Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHRNA10
  • Mouse genes Chrna10
  • Rat genes Chrna10
  • Zfish genes chrna10a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chrna10

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna10	IMP	MGI:MGI:3774038	Mouse	PMID:18077337
Molecular Function	GO:0005515	protein binding	Chrna10	IPI	PR:Q61207	Mouse	PMID:17167097
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Chrna10	IDA		Rat	PMID:11248107|RGD:632443
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Chrna10	IMP		Rat	PMID:11248107|RGD:632443
Cellular Component	GO:0030424	axon	Chrna10	IDA		Rat	PMID:12401316|RGD:724744
Cellular Component	GO:0098981	cholinergic synapse	Chrna10	IDA		Rat	PMID:11248107|RGD:632443
Cellular Component	GO:0098981	cholinergic synapse	Chrna10	IMP		Rat	PMID:11248107|RGD:632443
Cellular Component	GO:0098981	cholinergic synapse	Chrna10	IDA		Rat	PMID:18420419|RGD:2317082
Cellular Component	GO:0043204	perikaryon	Chrna10	IDA		Rat	PMID:12401316|RGD:724744
Cellular Component	GO:0099634	postsynaptic specialization membrane	Chrna10	IDA		Rat	PMID:18420419|RGD:2317082
Cellular Component	GO:0045202	synapse	Chrna10	IMP	MGI:MGI:3774038	Mouse	MGI:MGI:3771935|PMID:18077337
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	Chrna10	IMP	MGI:MGI:3774038	Mouse	PMID:18077337
Biological Process	GO:0042472	inner ear morphogenesis	Chrna10	IMP	MGI:MGI:3774038	Mouse	PMID:18077337
Biological Process	GO:0051899	membrane depolarization	Chrna10	IMP		Mouse	MGI:MGI:3771935|PMID:18077337
Biological Process	GO:0051899	membrane depolarization	Chrna10	IDA		Rat	PMID:25193338|RGD:150521631
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Chrna10	IMP		Rat	PMID:20505147|RGD:8549538
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	CHRNA10	IGI	UniProtKB:Q9UGM1	Human	PMID:18420419
Biological Process	GO:0010996	response to auditory stimulus	Chrna10	IMP		Mouse	MGI:MGI:3831579|PMID:19166271
Biological Process	GO:0010996	response to auditory stimulus	Chrna10	IDA		Rat	PMID:11248107|RGD:632443
Biological Process	GO:0007271	synaptic transmission, cholinergic	Chrna10	IMP	MGI:MGI:3774038	Mouse	PMID:18077337

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern