Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLDN5
  • Mouse genes Cldn5
  • Rat genes Cldn5
  • Zfish genes cldn5a,cldn5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cldn5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:O95832	Human	PMID:25323998
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:P57739	Human	PMID:25323998
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:A0PK11	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:O43561-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:O60636	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:O95183	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:P02724	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:P02787	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:P11686	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:P29972	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:P30301	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:P40313	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:P52803	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q01453	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q04941	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q07325	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q08426	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q13326	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q5BJH2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q6UX41-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q6ZP80	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q7Z2K6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q8NBI2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q8TAF8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q8WZ59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q969S0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q96GM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q9BT09	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q9BZL3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q9H0R3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q9NS64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q9NV12	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q9NZ01	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q9P0B6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q9P0S9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q9UKR5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q9Y548	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLDN5	IPI	UniProtKB:Q9Y5Q5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cldn5	IPI	UniProtKB:P39447|UniProtKB:Q9QXY1|UniProtKB:Q9Z0U1	Mouse	MGI:MGI:1350677|PMID:10601346
Cellular Component	GO:0043296	apical junction complex	cldn5a	IMP	ZFIN:ZDB-MRPHLNO-100525-1	Zfish	PMID:20080584
Cellular Component	GO:0016327	apicolateral plasma membrane	CLDN5	IDA		Human	PMID:9892664
Cellular Component	GO:0005923	bicellular tight junction	CLDN5	IDA		Human	PMID:25816133
Cellular Component	GO:0005923	bicellular tight junction	CLDN5	IDA		Human	PMID:9892664
Cellular Component	GO:0005923	bicellular tight junction	Cldn5	IDA		Mouse	PMID:22946046
Cellular Component	GO:0005923	bicellular tight junction	Cldn5	IDA		Mouse	PMID:22275141
Cellular Component	GO:0005911	cell-cell junction	CLDN5	IDA		Human	PMID:18065521
Cellular Component	GO:0005911	cell-cell junction	CLDN5	IDA		Human	PMID:21168935
Cellular Component	GO:0005911	cell-cell junction	CLDN5	IDA		Human	PMID:23288152
Cellular Component	GO:0005911	cell-cell junction	CLDN5	IDA		Human	PMID:23626836
Cellular Component	GO:0005911	cell-cell junction	CLDN5	IMP		Human	PMID:25753039
Cellular Component	GO:0005911	cell-cell junction	Cldn5	IDA		Mouse	MGI:MGI:6368952|PMID:12734665
Cellular Component	GO:0030864	cortical actin cytoskeleton	CLDN5	IDA		Human	PMID:25816133
Cellular Component	GO:0016328	lateral plasma membrane	Cldn5	IDA		Rat	PMID:19929946|RGD:2325127
Cellular Component	GO:0033270	paranode region of axon	Cldn5	IDA		Rat	PMID:12403818|RGD:634852
Cellular Component	GO:0005886	plasma membrane	CLDN5	IDA		Human	PMID:25978380
Cellular Component	GO:0005886	plasma membrane	CLDN5	IDA		Human	PMID:23137377
Cellular Component	GO:0005886	plasma membrane	Cldn5	IDA		Mouse	MGI:MGI:5796260|PMID:25978380
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	Cldn5	IDA		Rat	PMID:12403818|RGD:634852
Cellular Component	GO:0070160	tight junction	CLDN5	IDA		Human	PMID:30734065
Cellular Component	GO:0070160	tight junction	Cldn5	IDA		Mouse	MGI:MGI:6369916|PMID:30734065
Biological Process	GO:0007043	cell-cell junction assembly	CLDN5	IMP		Human	PMID:23288152
Biological Process	GO:0061371	determination of heart left/right asymmetry	cldn5a	IMP	ZFIN:ZDB-MRPHLNO-180212-4	Zfish	PMID:28771527
Biological Process	GO:0061371	determination of heart left/right asymmetry	cldn5a	IMP	ZFIN:ZDB-CRISPR-180212-2	Zfish	PMID:28771527
Biological Process	GO:0061371	determination of heart left/right asymmetry	cldn5a	IMP	ZFIN:ZDB-MRPHLNO-100525-1	Zfish	PMID:28771527
Biological Process	GO:0061371	determination of heart left/right asymmetry	cldn5a	IMP	ZFIN:ZDB-CRISPR-180212-1	Zfish	PMID:28771527
Biological Process	GO:0007368	determination of left/right symmetry	cldn5a	IMP	ZFIN:ZDB-MRPHLNO-180212-4	Zfish	PMID:28771527
Biological Process	GO:1990963	establishment of blood-retinal barrier	CLDN5	IMP		Human	PMID:25323998
Biological Process	GO:0061028	establishment of endothelial barrier	cldn5a	IMP	ZFIN:ZDB-MRPHLNO-100525-1	Zfish	PMID:20080584
Biological Process	GO:0061028	establishment of endothelial barrier	cldn5a	IMP	ZFIN:ZDB-MRPHLNO-100525-1	Zfish	PMID:20653957
Biological Process	GO:0070121	Kupffer's vesicle development	cldn5a	IMP	ZFIN:ZDB-MRPHLNO-180212-4	Zfish	PMID:28771527
Biological Process	GO:0035633	maintenance of blood-brain barrier	CLDN5	IMP		Human	PMID:28961379
Biological Process	GO:0042552	myelination	Cldn5	IPI	RGD:3105	Rat	PMID:12403818|RGD:634852
Biological Process	GO:0016525	negative regulation of angiogenesis	CLDN5	IMP		Human	PMID:25323998
Biological Process	GO:0030336	negative regulation of cell migration	CLDN5	IMP		Human	PMID:25323998
Biological Process	GO:0030336	negative regulation of cell migration	CLDN5	IMP		Human	PMID:28961379
Biological Process	GO:0010629	negative regulation of gene expression	CLDN5	IMP		Human	PMID:25323998
Biological Process	GO:0010629	negative regulation of gene expression	Cldn5	IMP		Mouse	MGI:MGI:6369916|PMID:30734065
Biological Process	GO:0043116	negative regulation of vascular permeability	CLDN5	IMP		Human	PMID:28961379
Biological Process	GO:1903348	positive regulation of bicellular tight junction assembly	CLDN5	IMP		Human	PMID:25323998
Biological Process	GO:0008284	positive regulation of cell population proliferation	CLDN5	IMP		Human	PMID:28961379
Biological Process	GO:1903142	positive regulation of establishment of endothelial barrier	CLDN5	IMP		Human	PMID:23288152
Biological Process	GO:0010628	positive regulation of gene expression	CLDN5	IMP		Human	PMID:25323998
Biological Process	GO:0010628	positive regulation of gene expression	Cldn5	IMP		Mouse	MGI:MGI:6369916|PMID:30734065
Biological Process	GO:0032092	positive regulation of protein binding	CLDN5	IMP		Human	PMID:25323998
Biological Process	GO:0045471	response to ethanol	Cldn5	IEP		Rat	PMID:17889313|RGD:11344881
Biological Process	GO:0120192	tight junction assembly	Cldn5	IMP		Mouse	MGI:MGI:6369916|PMID:30734065
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	CLDN5	IDA		Human	PMID:21168935

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern