Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHRM3
  • Mouse genes Chrm3
  • Rat genes Chrm3
  • Zfish genes chrm3a,chrm3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chrm3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042166	acetylcholine binding	Chrm3	IDA		Rat	PMID:1527051|RGD:10047264
Molecular Function	GO:0016907	G protein-coupled acetylcholine receptor activity	Chrm3	IDA		Mouse	PMID:20440069
Molecular Function	GO:0016907	G protein-coupled acetylcholine receptor activity	Chrm3	IMP	MGI:MGI:3770175	Mouse	PMID:16753580
Molecular Function	GO:0016907	G protein-coupled acetylcholine receptor activity	Chrm3	IDA		Rat	PMID:12185001|RGD:724728
Molecular Function	GO:0016907	G protein-coupled acetylcholine receptor activity	Chrm3	IDA		Rat	PMID:1527051|RGD:10047264
Molecular Function	GO:0016907	G protein-coupled acetylcholine receptor activity	chrm3a	IDA		Zfish	PMID:31619590
Molecular Function	GO:0031789	G protein-coupled acetylcholine receptor binding	Chrm3	IDA		Rat	PMID:9316844|RGD:2303391
Molecular Function	GO:0005096	GTPase activator activity	Chrm3	IDA		Mouse	PMID:20440069
Molecular Function	GO:0005096	GTPase activator activity	Chrm3	IMP	MGI:MGI:3770175	Mouse	PMID:16753580
Molecular Function	GO:0005515	protein binding	CHRM3	IPI	UniProtKB:Q8IZF0	Human	PMID:19575010
Molecular Function	GO:0005515	protein binding	CHRM3	IPI	UniProtKB:P08912	Human	PMID:20398705
Molecular Function	GO:0005515	protein binding	CHRM3	IPI	UniProtKB:Q9BVK8	Human	PMID:21056967
Molecular Function	GO:0005515	protein binding	Chrm3	IPI	UniProtKB:Q8BXR5	Mouse	MGI:MGI:5784983|PMID:19575010
Molecular Function	GO:0005515	protein binding	Chrm3	IPI	UniProtKB:P11275	Rat	PMID:20461055|RGD:8554257
Molecular Function	GO:0050997	quaternary ammonium group binding	Chrm3	IDA		Rat	PMID:8075871|RGD:2303390
Cellular Component	GO:0032279	asymmetric synapse	Chrm3	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0043679	axon terminus	Chrm3	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0009925	basal plasma membrane	CHRM3	IDA		Human	PMID:17478539
Cellular Component	GO:0030425	dendrite	Chrm3	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0098978	glutamatergic synapse	Chrm3	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0016020	membrane	Chrm3	IDA		Rat	PMID:8320877|RGD:2303388
Cellular Component	GO:0005886	plasma membrane	CHRM3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CHRM3	IDA		Human	PMID:21056967
Cellular Component	GO:0005886	plasma membrane	Chrm3	IDA		Mouse	PMID:20440069
Cellular Component	GO:0005886	plasma membrane	Chrm3	IMP	MGI:MGI:3770175	Mouse	PMID:16753580
Cellular Component	GO:0005886	plasma membrane	Chrm3	IDA		Rat	PMID:1527051|RGD:10047264
Cellular Component	GO:0098839	postsynaptic density membrane	Chrm3	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0042734	presynaptic membrane	Chrm3	IDA		Rat	PMID:8182478|RGD:2303389
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	CHRM3	IDA		Human	PMID:17478539
Biological Process	GO:0019722	calcium-mediated signaling	CHRM3	IDA		Human	PMID:17478539
Biological Process	GO:0003161	cardiac conduction system development	chrm3a	IMP	ZFIN:ZDB-MRPHLNO-200403-2	Zfish	PMID:31619590
Biological Process	GO:0099565	chemical synaptic transmission, postsynaptic	chrm3a	IDA		Zfish	PMID:31619590|ZFIN:ZDB-PUB-191022-5
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	Chrm3	IDA		Rat	PMID:12185001|RGD:724728
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	Chrm3	IMP		Rat	PMID:15141107|RGD:2303392
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	Chrm3	IDA		Rat	PMID:1527051|RGD:10047264
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	chrm3a	IDA		Zfish	PMID:31619590|ZFIN:ZDB-PUB-191022-5
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	Chrm3	IDA		Mouse	PMID:20440069
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	Chrm3	IDA		Mouse	PMID:20440069
Biological Process	GO:0003063	negative regulation of heart rate by acetylcholine	Chrm3	IMP		Rat	PMID:9316844|RGD:2303391
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	Chrm3	IDA		Mouse	PMID:20440069
Biological Process	GO:0007207	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	Chrm3	IMP	MGI:MGI:3770175	Mouse	PMID:16753580
Biological Process	GO:0032024	positive regulation of insulin secretion	Chrm3	IDA		Mouse	PMID:20440069
Biological Process	GO:0032024	positive regulation of insulin secretion	Chrm3	IMP	MGI:MGI:3770175	Mouse	PMID:16753580
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Chrm3	IDA		Mouse	PMID:12925702
Biological Process	GO:1904695	positive regulation of vascular associated smooth muscle contraction	Chrm3	IMP		Rat	PMID:8428203|RGD:2303387
Biological Process	GO:0045907	positive regulation of vasoconstriction	Chrm3	IMP		Rat	PMID:9316844|RGD:2303391
Biological Process	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	CHRM3	IDA		Human	PMID:17478539
Biological Process	GO:1905144	response to acetylcholine	Chrm3	IMP		Rat	PMID:8075871|RGD:2303390
Biological Process	GO:1905144	response to acetylcholine	Chrm3	IMP		Rat	PMID:9316844|RGD:2303391
Biological Process	GO:0046541	saliva secretion	Chrm3	IMP	MGI:MGI:1888740	Mouse	PMID:10944224
Biological Process	GO:0006939	smooth muscle contraction	Chrm3	IMP	MGI:MGI:1888740	Mouse	PMID:10944224
Biological Process	GO:0006939	smooth muscle contraction	Chrm3	IDA		Mouse	PMID:12925702
Biological Process	GO:0007271	synaptic transmission, cholinergic	Chrm3	IMP	MGI:MGI:1888740	Mouse	PMID:10944224
Biological Process	GO:0007271	synaptic transmission, cholinergic	chrm3a	IDA		Zfish	PMID:31619590|ZFIN:ZDB-PUB-191022-5

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern