Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLCN3
  • Mouse genes Clcn3
  • Rat genes Clcn3
  • Zfish genes clcn3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clcn3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015297	antiporter activity	Clcn3	IDA		Mouse	MGI:MGI:6414690|PMID:28972156
Molecular Function	GO:0015297	antiporter activity	Clcn3	IDA		Mouse	MGI:MGI:6414711|PMID:24603049
Molecular Function	GO:0015297	antiporter activity	Clcn3	IDA		Mouse	MGI:MGI:6414716|PMID:26342074
Molecular Function	GO:0005254	chloride channel activity	CLCN3	IDA		Human	PMID:11274166
Molecular Function	GO:0005254	chloride channel activity	Clcn3	IDA		Rat	PMID:10915634|RGD:628537
Molecular Function	GO:0005216	monoatomic ion channel activity	Clcn3	IDA		Rat	PMID:10915634|RGD:628537
Molecular Function	GO:0030165	PDZ domain binding	CLCN3	IDA		Human	PMID:12471024
Molecular Function	GO:0005515	protein binding	CLCN3	IPI	UniProtKB:O14745	Human	PMID:12471024
Molecular Function	GO:0005515	protein binding	CLCN3	IPI	UniProtKB:Q5T2W1	Human	PMID:12471024
Molecular Function	GO:0005515	protein binding	CLCN3	IPI	UniProtKB:Q9HD26	Human	PMID:12471024
Molecular Function	GO:0005247	voltage-gated chloride channel activity	Clcn3	IDA		Rat	PMID:10915634|RGD:628537
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	Clcn3	IDA		Rat	PMID:10915634|RGD:628537
Molecular Function	GO:0072320	volume-sensitive chloride channel activity	CLCN3	IMP		Human	PMID:12183454
Cellular Component	GO:0016324	apical plasma membrane	Clcn3	IDA		Rat	PMID:12475763|RGD:628538
Cellular Component	GO:0043679	axon terminus	Clcn3	IDA		Mouse	PMID:15073168
Cellular Component	GO:0031410	cytoplasmic vesicle	CLCN3	IDA		Human	PMID:11274166
Cellular Component	GO:0005769	early endosome	CLCN3	IDA		Human	PMID:12471024
Cellular Component	GO:0031901	early endosome membrane	Clcn3	IDA		Mouse	MGI:MGI:6414705|PMID:16222710
Cellular Component	GO:0005768	endosome	Clcn3	IDA		Mouse	PMID:11182090
Cellular Component	GO:0010008	endosome membrane	Clcn3	IDA		Mouse	MGI:MGI:6414690|PMID:28972156
Cellular Component	GO:0009897	external side of plasma membrane	CLCN3	IDA		Human	PMID:11274166
Cellular Component	GO:0098978	glutamatergic synapse	Clcn3	IMP		Mouse	PMID:11182090
Cellular Component	GO:0098978	glutamatergic synapse	Clcn3	IDA		Mouse	PMID:11182090
Cellular Component	GO:0098978	glutamatergic synapse	Clcn3	IDA		Rat	PMID:17046694|RGD:13702376
Cellular Component	GO:0005794	Golgi apparatus	CLCN3	IDA		Human	PMID:12471024
Cellular Component	GO:0060077	inhibitory synapse	Clcn3	IDA		Rat	PMID:21378974|RGD:10047235
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CLCN3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005770	late endosome	CLCN3	IDA		Human	PMID:12471024
Cellular Component	GO:0031902	late endosome membrane	Clcn3	IDA		Mouse	MGI:MGI:6414705|PMID:16222710
Cellular Component	GO:0005765	lysosomal membrane	Clcn3	IDA		Mouse	MGI:MGI:6414716|PMID:26342074
Cellular Component	GO:0005765	lysosomal membrane	Clcn3	IDA		Mouse	MGI:MGI:6414690|PMID:28972156
Cellular Component	GO:0016020	membrane	CLCN3	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Clcn3	IDA		Rat	PMID:10915634|RGD:628537
Cellular Component	GO:0045335	phagocytic vesicle	CLCN3	IDA		Human	PMID:16522634
Cellular Component	GO:0005886	plasma membrane	CLCN3	IDA		Human	PMID:11274166
Cellular Component	GO:0005886	plasma membrane	Clcn3	IDA		Mouse	MGI:MGI:6414711|PMID:24603049
Cellular Component	GO:0005886	plasma membrane	Clcn3	IDA		Mouse	MGI:MGI:6414716|PMID:26342074
Cellular Component	GO:0005886	plasma membrane	Clcn3	IDA		Rat	PMID:10915634|RGD:628537
Cellular Component	GO:0045211	postsynaptic membrane	Clcn3	IDA		Rat	PMID:17046694|RGD:13702376
Cellular Component	GO:0055037	recycling endosome	Clcn3	IDA		Mouse	MGI:MGI:6414690|PMID:28972156
Cellular Component	GO:0055038	recycling endosome membrane	Clcn3	IDA		Mouse	MGI:MGI:6414716|PMID:26342074
Cellular Component	GO:0030141	secretory granule	CLCN3	IDA		Human	PMID:16522634
Cellular Component	GO:0042581	specific granule	CLCN3	IDA		Human	PMID:16522634
Cellular Component	GO:0045202	synapse	Clcn3	IDA		Rat	PMID:11182090|RGD:10047217
Cellular Component	GO:0008021	synaptic vesicle	CLCN3	IDA		Human	PMID:11182090
Cellular Component	GO:0008021	synaptic vesicle	Clcn3	IDA		Mouse	PMID:15073168
Cellular Component	GO:0008021	synaptic vesicle	Clcn3	IDA		Rat	PMID:21378974|RGD:10047235
Cellular Component	GO:0012506	vesicle membrane	CLCN3	IDA		Human	PMID:12471024
Biological Process	GO:0008344	adult locomotory behavior	Clcn3	IMP	MGI:MGI:2183297	Mouse	PMID:11182090
Biological Process	GO:1902476	chloride transmembrane transport	CLCN3	IDA		Human	PMID:11274166
Biological Process	GO:0006821	chloride transport	Clcn3	IDA		Rat	PMID:10915634|RGD:628537
Biological Process	GO:0006811	monoatomic ion transport	Clcn3	IDA		Rat	PMID:10915634|RGD:628537
Biological Process	GO:0045794	negative regulation of cell volume	CLCN3	IMP		Human	PMID:12183454
Biological Process	GO:0070050	neuron cellular homeostasis	Clcn3	IMP	MGI:MGI:2183297	Mouse	PMID:11182090
Biological Process	GO:0006911	phagocytosis, engulfment	Clcn3	IMP	MGI:MGI:2447864	Mouse	PMID:16522634
Biological Process	GO:0045494	photoreceptor cell maintenance	Clcn3	IMP	MGI:MGI:2183297	Mouse	PMID:11182090
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	Clcn3	IMP	MGI:MGI:2447864	Mouse	PMID:16522634
Biological Process	GO:0051932	synaptic transmission, GABAergic	Clcn3	IMP	MGI:MGI:2447864	Mouse	PMID:21378974
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Clcn3	IMP	MGI:MGI:2183297	Mouse	PMID:11182090
Biological Process	GO:0097401	synaptic vesicle lumen acidification	Clcn3	IMP	MGI:MGI:2447864	Mouse	PMID:21378974
Biological Process	GO:0097401	synaptic vesicle lumen acidification	Clcn3	IMP		Mouse	PMID:11182090
Biological Process	GO:0097401	synaptic vesicle lumen acidification	Clcn3	IDA		Mouse	PMID:11182090

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern