Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLDN4
  • Mouse genes Cldn13
  • Rat genes
  • Zfish genes cldna,cldnb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cldn13

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:P01558	Human	PMID:27647526
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:O15552	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:P32942	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:P48165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q4KMG9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q5SR56	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q5TGU0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q86T13	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q8IWR1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q8N9I0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q8NBJ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Cellular Component	GO:0005923	bicellular tight junction	CLDN4	IDA		Human	PMID:23407391
Cellular Component	GO:0005911	cell-cell junction	CLDN4	IDA		Human	PMID:18774778
Cellular Component	GO:0016328	lateral plasma membrane	Cldn13	IDA		Mouse	PMID:16651389
Cellular Component	GO:0005886	plasma membrane	CLDN4	IDA		Human	PMID:20375010
Cellular Component	GO:0005886	plasma membrane	CLDN4	IMP		Human	PMID:23407391
Cellular Component	GO:0070160	tight junction	CLDN4	IDA		Human	PMID:30734065
Biological Process	GO:0061436	establishment of skin barrier	CLDN4	IMP		Human	PMID:23407391
Biological Process	GO:0048884	neuromast development	cldnb	IMP	ZFIN:ZDB-MRPHLNO-100503-20	Zfish	PMID:19289112
Biological Process	GO:0030335	positive regulation of cell migration	CLDN4	IMP		Human	PMID:16103090
Biological Process	GO:1905050	positive regulation of metallopeptidase activity	CLDN4	IMP		Human	PMID:16103090
Biological Process	GO:0090303	positive regulation of wound healing	CLDN4	IMP		Human	PMID:16103090
Biological Process	GO:0022604	regulation of cell morphogenesis	CLDN4	IMP		Human	PMID:16103090
Biological Process	GO:0002028	regulation of sodium ion transport	cldnb	IMP	ZFIN:ZDB-MRPHLNO-130528-1	Zfish	PMID:23364531

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern