Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLCNKA,CLCNKB
  • Mouse genes Clcnka
  • Rat genes Clcnka
  • Zfish genes clcnk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clcnka

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005254	chloride channel activity	Clcnka	IDA		Rat	PMID:7680033|RGD:68767
Molecular Function	GO:0015108	chloride transmembrane transporter activity	clcnk	IDA		Zfish	PMID:31177533
Molecular Function	GO:0015108	chloride transmembrane transporter activity	clcnk	IGI	ZFIN:ZDB-GENE-070705-548	Zfish	PMID:31177533
Molecular Function	GO:0042802	identical protein binding	CLCNKA	IPI	UniProtKB:P51800	Human	PMID:17562318
Molecular Function	GO:0005515	protein binding	Clcnka	IPI	UniProtKB:Q8VIM4	Mouse	MGI:MGI:3690168|PMID:11734858
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	Clcnka	IDA		Rat	PMID:16849430|RGD:2313579
Cellular Component	GO:0016324	apical plasma membrane	Clcnka	IDA		Rat	PMID:7814604|RGD:2313585
Cellular Component	GO:0016323	basolateral plasma membrane	Clcnka	IDA		Mouse	PMID:11423561
Cellular Component	GO:0016323	basolateral plasma membrane	Clcnka	IDA		Rat	PMID:7814604|RGD:2313585
Cellular Component	GO:0005783	endoplasmic reticulum	Clcnka	IDA		Rat	PMID:16849430|RGD:2313579
Cellular Component	GO:0005886	plasma membrane	Clcnka	IDA		Rat	PMID:16849430|RGD:2313579
Biological Process	GO:0007589	body fluid secretion	Clcnka	IEP		Rat	PMID:7680033|RGD:68767
Biological Process	GO:0055064	chloride ion homeostasis	clcnk	IMP	ZFIN:ZDB-GENO-200505-13	Zfish	PMID:31177533
Biological Process	GO:1902476	chloride transmembrane transport	clcnk	IDA		Zfish	PMID:31177533|ZFIN:ZDB-PUB-190610-4
Biological Process	GO:0001822	kidney development	Clcnka	IEP		Rat	PMID:11479722|RGD:2313582
Biological Process	GO:0050878	regulation of body fluid levels	Clcnka	IMP	MGI:MGI:2148676	Mouse	PMID:11133517
Biological Process	GO:0072053	renal inner medulla development	Clcnka	IMP	MGI:MGI:2148676	Mouse	PMID:11423561
Biological Process	GO:0070294	renal sodium ion absorption	CLCNKB	IMP		Human	PMID:9326936
Biological Process	GO:0051592	response to calcium ion	Clcnka	IEP		Rat	PMID:7814604|RGD:2313585
Biological Process	GO:0009268	response to pH	Clcnka	IEP		Rat	PMID:7814604|RGD:2313585
Biological Process	GO:0009414	response to water deprivation	Clcnka	IEP		Rat	PMID:7680033|RGD:68767

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern