Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLCN4
  • Mouse genes Clcn4
  • Rat genes Clcn4
  • Zfish genes clcn4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clcn4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015297	antiporter activity	CLCN4	IMP		Human	PMID:23647072
Molecular Function	GO:0015297	antiporter activity	CLCN4	IMP		Human	PMID:27550844
Molecular Function	GO:0015297	antiporter activity	CLCN4	IDA		Human	PMID:28972156
Molecular Function	GO:0005254	chloride channel activity	CLCN4	IDA		Human	PMID:10564087
Molecular Function	GO:0005515	protein binding	CLCN4	IPI	UniProtKB:Q8WTS1	Human	PMID:32296183
Cellular Component	GO:0097546	ciliary base	Clcn4	IDA		Mouse	PMID:26546361
Cellular Component	GO:0005789	endoplasmic reticulum membrane	CLCN4	IDA		Human	PMID:17023393
Cellular Component	GO:0005789	endoplasmic reticulum membrane	CLCN4	IDA		Human	PMID:27550844
Cellular Component	GO:0005789	endoplasmic reticulum membrane	CLCN4	IDA		Human	PMID:28972156
Cellular Component	GO:0010008	endosome membrane	CLCN4	IDA		Human	PMID:28972156
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CLCN4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005765	lysosomal membrane	CLCN4	IDA		Human	PMID:28972156
Cellular Component	GO:0055037	recycling endosome	CLCN4	IDA		Human	PMID:28972156
Biological Process	GO:0006821	chloride transport	CLCN4	IDA		Human	PMID:10564087
Biological Process	GO:0006821	chloride transport	CLCN4	IMP		Human	PMID:23647072
Biological Process	GO:0006821	chloride transport	CLCN4	IMP		Human	PMID:25644381
Biological Process	GO:1905515	non-motile cilium assembly	Clcn4	IMP		Mouse	PMID:26546361

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern