMID:22459152|RGD:6906968
Biological Process	GO:0045907	positive regulation of vasoconstriction	Chga	IDA		Rat	PMID:15544843|RGD:6907046
Biological Process	GO:0033366	protein localization to secretory granule	Chga	IDA		Mouse	PMID:16219686
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	Chga	IDA		Rat	PMID:22459152|RGD:6906968
Biological Process	GO:0002026	regulation of the force of heart contraction	Chga	IDA		Rat	PMID:22459152|RGD:6906968

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern