Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHUK
  • Mouse genes Chuk
  • Rat genes Chuk
  • Zfish genes chuk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chuk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008384	IkappaB kinase activity	Chuk	IDA		Rat	PMID:14572607|RGD:2298665
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q04206	Human	PMID:10521409
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P25963	Human	PMID:10733566
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P19838	Human	PMID:11297557
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:11971985
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P19838	Human	PMID:12482991
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:12486103
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P25963	Human	PMID:12486103
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:12486103
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P25963	Human	PMID:12730857
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P07900	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P25963	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q13451	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q16543	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q99558	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:14743216
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P32121	Human	PMID:15125834
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q96EY1-1	Human	PMID:15601829
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q96EY1-2	Human	PMID:15601829
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:15749833
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:16126728
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:16129692
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:16286467
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P25963	Human	PMID:16286467
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q99558	Human	PMID:16286467
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:16319058
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:16319058
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q99558	Human	PMID:16498412
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:16938294
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:17363973
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:17568778
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P24772	Human	PMID:18266467
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:18266467
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q15796	Human	PMID:18268325
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P63167	Human	PMID:18579519
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P25963	Human	PMID:18922877
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q77M19	Human	PMID:18922877
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q92985	Human	PMID:18922877
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:19666608
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P07900	Human	PMID:19875381
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:20368414
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:20434986
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q86WI3	Human	PMID:20434986
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:20434986
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P71451	Human	PMID:20855622
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q6P9F5	Human	PMID:21474709
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P01106	Human	PMID:21575199
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P25963	Human	PMID:21765415
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q86VP1	Human	PMID:21765415
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q04206	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q16543	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P03129	Human	PMID:22776252
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q07857	Human	PMID:22776252
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q6TY28	Human	PMID:22776252
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q6TY35	Human	PMID:22776252
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q80901	Human	PMID:22776252
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q8B5B5	Human	PMID:22776252
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P24772	Human	PMID:22810585
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q14587-2	Human	PMID:23091055
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P25963	Human	PMID:23602409
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P46527	Human	PMID:23602409
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q16543	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:24618592
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q13451	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q16543	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q99558	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:25355947
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P19838	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q13325	Human	PMID:26334375
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q5TCX8	Human	PMID:26859459
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q15048	Human	PMID:27426725
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P25963	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q99558	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O00571	Human	PMID:30341167
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q99558	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q99558	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q16543	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q99558	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920,UniProtKB:Q9Y6K9	Human	PMID:32935379
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q04206	Human	PMID:8246997
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:P25963	Human	PMID:9520446
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q99558	Human	PMID:9520446
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:O14920	Human	PMID:9751060
Molecular Function	GO:0005515	protein binding	CHUK	IPI	UniProtKB:Q9Y6K9	Human	PMID:9751060
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:Q77M19	Mouse	MGI:MGI:5493212|PMID:18922877
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:B7ZNY0|UniProtKB:P02535|UniProtKB:Q8BP22	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:O88351	Mouse	MGI:MGI:3619210|PMID:16498412
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:Q91VL8	Mouse	MGI:MGI:4821187|PMID:20622870
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:P25963|UniProtKB:Q99558	Mouse	MGI:MGI:3773773|PMID:10733566
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:O88522	Mouse	MGI:MGI:4946301|PMID:21455181
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:P70434	Mouse	MGI:MGI:3621577|PMID:16612387
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:O88522	Mouse	MGI:MGI:5009780|PMID:20818435
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:P04862|UniProtKB:P06164|UniProtKB:P0C1C7|UniProtKB:P35977	Mouse	MGI:MGI:5538412|PMID:24269682
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:O88522	Mouse	MGI:MGI:6092615|PMID:18216269
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:O88522	Mouse	MGI:MGI:5315695|PMID:18266467
Molecular Function	GO:0005515	protein binding	Chuk	IPI	UniProtKB:O88351|UniProtKB:O88522	Mouse	MGI:MGI:4454346|PMID:20434986
Molecular Function	GO:0005515	protein binding	Chuk	IPI	PR:O88351	Mouse	PMID:17041603
Molecular Function	GO:0005515	protein binding	Chuk	IPI	PR:Q8BMS9	Mouse	PMID:22227519
Molecular Function	GO:0005515	protein binding	chuk	IPI	UniProtKB:Q58EN3	Zfish	PMID:16051172
Molecular Function	GO:0046982	protein heterodimerization activity	CHUK	IDA		Human	PMID:23091055
Molecular Function	GO:0042803	protein homodimerization activity	CHUK	IDA		Human	PMID:23091055
Molecular Function	GO:0004672	protein kinase activity	CHUK	IDA		Human	PMID:20434986
Molecular Function	GO:0004672	protein kinase activity	Chuk	IDA		Mouse	PMID:15684432
Molecular Function	GO:0044877	protein-containing complex binding	Chuk	IPI	RGD:735223	Rat	PMID:17419723|RGD:2298661
Molecular Function	GO:0097110	scaffold protein binding	CHUK	IDA		Human	PMID:23776175
Molecular Function	GO:1990459	transferrin receptor binding	CHUK	IPI	UniProtKB:P02786	Human	PMID:23016877
Cellular Component	GO:0035631	CD40 receptor complex	Chuk	IDA		Mouse	MGI:MGI:4462284|PMID:20614026
Cellular Component	GO:0005737	cytoplasm	CHUK	IDA		Human	PMID:30341167
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	Chuk	IDA		Mouse	MGI:MGI:4462284|PMID:20614026
Cellular Component	GO:0005829	cytosol	CHUK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Chuk	IDA		Rat	PMID:17419723|RGD:2298661
Cellular Component	GO:0008385	IkappaB kinase complex	Chuk	IDA		Rat	PMID:17419723|RGD:2298661
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Chuk	IDA		Rat	PMID:12361703|RGD:2298666
Cellular Component	GO:0005654	nucleoplasm	CHUK	IDA		Human	GO_REF:0000052
Biological Process	GO:0071276	cellular response to cadmium ion	CHUK	IMP		Human	PMID:26514923
Biological Process	GO:0034614	cellular response to reactive oxygen species	CHUK	IMP		Human	PMID:26514923
Biological Process	GO:0071356	cellular response to tumor necrosis factor	CHUK	IDA		Human	PMID:23091055
Biological Process	GO:0098586	cellular response to virus	CHUK	IMP		Human	PMID:24784232
Biological Process	GO:0098586	cellular response to virus	Chuk	IMP		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:0007417	central nervous system development	chuk	IMP	ZFIN:ZDB-MRPHLNO-050818-1	Zfish	PMID:16051172
Biological Process	GO:0051607	defense response to virus	Chuk	IMP		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	chuk	IMP	ZFIN:ZDB-GENO-101027-6	Zfish	PMID:20692251
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	CHUK	IMP		Human	PMID:26514923
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	CHUK	IDA		Human	PMID:9244310
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Chuk	IGI	MGI:MGI:1100089	Mouse	PMID:11747812
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Chuk	IMP	MGI:MGI:3045616	Mouse	PMID:11747812
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	chuk	IDA		Zfish	PMID:16051172
Biological Process	GO:0007595	lactation	Chuk	IMP	MGI:MGI:3045616	Mouse	PMID:11747812
Biological Process	GO:0007595	lactation	Chuk	IGI	MGI:MGI:88313	Mouse	PMID:11747812
Biological Process	GO:0060749	mammary gland alveolus development	Chuk	IMP	MGI:MGI:3045616	Mouse	PMID:11747812
Biological Process	GO:0060749	mammary gland alveolus development	Chuk	IGI	MGI:MGI:88313	Mouse	PMID:11747812
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	Chuk	IMP	MGI:MGI:3045616	Mouse	PMID:11747812
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	Chuk	IGI	MGI:MGI:88313	Mouse	PMID:11747812
Biological Process	GO:0002011	morphogenesis of an epithelial sheet	Chuk	IMP	MGI:MGI:3045616	Mouse	PMID:14960276
Biological Process	GO:0043066	negative regulation of apoptotic process	chuk	IMP	ZFIN:ZDB-MRPHLNO-050818-1	Zfish	PMID:16051172
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	chuk	IDA		Zfish	PMID:16051172
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	CHUK	IMP		Human	PMID:11536016
Biological Process	GO:0038061	NIK/NF-kappaB signaling	CHUK	IMP		Human	PMID:26514923
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Chuk	IMP	MGI:MGI:3039784	Mouse	PMID:14960276
Biological Process	GO:0030316	osteoclast differentiation	Chuk	IGI	MGI:MGI:1100089	Mouse	PMID:15485831
Biological Process	GO:0030316	osteoclast differentiation	Chuk	IMP	MGI:MGI:1857735	Mouse	PMID:15485831
Biological Process	GO:0030316	osteoclast differentiation	Chuk	IGI	MGI:MGI:104798	Mouse	PMID:15485831
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CHUK	IMP		Human	PMID:26514923
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	CHUK	IMP		Human	PMID:23487264
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Chuk	IGI	MGI:MGI:1100089	Mouse	PMID:11747812
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Chuk	IMP	MGI:MGI:3045616	Mouse	PMID:11747812
Biological Process	GO:0032727	positive regulation of interferon-alpha production	CHUK	IMP		Human	PMID:24784232
Biological Process	GO:0032727	positive regulation of interferon-alpha production	Chuk	IMP		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	CHUK	IDA		Human	PMID:23091055
Biological Process	GO:0006468	protein phosphorylation	CHUK	IDA		Human	PMID:20434986
Biological Process	GO:0006468	protein phosphorylation	Chuk	IDA		Mouse	MGI:MGI:6305600|PMID:30988283
Biological Process	GO:0010034	response to acetate	Chuk	IEP		Rat	PMID:17543437|RGD:2298659
Biological Process	GO:0043200	response to amino acid	Chuk	IEP		Rat	PMID:17543437|RGD:2298659
Biological Process	GO:0061847	response to cholecystokinin	Chuk	IDA		Rat	PMID:12592100|RGD:13801014
Biological Process	GO:0033194	response to hydroperoxide	Chuk	IEP		Rat	PMID:16028365|RGD:2298663
Biological Process	GO:0032496	response to lipopolysaccharide	Chuk	IDA		Rat	PMID:14572607|RGD:2298665
Biological Process	GO:0035994	response to muscle stretch	Chuk	IMP		Mouse	PMID:20442316
Biological Process	GO:0010033	response to organic substance	Chuk	IDA		Rat	PMID:14572607|RGD:2298665
Biological Process	GO:0009636	response to toxic substance	Chuk	IEP		Rat	PMID:12361703|RGD:2298666
Biological Process	GO:0009410	response to xenobiotic stimulus	Chuk	IEP		Rat	PMID:16331110|RGD:2298662
Biological Process	GO:0007266	Rho protein signal transduction	Chuk	IMP		Rat	PMID:14572607|RGD:2298665
Biological Process	GO:0003009	skeletal muscle contraction	Chuk	IEP		Rat	PMID:15888549|RGD:2298664
Biological Process	GO:0001757	somite specification	chuk	IMP	ZFIN:ZDB-MRPHLNO-050818-1	Zfish	PMID:16051172
Biological Process	GO:0051146	striated muscle cell differentiation	Chuk	IMP		Rat	PMID:11279241|RGD:2298667

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern