Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cited2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CITED2
- Mouse genes Cited2
- Rat genes Cited2
- Zfish genes cited2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cited2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Cited2	IDA		Mouse	MGI:MGI:3054669\|PMID:15475956
Molecular Function	GO:0003682	chromatin binding	Cited2	IDA		Mouse	PMID:16619037
Molecular Function	GO:0003682	chromatin binding	Cited2	IDA		Mouse	PMID:18653562
Molecular Function	GO:0035035	histone acetyltransferase binding	CITED2	IDA		Human	PMID:22735262
Molecular Function	GO:0050693	LBD domain binding	CITED2	IPI	UniProtKB:P37230	Human	PMID:15051727
Molecular Function	GO:0140677	molecular function activator activity	CITED2	EXP		Human	PMID:14594809
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:P05549	Human	PMID:11694877
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:Q92481	Human	PMID:11694877
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:Q92754	Human	PMID:11694877
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:Q09472	Human	PMID:12586840
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:Q92754	Human	PMID:12586840
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:Q9UBK9	Human	PMID:12762840
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:P37230	Human	PMID:15051727
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:P41235	Human	PMID:17932483
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:P60891	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:Q09472	Human	PMID:9887100
Molecular Function	GO:0005515	protein binding	CITED2	IPI	UniProtKB:Q92793	Human	PMID:9887100
Molecular Function	GO:0005515	protein binding	Cited2	IPI	UniProtKB:P22561-1\|UniProtKB:P22561-3	Mouse	MGI:MGI:3790398\|PMID:17537799
Molecular Function	GO:0005515	protein binding	Cited2	IPI	UniProtKB:B2RWS6\|UniProtKB:P29037\|UniProtKB:Q9Z0S2	Mouse	MGI:MGI:5009206\|PMID:10593900
Molecular Function	GO:0005515	protein binding	Cited2	IPI	UniProtKB:O70436\|UniProtKB:P84025	Mouse	MGI:MGI:3690196\|PMID:16619037
Molecular Function	GO:0019904	protein domain specific binding	CITED2	IPI	UniProtKB:P45481	Human	PMID:14594809
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Cited2	IPI	UniProtKB:P49698	Mouse	MGI:MGI:3813432\|PMID:17932483
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Cited2	IPI	PR:Q61313	Mouse	PMID:11694877
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Cited2	IPI	PR:P34056	Mouse	PMID:11694877
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Cited2	IPI	PR:Q61312	Mouse	PMID:11694877
Molecular Function	GO:0046332	SMAD binding	Cited2	IPI	PR:Q8BUN5	Mouse	PMID:16619037
Molecular Function	GO:0046332	SMAD binding	Cited2	IPI	PR:Q62432	Mouse	PMID:16619037
Molecular Function	GO:0003713	transcription coactivator activity	CITED2	IDA		Human	PMID:11581164
Molecular Function	GO:0003713	transcription coactivator activity	CITED2	IDA		Human	PMID:11694877
Molecular Function	GO:0003713	transcription coactivator activity	CITED2	IDA		Human	PMID:15051727
Molecular Function	GO:0003713	transcription coactivator activity	CITED2	IDA		Human	PMID:22735262
Molecular Function	GO:0003713	transcription coactivator activity	Cited2	IDA		Mouse	MGI:MGI:3790398\|PMID:17537799
Molecular Function	GO:0003713	transcription coactivator activity	Cited2	IDA		Mouse	MGI:MGI:3813432\|PMID:17932483
Molecular Function	GO:0003713	transcription coactivator activity	Cited2	IDA		Mouse	MGI:MGI:5009206\|PMID:10593900
Molecular Function	GO:0003713	transcription coactivator activity	Cited2	IDA		Mouse	PMID:11694877
Molecular Function	GO:0003713	transcription coactivator activity	Cited2	IDA		Mouse	PMID:16619037
Molecular Function	GO:0003714	transcription corepressor activity	CITED2	IMP		Human	PMID:17906695
Molecular Function	GO:0003714	transcription corepressor activity	CITED2	IDA		Human	PMID:22735262
Molecular Function	GO:0003714	transcription corepressor activity	CITED2	IDA		Human	PMID:9887100
Cellular Component	GO:0000785	chromatin	Cited2	IDA		Mouse	MGI:MGI:3813432\|PMID:17932483
Cellular Component	GO:0005829	cytosol	CITED2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CITED2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CITED2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CITED2	IDA		Human	PMID:22735262
Cellular Component	GO:0005634	nucleus	CITED2	IDA		Human	PMID:9434189
Cellular Component	GO:0005634	nucleus	CITED2	IDA		Human	PMID:9887100
Cellular Component	GO:0005634	nucleus	Cited2	IDA		Mouse	MGI:MGI:3813432\|PMID:17932483
Cellular Component	GO:0005634	nucleus	Cited2	IDA		Mouse	MGI:MGI:1312962\|PMID:9811838
Cellular Component	GO:0005634	nucleus	Cited2	IDA		Mouse	PMID:18653562
Cellular Component	GO:0032991	protein-containing complex	CITED2	IMP		Human	PMID:14594809
Biological Process	GO:0035802	adrenal cortex formation	Cited2	IMP		Mouse	MGI:MGI:3790398\|PMID:17537799
Biological Process	GO:0030325	adrenal gland development	Cited2	IMP	MGI:MGI:2179740	Mouse	PMID:11694877
Biological Process	GO:0030325	adrenal gland development	Cited2	IMP	MGI:MGI:2179740	Mouse	PMID:15615595
Biological Process	GO:0001568	blood vessel development	Cited2	IMP	MGI:MGI:2179740	Mouse	PMID:15615595
Biological Process	GO:0060349	bone morphogenesis	Cited2	IMP	MGI:MGI:2179740	Mouse	PMID:20549734
Biological Process	GO:0061308	cardiac neural crest cell development involved in heart development	Cited2	IMP	MGI:MGI:2179740	Mouse	PMID:11694877
Biological Process	GO:0060411	cardiac septum morphogenesis	Cited2	IMP	MGI:MGI:2179740	Mouse	PMID:11694877
Biological Process	GO:0008283	cell population proliferation	CITED2	IDA		Human	PMID:15051727
Biological Process	GO:0071363	cellular response to growth factor stimulus	Cited2	IEP		Rat	PMID:19013137\|RGD:5147853
Biological Process	GO:0090398	cellular senescence	Cited2	IEP		Rat	PMID:20569237\|RGD:5147849
Biological Process	GO:0007417	central nervous system development	Cited2	IMP	MGI:MGI:2176158	Mouse	PMID:11823447
Biological Process	GO:0021602	cranial nerve morphogenesis	Cited2	IMP	MGI:MGI:2179740	Mouse	PMID:11694877
Biological Process	GO:0046697	decidualization	Cited2	IMP	MGI:MGI:2176158	Mouse	PMID:16579983
Biological Process	GO:0061371	determination of heart left/right asymmetry	Cited2	IMP	MGI:MGI:2176158	Mouse	PMID:15750185
Biological Process	GO:0007368	determination of left/right symmetry	Cited2	IMP		Mouse	MGI:MGI:3574743\|PMID:15750185
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	Cited2	IGI	MGI:MGI:97490	Mouse	PMID:18653562
Biological Process	GO:0060971	embryonic heart tube left/right pattern formation	Cited2	IMP		Mouse	MGI:MGI:3054669\|PMID:15475956
Biological Process	GO:0001892	embryonic placenta development	Cited2	IMP	MGI:MGI:2176158	Mouse	PMID:16579983
Biological Process	GO:0060136	embryonic process involved in female pregnancy	Cited2	IMP	MGI:MGI:2176158	Mouse	PMID:16579983
Biological Process	GO:0003197	endocardial cushion development	Cited2	IMP	MGI:MGI:2176158	Mouse	PMID:15750185
Biological Process	GO:0048821	erythrocyte development	Cited2	IMP	MGI:MGI:2385355	Mouse	PMID:17644732
Biological Process	GO:0030851	granulocyte differentiation	Cited2	IMP	MGI:MGI:2385355	Mouse	PMID:17644732
Biological Process	GO:0007507	heart development	CITED2	IMP		Human	PMID:16287139
Biological Process	GO:0007507	heart development	Cited2	IMP		Mouse	MGI:MGI:3574743\|PMID:15750185
Biological Process	GO:0001947	heart looping	Cited2	IMP	MGI:MGI:2176158	Mouse	PMID:15750185
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Cited2	IMP	MGI:MGI:2385355	Mouse	PMID:17644732
Biological Process	GO:0001701	in utero embryonic development	Cited2	IMP	MGI:MGI:2176158	Mouse	PMID:16579983
Biological Process	GO:0070986	left/right axis specification	Cited2	IMP		Mouse	MGI:MGI:3054669\|PMID:15475956
Biological Process	GO:0002089	lens morphogenesis in camera-type eye	Cited2	IMP	MGI:MGI:3045749,MGI:MGI:3696062	Mouse	PMID:18653562
Biological Process	GO:0002521	leukocyte differentiation	Cited2	IMP	MGI:MGI:2385355	Mouse	PMID:17644732
Biological Process	GO:0001889	liver development	Cited2	IMP		Mouse	MGI:MGI:3813432\|PMID:17932483
Biological Process	GO:0001889	liver development	Cited2	IMP	MGI:MGI:2385355	Mouse	PMID:17644732
Biological Process	GO:0008584	male gonad development	Cited2	IGI	MGI:MGI:1346833	Mouse	PMID:19457926
Biological Process	GO:0008584	male gonad development	Cited2	IGI	MGI:MGI:98968	Mouse	PMID:19457926
Biological Process	GO:0043066	negative regulation of apoptotic process	Cited2	IMP		Mouse	MGI:MGI:3813432\|PMID:17932483
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	Cited2	IMP		Rat	PMID:26240138\|RGD:13210532
Biological Process	GO:0030336	negative regulation of cell migration	CITED2	IMP		Human	PMID:18054336
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	CITED2	IDA		Human	PMID:15051727
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	CITED2	IMP		Human	PMID:9887100
Biological Process	GO:0010629	negative regulation of gene expression	CITED2	IDA		Human	PMID:15051727
Biological Process	GO:0010629	negative regulation of gene expression	Cited2	IMP		Rat	PMID:26240138\|RGD:13210532
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	CITED2	IMP		Human	PMID:17906695
Biological Process	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia	CITED2	IDA		Human	PMID:22735262
Biological Process	GO:0001843	neural tube closure	Cited2	IMP	MGI:MGI:2385355	Mouse	PMID:12149478
Biological Process	GO:0001841	neural tube formation	Cited2	IMP	MGI:MGI:2179740	Mouse	PMID:11694877
Biological Process	GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	Cited2	IMP		Mouse	MGI:MGI:3054669\|PMID:15475956
Biological Process	GO:0003151	outflow tract morphogenesis	Cited2	IMP		Mouse	MGI:MGI:3054669\|PMID:15475956
Biological Process	GO:0003151	outflow tract morphogenesis	Cited2	IMP	MGI:MGI:2179740	Mouse	PMID:11694877
Biological Process	GO:0007422	peripheral nervous system development	Cited2	IMP	MGI:MGI:2179740	Mouse	PMID:11694877
Biological Process	GO:0045787	positive regulation of cell cycle	Cited2	IMP		Mouse	MGI:MGI:1312962\|PMID:9811838
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	Cited2	IMP		Mouse	MGI:MGI:3813432\|PMID:17932483
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CITED2	IDA		Human	PMID:15051727
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CITED2	IDA		Human	PMID:9434189
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Cited2	IDA		Mouse	MGI:MGI:3790398\|PMID:17537799
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Cited2	IDA		Mouse	MGI:MGI:5009206\|PMID:10593900
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Cited2	IDA		Mouse	MGI:MGI:3690196\|PMID:16619037
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Cited2	IDA		Mouse	MGI:MGI:1312962\|PMID:9811838
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Cited2	IDA		Mouse	MGI:MGI:3054669\|PMID:15475956
Biological Process	GO:0010628	positive regulation of gene expression	CITED2	IDA		Human	PMID:15051727
Biological Process	GO:0010628	positive regulation of gene expression	Cited2	IMP		Rat	PMID:26240138\|RGD:13210532
Biological Process	GO:2000020	positive regulation of male gonad development	Cited2	IMP		Mouse	MGI:MGI:3851651\|PMID:19457926
Biological Process	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	CITED2	IDA		Human	PMID:15051727
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	CITED2	IDA		Human	PMID:22735262
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Cited2	IMP		Mouse	MGI:MGI:3813432\|PMID:17932483
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Cited2	IDA		Mouse	MGI:MGI:3690196\|PMID:16619037
Biological Process	GO:0061156	pulmonary artery morphogenesis	Cited2	IMP	MGI:MGI:2385355	Mouse	PMID:12149478
Biological Process	GO:0003156	regulation of animal organ formation	Cited2	IMP		Mouse	MGI:MGI:3790398\|PMID:17537799
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Cited2	IDA		Mouse	PMID:15475956
Biological Process	GO:0043627	response to estrogen	CITED2	IDA		Human	PMID:11581164
Biological Process	GO:0034405	response to fluid shear stress	CITED2	IMP		Human	PMID:12960175
Biological Process	GO:0001666	response to hypoxia	CITED2	IMP		Human	PMID:17906695
Biological Process	GO:0001666	response to hypoxia	CITED2	IDA		Human	PMID:9887100
Biological Process	GO:0009612	response to mechanical stimulus	Cited2	IEP		Rat	PMID:20826544\|RGD:5147848
Biological Process	GO:0007530	sex determination	Cited2	IMP		Mouse	MGI:MGI:3851651\|PMID:19457926
Biological Process	GO:0035914	skeletal muscle cell differentiation	Cited2	IMP		Mouse	PMID:22147266
Biological Process	GO:0048536	spleen development	Cited2	IMP		Mouse	MGI:MGI:3054669\|PMID:15475956
Biological Process	GO:0048538	thymus development	Cited2	IGI	MGI:MGI:109360	Mouse	PMID:20549734
Biological Process	GO:0048538	thymus development	Cited2	IMP	MGI:MGI:2179740	Mouse	PMID:20549734
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Cited2	IDA		Mouse	PMID:16619037
Biological Process	GO:0001829	trophectodermal cell differentiation	Cited2	IMP	MGI:MGI:2176158	Mouse	PMID:16579983
Biological Process	GO:0001944	vasculature development	Cited2	IMP	MGI:MGI:2385355	Mouse	PMID:18653562
Biological Process	GO:0001944	vasculature development	Cited2	IGI	MGI:MGI:106918	Mouse	PMID:18653562
Biological Process	GO:0001570	vasculogenesis	Cited2	IMP	MGI:MGI:2176158	Mouse	PMID:16579983
Biological Process	GO:0003281	ventricular septum development	Cited2	IMP	MGI:MGI:2176158	Mouse	PMID:15750185
Biological Process	GO:0003281	ventricular septum development	Cited2	IMP	MGI:MGI:2385355	Mouse	PMID:12149478
Biological Process	GO:0060412	ventricular septum morphogenesis	Cited2	IMP		Mouse	MGI:MGI:3054669\|PMID:15475956

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.