Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHRM4
  • Mouse genes Chrm4
  • Rat genes Chrm4
  • Zfish genes chrm4a,chrm4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chrm4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016907	G protein-coupled acetylcholine receptor activity	Chrm4	IDA		Mouse	PMID:7916637
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Chrm4	IDA		Rat	PMID:12048193|RGD:625569
Molecular Function	GO:0005515	protein binding	Chrm4	IPI	RGD:3781	Rat	PMID:12048193|RGD:625569
Molecular Function	GO:0005515	protein binding	Chrm4	IPI	UniProtKB:P11275	Rat	PMID:20461055|RGD:8554257
Cellular Component	GO:0032279	asymmetric synapse	Chrm4	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0043679	axon terminus	Chrm4	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0005737	cytoplasm	Chrm4	IDA		Rat	PMID:15961389|RGD:1598749
Cellular Component	GO:0098978	glutamatergic synapse	Chrm4	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0016020	membrane	Chrm4	IDA		Mouse	PMID:7916637
Cellular Component	GO:0016020	membrane	Chrm4	IDA		Rat	PMID:15961389|RGD:1598749
Cellular Component	GO:0043025	neuronal cell body	Chrm4	IDA		Rat	PMID:12048193|RGD:625569
Cellular Component	GO:0014069	postsynaptic density	Chrm4	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0098839	postsynaptic density membrane	Chrm4	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0042734	presynaptic membrane	Chrm4	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0042383	sarcolemma	Chrm4	IDA		Rat	PMID:15961389|RGD:1598749
Biological Process	GO:0007197	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	Chrm4	IDA		Mouse	PMID:7916637
Biological Process	GO:0010033	response to organic substance	Chrm4	IEP		Rat	PMID:16843632|RGD:2316182

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern