Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cldn4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes CLDN4
- Mouse genes Cldn4
- Rat genes Cldn4
- Zfish genes cldn29,cldna,cldnb,cldnd,cldne
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cldn4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005254	chloride channel activity	Cldn4	IMP		Mouse	MGI:MGI:4837608\|PMID:20921420
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:P01558	Human	PMID:27647526
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:O15552	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:P32942	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:P48165	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q3SXY8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q4KMG9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q5SR56	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q5TGU0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q86T13	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q8IWR1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q8N9I0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q8NBJ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN4	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cldn4	IPI	UniProtKB:P39447\|UniProtKB:Q9QXY1\|UniProtKB:Q9Z0U1	Mouse	MGI:MGI:1350677\|PMID:10601346
Molecular Function	GO:0005515	protein binding	Cldn4	IPI	UniProtKB:Q9Z260	Mouse	MGI:MGI:4837608\|PMID:20921420
Cellular Component	GO:0016324	apical plasma membrane	Cldn4	IDA		Rat	PMID:17375208\|RGD:2317600
Cellular Component	GO:0016327	apicolateral plasma membrane	Cldn4	IDA		Mouse	MGI:MGI:1355488\|PMID:9892664
Cellular Component	GO:0016327	apicolateral plasma membrane	Cldn4	IDA		Rat	PMID:15068973\|RGD:2317604
Cellular Component	GO:0009925	basal plasma membrane	Cldn4	IDA		Rat	PMID:15447685\|RGD:2317603
Cellular Component	GO:0005923	bicellular tight junction	CLDN4	IDA		Human	PMID:23407391
Cellular Component	GO:0005923	bicellular tight junction	Cldn4	IDA		Mouse	MGI:MGI:5499697\|PMID:22696678
Cellular Component	GO:0005923	bicellular tight junction	Cldn4	IDA		Mouse	MGI:MGI:4837608\|PMID:20921420
Cellular Component	GO:0005923	bicellular tight junction	Cldn4	IDA		Mouse	MGI:MGI:1355488\|PMID:9892664
Cellular Component	GO:0005923	bicellular tight junction	Cldn4	IDA		Mouse	PMID:15775979
Cellular Component	GO:0005923	bicellular tight junction	Cldn4	IDA		Mouse	PMID:16520537
Cellular Component	GO:0005923	bicellular tight junction	Cldn4	IDA		Mouse	PMID:23610556
Cellular Component	GO:0005911	cell-cell junction	CLDN4	IDA		Human	PMID:18774778
Cellular Component	GO:0016328	lateral plasma membrane	Cldn4	IDA		Rat	PMID:17375208\|RGD:2317600
Cellular Component	GO:0005886	plasma membrane	CLDN4	IDA		Human	PMID:20375010
Cellular Component	GO:0005886	plasma membrane	CLDN4	IMP		Human	PMID:23407391
Cellular Component	GO:0005886	plasma membrane	Cldn4	IDA		Mouse	PMID:15775979
Cellular Component	GO:0070160	tight junction	CLDN4	IDA		Human	PMID:30734065
Cellular Component	GO:0070160	tight junction	Cldn4	IDA		Mouse	MGI:MGI:6369916\|PMID:30734065
Biological Process	GO:0007623	circadian rhythm	Cldn4	IEP		Rat	PMID:20091493\|RGD:8693638
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	cldne	IMP	ZFIN:ZDB-MRPHLNO-100521-11	Zfish	PMID:20014098
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	cldne	IMP	ZFIN:ZDB-MRPHLNO-100521-10	Zfish	PMID:20014098
Biological Process	GO:0061436	establishment of skin barrier	CLDN4	IMP		Human	PMID:23407391
Biological Process	GO:0007565	female pregnancy	Cldn4	IEP		Rat	PMID:19555995\|RGD:2317597
Biological Process	GO:0048884	neuromast development	cldnb	IMP	ZFIN:ZDB-MRPHLNO-100503-20	Zfish	PMID:19289112
Biological Process	GO:0030335	positive regulation of cell migration	CLDN4	IMP		Human	PMID:16103090
Biological Process	GO:1905050	positive regulation of metallopeptidase activity	CLDN4	IMP		Human	PMID:16103090
Biological Process	GO:0090303	positive regulation of wound healing	CLDN4	IMP		Human	PMID:16103090
Biological Process	GO:0022604	regulation of cell morphogenesis	CLDN4	IMP		Human	PMID:16103090
Biological Process	GO:0002028	regulation of sodium ion transport	cldnb	IMP	ZFIN:ZDB-MRPHLNO-130528-1	Zfish	PMID:23364531
Biological Process	GO:0070293	renal absorption	Cldn4	IMP		Mouse	MGI:MGI:4837608\|PMID:20921420
Biological Process	GO:0032570	response to progesterone	Cldn4	IEP		Rat	PMID:19555995\|RGD:2317597

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.