Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLIC4
  • Mouse genes Clic4
  • Rat genes Clic4
  • Zfish genes clic4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clic4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005254	chloride channel activity	Clic4	IDA		Rat	PMID:12237120|RGD:632350
Molecular Function	GO:0005515	protein binding	CLIC4	IPI	UniProtKB:P12814	Human	PMID:10793131
Molecular Function	GO:0005515	protein binding	CLIC4	IPI	UniProtKB:Q99996	Human	PMID:12163479
Molecular Function	GO:0005515	protein binding	CLIC4	IPI	UniProtKB:Q4KMQ1-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CLIC4	IPI	UniProtKB:Q4KMQ1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Clic4	IPI	UniProtKB:P70181	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Clic4	IPI	RGD:3980	Rat	PMID:11563969|RGD:1625718
Molecular Function	GO:0044877	protein-containing complex binding	Clic4	IPI	RGD:3980|RGD:71096	Rat	PMID:11563969|RGD:1625718
Cellular Component	GO:0045177	apical part of cell	CLIC4	IDA		Human	PMID:14569596
Cellular Component	GO:0009986	cell surface	CLIC4	IDA		Human	PMID:14569596
Cellular Component	GO:0005911	cell-cell junction	CLIC4	IDA		Human	PMID:14569596
Cellular Component	GO:0005813	centrosome	CLIC4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	CLIC4	IDA		Human	PMID:14569596
Cellular Component	GO:0005737	cytoplasm	CLIC4	IDA		Human	PMID:10793131
Cellular Component	GO:0005737	cytoplasm	CLIC4	IDA		Human	PMID:14569596
Cellular Component	GO:0005829	cytosol	CLIC4	IDA		Human	PMID:10026142
Cellular Component	GO:0005829	cytosol	CLIC4	IDA		Human	PMID:19776349
Cellular Component	GO:0070062	extracellular exosome	CLIC4	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CLIC4	HDA		Human	PMID:20458337
Cellular Component	GO:0015630	microtubule cytoskeleton	CLIC4	IDA		Human	PMID:14569596
Cellular Component	GO:0005902	microvillus	CLIC4	IDA		Human	PMID:14569596
Cellular Component	GO:0030496	midbody	CLIC4	IDA		Human	PMID:14569596
Cellular Component	GO:0005739	mitochondrion	CLIC4	IDA		Human	PMID:14569596
Cellular Component	GO:0005739	mitochondrion	Clic4	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Clic4	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Clic4	IDA		Mouse	PMID:10593946
Cellular Component	GO:0016363	nuclear matrix	CLIC4	IDA		Human	PMID:14569596
Cellular Component	GO:0048471	perinuclear region of cytoplasm	CLIC4	IDA		Human	PMID:14569596
Cellular Component	GO:0005886	plasma membrane	CLIC4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CLIC4	IDA		Human	PMID:19776349
Biological Process	GO:0001525	angiogenesis	Clic4	IMP	MGI:MGI:3838012	Mouse	PMID:19197003
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Clic4	IMP	MGI:MGI:3838012	Mouse	PMID:19197003
Biological Process	GO:0071277	cellular response to calcium ion	CLIC4	IMP		Human	PMID:17636002
Biological Process	GO:0001886	endothelial cell morphogenesis	Clic4	IMP	MGI:MGI:3838012	Mouse	PMID:19197003
Biological Process	GO:0009566	fertilization	Clic4	IMP		Mouse	PMID:19197003
Biological Process	GO:0030216	keratinocyte differentiation	CLIC4	IMP		Human	PMID:17636002
Biological Process	GO:0030216	keratinocyte differentiation	Clic4	IMP		Mouse	MGI:MGI:3723330|PMID:17636002
Biological Process	GO:0035264	multicellular organism growth	Clic4	IMP	MGI:MGI:3838012	Mouse	PMID:19197003
Biological Process	GO:0030336	negative regulation of cell migration	CLIC4	IDA		Human	PMID:12163372
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	Clic4	IMP	MGI:MGI:3838012	Mouse	PMID:19197003
Biological Process	GO:0007035	vacuolar acidification	Clic4	IMP	MGI:MGI:3838012	Mouse	PMID:19197003

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern