Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHRNB4
  • Mouse genes Chrnb4
  • Rat genes Chrnb4
  • Zfish genes chrnb4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chrnb4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042166	acetylcholine binding	Chrnb4	IDA		Rat	PMID:9030613|RGD:2303190
Molecular Function	GO:0015464	acetylcholine receptor activity	CHRNB4	IDA		Human	PMID:8906617
Molecular Function	GO:0015464	acetylcholine receptor activity	chrnb4	IDA		Zfish	PMID:22580045
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	CHRNB4	IDA		Human	PMID:18387948
Molecular Function	GO:1901363	heterocyclic compound binding	Chrnb4	IPI	CHEBI:4803	Rat	PMID:16129735|RGD:2303195
Molecular Function	GO:1901363	heterocyclic compound binding	Chrnb4	IDA		Rat	PMID:15016836|RGD:2303194
Molecular Function	GO:1901363	heterocyclic compound binding	Chrnb4	IPI	CHEBI:4803|CHEBI:4055|CHEBI:18723|CHEBI:34705	Rat	PMID:15016836|RGD:2303194
Molecular Function	GO:0005515	protein binding	CHRNB4	IPI	UniProtKB:Q86Y78	Human	PMID:27344019
Molecular Function	GO:0005515	protein binding	CHRNB4	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Chrnb4	IPI	UniProtKB:P09483	Rat	PMID:20566638|RGD:10047290
Molecular Function	GO:0044877	protein-containing complex binding	Chrnb4	IDA		Rat	PMID:20796176|RGD:8549534
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Chrnb4	IMP		Mouse	PMID:23811311
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Chrnb4	IDA		Mouse	PMID:23811311
Cellular Component	GO:0005892	acetylcholine-gated channel complex	CHRNB4	IDA		Human	PMID:8906617
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrnb4	IDA		Rat	PMID:20796176|RGD:8549534
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrnb4	IDA		Rat	PMID:9030613|RGD:2303190
Cellular Component	GO:0005892	acetylcholine-gated channel complex	chrnb4	IDA		Zfish	PMID:22580045
Cellular Component	GO:0098981	cholinergic synapse	Chrnb4	IMP		Mouse	PMID:23811311
Cellular Component	GO:0098981	cholinergic synapse	Chrnb4	IDA		Mouse	PMID:23811311
Cellular Component	GO:0016020	membrane	Chrnb4	IDA		Rat	PMID:16129735|RGD:2303195
Cellular Component	GO:0043005	neuron projection	Chrnb4	IDA		Rat	PMID:9030613|RGD:2303190
Cellular Component	GO:0005886	plasma membrane	Chrnb4	IDA		Rat	PMID:19474315|RGD:8554250
Cellular Component	GO:0032991	protein-containing complex	Chrnb4	IDA		Rat	PMID:16129735|RGD:2303195
Biological Process	GO:0035095	behavioral response to nicotine	Chrnb4	IMP	MGI:MGI:2158716	Mouse	PMID:15537871
Biological Process	GO:0035095	behavioral response to nicotine	Chrnb4	IMP	MGI:MGI:2158716	Mouse	PMID:15275829
Biological Process	GO:0007626	locomotory behavior	Chrnb4	IMP	MGI:MGI:2158716	Mouse	PMID:15275829
Biological Process	GO:0051899	membrane depolarization	Chrnb4	IDA		Rat	PMID:15247319|RGD:150521650
Biological Process	GO:0019228	neuronal action potential	Chrnb4	IGI	MGI:MGI:87891	Mouse	PMID:10531434
Biological Process	GO:0051971	positive regulation of transmission of nerve impulse	Chrnb4	IMP		Mouse	MGI:MGI:3610896|PMID:12606764
Biological Process	GO:0042391	regulation of membrane potential	Chrnb4	IGI	MGI:MGI:87891	Mouse	PMID:10531434
Biological Process	GO:0006940	regulation of smooth muscle contraction	Chrnb4	IMP	MGI:MGI:2158716	Mouse	PMID:10771006
Biological Process	GO:0035094	response to nicotine	Chrnb4	IGI	MGI:MGI:87891	Mouse	PMID:10531434
Biological Process	GO:0007165	signal transduction	CHRNB4	IDA		Human	PMID:8906617
Biological Process	GO:0006939	smooth muscle contraction	Chrnb4	IGI	MGI:MGI:87891	Mouse	PMID:10531434
Biological Process	GO:0060084	synaptic transmission involved in micturition	CHRNB4	IMP		Human	PMID:11450844
Biological Process	GO:0060084	synaptic transmission involved in micturition	Chrnb4	IGI	MGI:MGI:87891	Mouse	PMID:10531434
Biological Process	GO:0060084	synaptic transmission involved in micturition	Chrnb4	IMP	MGI:MGI:2158716	Mouse	PMID:10771006

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern