Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLDN3
  • Mouse genes Cldn3
  • Rat genes Cldn3
  • Zfish genes cldn3c,cldn3d,cldne
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cldn3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	CLDN3	IPI	UniProtKB:O15551	Human	PMID:25849148
Molecular Function	GO:0042802	identical protein binding	Cldn3	IPI	UniProtKB:Q9Z0G9	Mouse	MGI:MGI:3513972|PMID:10562289
Molecular Function	GO:0005515	protein binding	CLDN3	IPI	UniProtKB:O95832	Human	PMID:25849148
Molecular Function	GO:0005515	protein binding	Cldn3	IPI	UniProtKB:P39447|UniProtKB:Q9QXY1|UniProtKB:Q9Z0U1	Mouse	MGI:MGI:1350677|PMID:10601346
Molecular Function	GO:0005515	protein binding	Cldn3	IPI	UniProtKB:O88551|UniProtKB:O88552	Mouse	MGI:MGI:3513972|PMID:10562289
Molecular Function	GO:0005515	protein binding	Cldn3	IPI	UniProtKB:P01558	Mouse	MGI:MGI:5917869|PMID:25678664
Cellular Component	GO:0043296	apical junction complex	CLDN3	IMP		Human	PMID:27593915
Cellular Component	GO:0016327	apicolateral plasma membrane	Cldn3	IDA		Mouse	MGI:MGI:1355488|PMID:9892664
Cellular Component	GO:0005923	bicellular tight junction	CLDN3	IDA		Human	PMID:25849148
Cellular Component	GO:0005923	bicellular tight junction	Cldn3	IDA		Mouse	MGI:MGI:1355488|PMID:9892664
Cellular Component	GO:0005923	bicellular tight junction	Cldn3	IDA		Mouse	MGI:MGI:5499697|PMID:22696678
Cellular Component	GO:0005923	bicellular tight junction	Cldn3	IDA		Mouse	PMID:22275141
Cellular Component	GO:0005923	bicellular tight junction	Cldn3	IDA		Mouse	PMID:22155109
Cellular Component	GO:0005923	bicellular tight junction	Cldn3	IDA		Mouse	PMID:24889144
Cellular Component	GO:0005923	bicellular tight junction	Cldn3	IDA		Mouse	PMID:16520537
Cellular Component	GO:0005923	bicellular tight junction	Cldn3	IDA		Rat	PMID:11159882|RGD:727233
Cellular Component	GO:0005911	cell-cell junction	CLDN3	IDA		Human	PMID:18774778
Cellular Component	GO:0005911	cell-cell junction	Cldn3	IDA		Mouse	MGI:MGI:6368952|PMID:12734665
Cellular Component	GO:0005737	cytoplasm	Cldn3	IDA		Rat	PMID:21373849|RGD:11344880
Cellular Component	GO:0016328	lateral plasma membrane	Cldn3	IDA		Mouse	PMID:22275141
Cellular Component	GO:0016328	lateral plasma membrane	Cldn3	IDA		Rat	PMID:19929946|RGD:2325127
Cellular Component	GO:0032991	protein-containing complex	CLDN3	IDA		Human	PMID:25849148
Cellular Component	GO:0070160	tight junction	CLDN3	IMP		Human	PMID:20655293
Cellular Component	GO:0070160	tight junction	CLDN3	IDA		Human	PMID:30734065
Biological Process	GO:0031532	actin cytoskeleton reorganization	CLDN3	IMP		Human	PMID:27593915
Biological Process	GO:0070830	bicellular tight junction assembly	CLDN3	IMP		Human	PMID:25849148
Biological Process	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	Cldn3	IDA		Mouse	MGI:MGI:3687671|PMID:10508613
Biological Process	GO:0034331	cell junction maintenance	Cldn3	IMP		Mouse	MGI:MGI:6368952|PMID:12734665
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	cldne	IMP	ZFIN:ZDB-MRPHLNO-100521-11	Zfish	PMID:20014098
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	cldne	IMP	ZFIN:ZDB-MRPHLNO-100521-10	Zfish	PMID:20014098
Biological Process	GO:0003382	epithelial cell morphogenesis	Cldn3	IDA		Mouse	MGI:MGI:5499697|PMID:22696678
Biological Process	GO:0014045	establishment of endothelial blood-brain barrier	Cldn3	IMP		Mouse	MGI:MGI:6368952|PMID:12734665
Biological Process	GO:0031101	fin regeneration	cldn3d	IMP	ZFIN:ZDB-MRPHLNO-160627-5	Zfish	PMID:26933814
Biological Process	GO:0030336	negative regulation of cell migration	CLDN3	IMP		Human	PMID:27593915
Biological Process	GO:0008285	negative regulation of cell population proliferation	CLDN3	IMP		Human	PMID:27593915
Biological Process	GO:0010629	negative regulation of gene expression	CLDN3	IMP		Human	PMID:27593915
Biological Process	GO:0061045	negative regulation of wound healing	CLDN3	IMP		Human	PMID:27593915
Biological Process	GO:0003407	neural retina development	cldn3c	IMP	ZFIN:ZDB-MRPHLNO-210702-1	Zfish	PMID:32866532
Biological Process	GO:0003407	neural retina development	cldn3c	IMP	ZFIN:ZDB-MRPHLNO-210702-2	Zfish	PMID:32866532
Biological Process	GO:0035678	neuromast hair cell morphogenesis	cldn3c	IMP	ZFIN:ZDB-GENO-230126-5	Zfish	PMID:34046408
Biological Process	GO:0035678	neuromast hair cell morphogenesis	cldn3c	IMP	ZFIN:ZDB-MRPHLNO-220318-1	Zfish	PMID:34046408
Biological Process	GO:1903348	positive regulation of bicellular tight junction assembly	CLDN3	IMP		Human	PMID:20655293
Biological Process	GO:1901890	positive regulation of cell junction assembly	CLDN3	IMP		Human	PMID:27593915
Biological Process	GO:0030335	positive regulation of cell migration	CLDN3	IMP		Human	PMID:16103090
Biological Process	GO:0010628	positive regulation of gene expression	CLDN3	IMP		Human	PMID:27593915
Biological Process	GO:1905050	positive regulation of metallopeptidase activity	CLDN3	IMP		Human	PMID:16103090
Biological Process	GO:0001934	positive regulation of protein phosphorylation	CLDN3	IMP		Human	PMID:27593915
Biological Process	GO:0090303	positive regulation of wound healing	CLDN3	IMP		Human	PMID:16103090
Biological Process	GO:0022604	regulation of cell morphogenesis	CLDN3	IMP		Human	PMID:16103090
Biological Process	GO:0090559	regulation of membrane permeability	CLDN3	IMP		Human	PMID:20655293
Biological Process	GO:0150111	regulation of transepithelial transport	CLDN3	IMP		Human	PMID:27593915
Biological Process	GO:0045471	response to ethanol	Cldn3	IEP		Rat	PMID:17889313|RGD:11344881
Biological Process	GO:0140459	response to Gram-positive bacterium	Cldn3	IEP		Rat	PMID:20501441|RGD:2324672
Biological Process	GO:0001666	response to hypoxia	CLDN3	IEP		Human	PMID:15174142
Biological Process	GO:0007605	sensory perception of sound	cldn3c	IMP	ZFIN:ZDB-MRPHLNO-220318-1	Zfish	PMID:34046408
Biological Process	GO:0060116	vestibular receptor cell morphogenesis	cldn3c	IMP	ZFIN:ZDB-MRPHLNO-220318-1	Zfish	PMID:34046408
Biological Process	GO:0060116	vestibular receptor cell morphogenesis	cldn3c	IMP	ZFIN:ZDB-GENO-230126-5	Zfish	PMID:34046408

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern