Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHRNA1
  • Mouse genes Chrna1
  • Rat genes Chrna1
  • Zfish genes chrna1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chrna1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042166	acetylcholine binding	Chrna1	IGI	MGI:MGI:87893	Mouse	PMID:8910344
Molecular Function	GO:0042166	acetylcholine binding	chrna1	IMP	ZFIN:ZDB-GENO-120611-8	Zfish	PMID:22674269
Molecular Function	GO:0015464	acetylcholine receptor activity	Chrna1	IDA		Mouse	MGI:MGI:3799559|PMID:8872460
Molecular Function	GO:0015464	acetylcholine receptor activity	chrna1	IDA		Zfish	PMID:22580045
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	CHRNA1	IMP		Human	PMID:9221765
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna1	IGI	MGI:MGI:87894	Mouse	PMID:2383398
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna1	IGI	MGI:MGI:87890	Mouse	PMID:2383398
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna1	IGI	MGI:MGI:87893	Mouse	PMID:2383398
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna1	IGI	MGI:MGI:87895	Mouse	PMID:2383398
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna1	IDA		Rat	PMID:1702709|RGD:68734
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna1	IDA		Rat	PMID:22461452|RGD:8549758
Molecular Function	GO:0005261	monoatomic cation channel activity	chrna1	IDA		Zfish	PMID:15128655
Molecular Function	GO:0005515	protein binding	Chrna1	IPI	PR:Q9CQU3	Mouse	PMID:21187406
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	CHRNA1	IDA		Human	PMID:9221765
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	CHRNA1	IMP		Human	PMID:9221765
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna1	IPI		Mouse	MGI:MGI:6828906|PMID:8334706
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna1	IPI	PR:P02716	Mouse	PMID:8910344
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna1	IDA		Rat	PMID:22461452|RGD:8549758
Cellular Component	GO:0005892	acetylcholine-gated channel complex	chrna1	IDA		Zfish	PMID:22580045
Cellular Component	GO:0005892	acetylcholine-gated channel complex	chrna1	IMP	ZFIN:ZDB-GENO-120611-8	Zfish	PMID:22674269
Cellular Component	GO:0009986	cell surface	CHRNA1	IDA		Human	PMID:12928480
Cellular Component	GO:0009986	cell surface	Chrna1	IDA		Mouse	PMID:21187406
Cellular Component	GO:0016020	membrane	Chrna1	IDA		Mouse	PMID:20053883
Cellular Component	GO:0031594	neuromuscular junction	CHRNA1	IDA		Human	PMID:9221765
Cellular Component	GO:0031594	neuromuscular junction	CHRNA1	IMP		Human	PMID:9221765
Cellular Component	GO:0031594	neuromuscular junction	Chrna1	IDA		Mouse	PMID:20053883
Cellular Component	GO:0031594	neuromuscular junction	Chrna1	IDA		Mouse	PMID:16203963
Cellular Component	GO:0031594	neuromuscular junction	Chrna1	IDA		Mouse	PMID:4781450
Cellular Component	GO:0005886	plasma membrane	CHRNA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Chrna1	IDA		Mouse	PMID:12388596
Cellular Component	GO:0099634	postsynaptic specialization membrane	Chrna1	IDA		Mouse	PMID:4781450
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	Chrna1	IDA		Mouse	MGI:MGI:6850201|PMID:15864502
Biological Process	GO:0003428	chondrocyte intercalation involved in growth plate cartilage morphogenesis	chrna1	IMP	ZFIN:ZDB-GENO-100716-4	Zfish	PMID:22884393
Biological Process	GO:0086009	membrane repolarization	chrna1	IMP	ZFIN:ZDB-GENO-120611-8	Zfish	PMID:23045675
Biological Process	GO:0006812	monoatomic cation transport	Chrna1	IDA		Rat	PMID:22461452|RGD:8549758
Biological Process	GO:0008045	motor neuron axon guidance	chrna1	IMP	ZFIN:ZDB-GENO-040528-1	Zfish	PMID:15128655
Biological Process	GO:0046716	muscle cell cellular homeostasis	CHRNA1	IMP		Human	PMID:8872460
Biological Process	GO:0050881	musculoskeletal movement	CHRNA1	IMP		Human	PMID:18252226
Biological Process	GO:0007528	neuromuscular junction development	CHRNA1	IMP		Human	PMID:9221765
Biological Process	GO:0050905	neuromuscular process	CHRNA1	IMP		Human	PMID:9546329
Biological Process	GO:0007274	neuromuscular synaptic transmission	CHRNA1	IMP		Human	PMID:9221765
Biological Process	GO:0007274	neuromuscular synaptic transmission	chrna1	IDA		Zfish	PMID:15128655
Biological Process	GO:0070050	neuron cellular homeostasis	CHRNA1	IMP		Human	PMID:8872460
Biological Process	GO:0019228	neuronal action potential	CHRNA1	IMP		Human	PMID:8872460
Biological Process	GO:0043113	receptor clustering	chrna1	IMP	ZFIN:ZDB-GENO-980202-64	Zfish	PMID:8293888
Biological Process	GO:0030516	regulation of axon extension	chrna1	IMP	ZFIN:ZDB-GENO-040528-1	Zfish	PMID:15128655
Biological Process	GO:0042391	regulation of membrane potential	CHRNA1	IMP		Human	PMID:9221765
Biological Process	GO:0042391	regulation of membrane potential	CHRNA1	IMP		Human	PMID:8872460
Biological Process	GO:0042391	regulation of membrane potential	Chrna1	IGI	MGI:MGI:87894	Mouse	PMID:2383398
Biological Process	GO:0042391	regulation of membrane potential	Chrna1	IGI	MGI:MGI:87890	Mouse	PMID:2383398
Biological Process	GO:0042391	regulation of membrane potential	Chrna1	IGI	MGI:MGI:87895	Mouse	PMID:2383398
Biological Process	GO:0042391	regulation of membrane potential	Chrna1	IGI	MGI:MGI:87893	Mouse	PMID:2383398
Biological Process	GO:0003009	skeletal muscle contraction	CHRNA1	IMP		Human	PMID:8872460
Biological Process	GO:0003009	skeletal muscle contraction	Chrna1	IDA		Rat	PMID:22461452|RGD:8549758
Biological Process	GO:0048741	skeletal muscle fiber development	chrna1	IMP	ZFIN:ZDB-GENO-980202-64	Zfish	PMID:16249237
Biological Process	GO:0048630	skeletal muscle tissue growth	CHRNA1	IMP		Human	PMID:18252226
Biological Process	GO:0048705	skeletal system morphogenesis	chrna1	IMP		Zfish	PMID:22884393
Biological Process	GO:0007271	synaptic transmission, cholinergic	chrna1	IDA		Zfish	PMID:21844221

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern