Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLCN5
  • Mouse genes Clcn5
  • Rat genes Clcn5
  • Zfish genes clcn5a,clcn5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clcn5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	CLCN5	IPI	UniProtKB:P51795	Human	PMID:17195847
Molecular Function	GO:0005515	protein binding	CLCN5	IPI	UniProtKB:O15066	Human	PMID:19940036
Molecular Function	GO:0005247	voltage-gated chloride channel activity	CLCN5	IMP		Human	PMID:8559248
Molecular Function	GO:0005247	voltage-gated chloride channel activity	Clcn5	IDA		Rat	PMID:8626585|RGD:727659
Cellular Component	GO:0045177	apical part of cell	CLCN5	IDA		Human	PMID:14675051
Cellular Component	GO:0045177	apical part of cell	Clcn5	IDA		Mouse	MGI:MGI:4399029|PMID:14675051
Cellular Component	GO:0005829	cytosol	CLCN5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005768	endosome	Clcn5	IDA		Mouse	PMID:25008349
Cellular Component	GO:0005768	endosome	Clcn5	IDA		Rat	PMID:9815133|RGD:1599612
Cellular Component	GO:0005794	Golgi apparatus	CLCN5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005765	lysosomal membrane	CLCN5	HDA		Human	PMID:17897319
Cellular Component	GO:0016020	membrane	CLCN5	IDA		Human	PMID:14675051
Cellular Component	GO:0016020	membrane	CLCN5	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Clcn5	IDA		Rat	PMID:14675051|RGD:8553262
Cellular Component	GO:0005886	plasma membrane	CLCN5	IDA		Human	GO_REF:0000052
Biological Process	GO:0006821	chloride transport	CLCN5	IMP		Human	PMID:8559248
Biological Process	GO:0006821	chloride transport	Clcn5	IDA		Rat	PMID:8626585|RGD:727659
Biological Process	GO:0006897	endocytosis	Clcn5	IMP	MGI:MGI:2181017	Mouse	PMID:12815097
Biological Process	GO:0003014	renal system process	CLCN5	IMP		Human	PMID:8559248

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern