Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLDN18
  • Mouse genes Cldn18
  • Rat genes Cldn18
  • Zfish genes cldn18
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cldn18

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CLDN18	IPI	UniProtKB:Q01453	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN18	IPI	UniProtKB:Q08426	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cldn18	IPI	PR:Q9Z0U1	Mouse	PMID:22437732
Cellular Component	GO:0070160	tight junction	Cldn18	IDA		Mouse	MGI:MGI:6449952|PMID:22079592
Biological Process	GO:0048565	digestive tract development	Cldn18	IMP	MGI:MGI:5007067	Mouse	PMID:22437732
Biological Process	GO:0045779	negative regulation of bone resorption	Cldn18	IMP	MGI:MGI:5007067	Mouse	PMID:22437732
Biological Process	GO:2001205	negative regulation of osteoclast development	Cldn18	IMP	MGI:MGI:5007067	Mouse	PMID:22437732
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	Cldn18	IDA		Mouse	PMID:22437732
Biological Process	GO:0034504	protein localization to nucleus	Cldn18	IDA		Mouse	PMID:22437732
Biological Process	GO:0045471	response to ethanol	Cldn18	IEP		Rat	PMID:17889313|RGD:11344881
Biological Process	GO:0120192	tight junction assembly	Cldn18	IMP		Mouse	MGI:MGI:6449952|PMID:22079592
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	Cldn18	IMP	MGI:MGI:5007067	Mouse	PMID:22437732

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern