Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLEC4E
  • Mouse genes Clec4e
  • Rat genes Clec4e
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clec4e

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	CLEC4E	IDA		Human	PMID:24101491
Molecular Function	GO:0051861	glycolipid binding	Clec4e	IPI	CHEBI:82624	Mouse	MGI:MGI:4415080|PMID:20008526
Molecular Function	GO:0038187	pattern recognition receptor activity	CLEC4E	IDA		Human	PMID:24101491
Molecular Function	GO:0038187	pattern recognition receptor activity	Clec4e	IDA		Mouse	MGI:MGI:4415080|PMID:20008526
Molecular Function	GO:0038187	pattern recognition receptor activity	Clec4e	IMP		Mouse	MGI:MGI:3796003|PMID:18490740
Molecular Function	GO:0005515	protein binding	CLEC4E	IPI	UniProtKB:Q07325	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLEC4E	IPI	UniProtKB:Q16617	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLEC4E	IPI	UniProtKB:Q92520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Clec4e	IPI	UniProtKB:P20491|UniProtKB:Q8BIH0	Mouse	MGI:MGI:3817341|PMID:18776906
Molecular Function	GO:0005515	protein binding	Clec4e	IPI	UniProtKB:P20411|UniProtKB:Q69FH1	Rat	PMID:23921530|RGD:13838792
Molecular Function	GO:0038023	signaling receptor activity	Clec4e	IDA		Mouse	MGI:MGI:3817341|PMID:18776906
Cellular Component	GO:0016020	membrane	CLEC4E	IDA		Human	PMID:24101491
Cellular Component	GO:0030670	phagocytic vesicle membrane	Clec4e	IDA		Mouse	MGI:MGI:3796003|PMID:18490740
Cellular Component	GO:0005886	plasma membrane	Clec4e	IDA		Mouse	MGI:MGI:3796003|PMID:18490740
Biological Process	GO:0061760	antifungal innate immune response	Clec4e	IMP		Mouse	MGI:MGI:3796003|PMID:18490740
Biological Process	GO:0042742	defense response to bacterium	Clec4e	IMP	MGI:MGI:5013826	Mouse	PMID:23602766
Biological Process	GO:0038094	Fc-gamma receptor signaling pathway	Clec4e	IDA		Mouse	PMID:23602766
Biological Process	GO:0006955	immune response	Clec4e	IMP		Mouse	MGI:MGI:5009372|PMID:19171887
Biological Process	GO:0045087	innate immune response	Clec4e	IDA		Mouse	MGI:MGI:4415080|PMID:20008526
Biological Process	GO:0045087	innate immune response	Clec4e	IMP	MGI:MGI:5013826	Mouse	PMID:23602766
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	CLEC4E	IMP		Human	PMID:24101491
Biological Process	GO:0001819	positive regulation of cytokine production	Clec4e	IDA		Mouse	MGI:MGI:3817341|PMID:18776906
Biological Process	GO:0002292	T cell differentiation involved in immune response	Clec4e	IMP	MGI:MGI:5013826	Mouse	PMID:23602766

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern