Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Chrna3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CHRNA3
- Mouse genes Chrna3
- Rat genes Chrna3
- Zfish genes chrna3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chrna3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042166	acetylcholine binding	Chrna3	IDA		Rat	PMID:11297818\|RGD:1643016
Molecular Function	GO:0015464	acetylcholine receptor activity	CHRNA3	IDA		Human	PMID:8906617
Molecular Function	GO:0015464	acetylcholine receptor activity	Chrna3	IDA		Rat	PMID:2444984\|RGD:69807
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	CHRNA3	IDA		Human	PMID:8906617
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:11923417
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna3	IMP		Rat	PMID:11297818\|RGD:1643016
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna3	IGI	UniProtKB:P12390	Rat	PMID:21540349\|RGD:12790638
Molecular Function	GO:1901363	heterocyclic compound binding	Chrna3	IDA		Rat	PMID:15016836\|RGD:2303194
Molecular Function	GO:1901363	heterocyclic compound binding	Chrna3	IPI	CHEBI:4803\|CHEBI:4055\|CHEBI:18723\|CHEBI:34705\|CHEBI:3385\|CHEBI:6706\|CHEBI:43931\|CHEBI:15355\|CHEBI:34705\|CHEBI:4290	Rat	PMID:15016836\|RGD:2303194
Molecular Function	GO:1901363	heterocyclic compound binding	Chrna3	IPI	CHEBI:34705\|CHEBI:4803\|CHEBI:18723\|CHEBI:4055	Rat	PMID:16129735\|RGD:2303195
Molecular Function	GO:0005515	protein binding	CHRNA3	IPI	UniProtKB:Q86Y78	Human	PMID:27344019
Molecular Function	GO:0005515	protein binding	Chrna3	IPI	PR:Q99KJ0	Mouse	PMID:19474315
Molecular Function	GO:0044877	protein-containing complex binding	Chrna3	IDA		Rat	PMID:20796176\|RGD:8549534
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Chrna3	IMP		Mouse	PMID:16162937
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Chrna3	IDA		Mouse	PMID:16162937
Cellular Component	GO:0005892	acetylcholine-gated channel complex	CHRNA3	IDA		Human	PMID:8906617
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna3	IPI	UniProtKB:Q3KP94	Mouse	PMID:17434683
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna3	IDA		Rat	PMID:20796176\|RGD:8549534
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna3	IGI	UniProtKB:P12390	Rat	PMID:21540349\|RGD:12790638
Cellular Component	GO:0098981	cholinergic synapse	Chrna3	IDA		Mouse	PMID:16162937
Cellular Component	GO:0098981	cholinergic synapse	Chrna3	IMP		Mouse	PMID:16162937
Cellular Component	GO:0098981	cholinergic synapse	Chrna3	IDA		Mouse	PMID:12079404
Cellular Component	GO:0098981	cholinergic synapse	Chrna3	IDA		Rat	PMID:3380297\|RGD:13702334
Cellular Component	GO:0030425	dendrite	Chrna3	IDA		Rat	PMID:11297818\|RGD:1643016
Cellular Component	GO:0098691	dopaminergic synapse	Chrna3	EXP		Rat	PMID:12065717\|RGD:13702272
Cellular Component	GO:0098691	dopaminergic synapse	Chrna3	IDA		Rat	PMID:12065717\|RGD:13702272
Cellular Component	GO:0016020	membrane	Chrna3	IDA		Rat	PMID:16129735\|RGD:2303195
Cellular Component	GO:0043025	neuronal cell body	Chrna3	IDA		Rat	PMID:11297818\|RGD:1643016
Cellular Component	GO:0016607	nuclear speck	CHRNA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CHRNA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0044853	plasma membrane raft	Chrna3	IGI	UniProtKB:P12390	Rat	PMID:21540349\|RGD:12790638
Cellular Component	GO:0014069	postsynaptic density	Chrna3	IDA		Rat	PMID:14989600\|RGD:1599611
Cellular Component	GO:0099634	postsynaptic specialization membrane	Chrna3	IDA		Mouse	PMID:12079404
Cellular Component	GO:0099634	postsynaptic specialization membrane	Chrna3	IDA		Rat	PMID:3380297\|RGD:13702334
Cellular Component	GO:0032991	protein-containing complex	Chrna3	IDA		Rat	PMID:16129735\|RGD:2303195
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	Chrna3	IGI	UniProtKB:P12390	Rat	PMID:21540349\|RGD:12790638
Biological Process	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:16162937
Biological Process	GO:0035095	behavioral response to nicotine	CHRNA3	IMP		Human	PMID:18227835
Biological Process	GO:0035095	behavioral response to nicotine	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:15275829
Biological Process	GO:0060079	excitatory postsynaptic potential	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:16162937
Biological Process	GO:0007507	heart development	Chrna3	IEP		Rat	PMID:15549397\|RGD:1599606
Biological Process	GO:0007626	locomotory behavior	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:15275829
Biological Process	GO:0051899	membrane depolarization	Chrna3	IDA		Rat	PMID:15247319\|RGD:150521650
Biological Process	GO:0007399	nervous system development	CHRNA3	IMP		Human	PMID:11450844
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Chrna3	EXP		Rat	PMID:12065717\|RGD:13702272
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Chrna3	IDA		Rat	PMID:12065717\|RGD:13702272
Biological Process	GO:0014056	regulation of acetylcholine secretion, neurotransmission	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:16162937
Biological Process	GO:0048814	regulation of dendrite morphogenesis	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:11027228
Biological Process	GO:0042391	regulation of membrane potential	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:10318955
Biological Process	GO:0006937	regulation of muscle contraction	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:10318955
Biological Process	GO:0006940	regulation of smooth muscle contraction	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:10318955
Biological Process	GO:0006940	regulation of smooth muscle contraction	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:10771006
Biological Process	GO:1905144	response to acetylcholine	Chrna3	IGI	UniProtKB:P12390	Rat	PMID:21540349\|RGD:12790638
Biological Process	GO:0034465	response to carbon monoxide	Chrna3	IEP		Rat	PMID:24704181\|RGD:151347543
Biological Process	GO:0010035	response to inorganic substance	Chrna3	IEP		Rat	PMID:15212813\|RGD:1599609
Biological Process	GO:0035094	response to nicotine	Chrna3	IEP		Rat	PMID:17105949\|RGD:1599604
Biological Process	GO:0009410	response to xenobiotic stimulus	Chrna3	IDA		Rat	PMID:15896488\|RGD:1599603
Biological Process	GO:0007165	signal transduction	CHRNA3	IDA		Human	PMID:8906617
Biological Process	GO:0060084	synaptic transmission involved in micturition	CHRNA3	IMP		Human	PMID:11450844
Biological Process	GO:0060084	synaptic transmission involved in micturition	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:10771006
Biological Process	GO:0007271	synaptic transmission, cholinergic	Chrna3	IMP	MGI:MGI:2155602	Mouse	PMID:16162937

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.