Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLK2
  • Mouse genes Clk2
  • Rat genes Clk2,Scamp3
  • Zfish genes clk2a,clk2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	CLK2	IPI	UniProtKB:P49760	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	CLK2	IPI	UniProtKB:P49760	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P49761	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P84586	Human	PMID:19282290
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P31749	Human	PMID:20682768
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P49761	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8TAD8	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P08621	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q14498	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:D3DU92	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:O00560	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:O14978	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:O95198	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P14373	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P42892	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P49761	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P78362	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q01081-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q14498	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q15696	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q53GI3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q53SE7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q7KZS0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8IYB3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8N684	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8NAV1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8TAD8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8TBB1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8TD17	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8WTR7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q96MU7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9BUV0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9BYD3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9P127	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8IYB3	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8TBB1	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8TBB1	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9BUV0	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:B2RWP4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:O76064	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:O95198	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P04553	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P08621	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P42892	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P49759-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P49761	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P52737	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P84103	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q08426	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q14498	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q15287	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q15696	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q7KZS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q86XT4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8IYI8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8N2M8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8N8L2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8TAD8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8TD17	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8WUQ7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q96EG3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q96H86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q96MU7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q96NG5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q96PQ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9BUV0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9BX10	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9BZE9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9C0F3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9H5H4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9P127	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9UBU9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q9Y5A6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:P14373	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CLK2	IPI	UniProtKB:Q8TAD8	Human	PMID:32707033
Molecular Function	GO:0004674	protein serine/threonine kinase activity	CLK2	IDA		Human	PMID:10480872
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Clk2	IDA		Mouse	MGI:MGI:1096966|PMID:9307018
Molecular Function	GO:0004713	protein tyrosine kinase activity	Clk2	IDA		Mouse	PMID:9307018
Cellular Component	GO:0016604	nuclear body	CLK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CLK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CLK2	IDA		Human	PMID:28289210
Cellular Component	GO:0005634	nucleus	CLK2	IDA		Human	PMID:9637771
Cellular Component	GO:0005634	nucleus	Clk2	IDA		Mouse	PMID:9307018
Biological Process	GO:0045721	negative regulation of gluconeogenesis	Clk2	IMP		Mouse	MGI:MGI:4429735|PMID:20074525
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Clk2	IDA		Mouse	PMID:9307018
Biological Process	GO:0046777	protein autophosphorylation	Clk2	IDA		Mouse	MGI:MGI:5294317|PMID:9852100
Biological Process	GO:0046777	protein autophosphorylation	Clk2	IDA		Mouse	PMID:9307018
Biological Process	GO:0006468	protein phosphorylation	CLK2	IDA		Human	PMID:20682768
Biological Process	GO:0006468	protein phosphorylation	CLK2	IDA		Human	PMID:28289210
Biological Process	GO:0006468	protein phosphorylation	CLK2	IDA		Human	PMID:9637771
Biological Process	GO:0006468	protein phosphorylation	Clk2	IDA		Mouse	MGI:MGI:4429735|PMID:20074525
Biological Process	GO:0043484	regulation of RNA splicing	CLK2	IDA		Human	PMID:9637771
Biological Process	GO:0010212	response to ionizing radiation	CLK2	IMP		Human	PMID:20682768
Biological Process	GO:0010033	response to organic substance	Clk2	IDA		Mouse	PMID:18400104
Biological Process	GO:0032526	response to retinoic acid	Clk2	IDA		Mouse	PMID:18400104

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern