Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHRNA5
  • Mouse genes Chrna5
  • Rat genes Chrna5
  • Zfish genes chrna5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chrna5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042166	acetylcholine binding	Chrna5	IDA		Rat	PMID:11297818|RGD:1643016
Molecular Function	GO:0015464	acetylcholine receptor activity	CHRNA5	IDA		Human	PMID:1542648
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna5	IMP		Rat	PMID:11297818|RGD:1643016
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna5	IMP		Rat	PMID:12814364|RGD:1298760
Molecular Function	GO:0005515	protein binding	CHRNA5	IPI	UniProtKB:Q86Y78	Human	PMID:27344019
Molecular Function	GO:0005515	protein binding	CHRNA5	IPI	UniProtKB:P17787	Human	PMID:8663494
Molecular Function	GO:0005515	protein binding	Chrna5	IPI	UniProtKB:P09483	Rat	PMID:20566638|RGD:10047290
Molecular Function	GO:0044877	protein-containing complex binding	Chrna5	IDA		Rat	PMID:20796176|RGD:8549534
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna5	IPI	PR:O70174	Mouse	PMID:17434683
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna5	IPI	PR:Q8R4G9	Mouse	PMID:17434683
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna5	IDA		Rat	PMID:20796176|RGD:8549534
Cellular Component	GO:0030425	dendrite	Chrna5	IDA		Rat	PMID:11297818|RGD:1643016
Cellular Component	GO:0098691	dopaminergic synapse	Chrna5	IDA		Mouse	PMID:19693710
Cellular Component	GO:0098691	dopaminergic synapse	Chrna5	IMP		Mouse	PMID:19693710
Cellular Component	GO:0043025	neuronal cell body	Chrna5	IDA		Rat	PMID:11297818|RGD:1643016
Cellular Component	GO:0005886	plasma membrane	Chrna5	IDA		Rat	PMID:12748066|RGD:1600980
Cellular Component	GO:0098793	presynapse	Chrna5	IDA		Mouse	MGI:MGI:6191866|PMID:19693710
Biological Process	GO:0035095	behavioral response to nicotine	CHRNA5	IMP		Human	PMID:18227835
Biological Process	GO:0035095	behavioral response to nicotine	Chrna5	IMP		Rat	PMID:21278726|RGD:150527840
Biological Process	GO:0035095	behavioral response to nicotine	Chrna5	IMP		Rat	PMID:30293722|RGD:14694852
Biological Process	GO:0071316	cellular response to nicotine	Chrna5	IMP		Rat	PMID:30293722|RGD:14694852
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Chrna5	IMP		Rat	PMID:15652389|RGD:150530460
Biological Process	GO:0021766	hippocampus development	Chrna5	IEP		Rat	PMID:15558717|RGD:150530459
Biological Process	GO:0051899	membrane depolarization	Chrna5	IDA		Mouse	MGI:MGI:6810694|PMID:24144909
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Chrna5	IMP		Mouse	PMID:19693710
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Chrna5	IDA		Mouse	PMID:19693710
Biological Process	GO:0098908	regulation of neuronal action potential	Chrna5	IMP		Rat	PMID:30293722|RGD:14694852
Biological Process	GO:0035094	response to nicotine	Chrna5	IMP		Mouse	PMID:9495872

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern