Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLCN1
  • Mouse genes Clcn1
  • Rat genes Clcn1
  • Zfish genes clcn1a,clcn1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clcn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CLCN1	IPI	UniProtKB:Q8IZU0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLCN1	IPI	UniProtKB:Q92624	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLCN1	IPI	UniProtKB:Q92624	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLCN1	IPI	UniProtKB:Q9NQX1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLCN1	IPI	UniProtKB:Q9UHD4	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	CLCN1	IDA		Human	PMID:26502825
Molecular Function	GO:0005247	voltage-gated chloride channel activity	CLCN1	IMP		Human	PMID:22521272
Molecular Function	GO:0005247	voltage-gated chloride channel activity	CLCN1	IMP		Human	PMID:26007199
Molecular Function	GO:0005247	voltage-gated chloride channel activity	CLCN1	IMP		Human	PMID:26502825
Molecular Function	GO:0005247	voltage-gated chloride channel activity	Clcn1	IDA		Rat	PMID:1659664|RGD:727583
Cellular Component	GO:0005886	plasma membrane	CLCN1	IDA		Human	PMID:26502825
Cellular Component	GO:0042383	sarcolemma	Clcn1	IDA		Mouse	PMID:7721815
Biological Process	GO:1902476	chloride transmembrane transport	CLCN1	IMP		Human	PMID:22521272
Biological Process	GO:1902476	chloride transmembrane transport	CLCN1	IMP		Human	PMID:26007199
Biological Process	GO:1902476	chloride transmembrane transport	CLCN1	IMP		Human	PMID:26502825
Biological Process	GO:0006821	chloride transport	Clcn1	IMP	MGI:MGI:1856316	Mouse	PMID:2453798
Biological Process	GO:0006821	chloride transport	Clcn1	IDA		Rat	PMID:1659664|RGD:727583
Biological Process	GO:0006936	muscle contraction	CLCN1	IMP		Human	PMID:22521272
Biological Process	GO:0006936	muscle contraction	CLCN1	IMP		Human	PMID:26007199
Biological Process	GO:0019227	neuronal action potential propagation	Clcn1	IMP	MGI:MGI:1856316	Mouse	PMID:2453798

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern