Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLN3
  • Mouse genes Cln3
  • Rat genes Cln3
  • Zfish genes cln3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cln3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048306	calcium-dependent protein binding	Cln3	IPI	PR:Q9QXT8	Mouse	PMID:17189291
Molecular Function	GO:0051861	glycolipid binding	CLN3	IDA		Human	PMID:18317235
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:O75503	Human	PMID:12134079
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:O75503	Human	PMID:14699076
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:Q9UJC3	Human	PMID:15471887
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:O14617	Human	PMID:15598649
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:O43747	Human	PMID:15598649
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:O94973	Human	PMID:15598649
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:Q9Y2W7	Human	PMID:17189291
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:O14773|UniProtKB:Q9NWW5|UniProtKB:Q9UBY8	Human	PMID:17237713
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:Q3UMW8	Human	PMID:19941651
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:Q9Y3A5	Human	PMID:20015955
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:Q61879	Human	PMID:20850431
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:P51149	Human	PMID:22261744
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:Q14203	Human	PMID:22261744
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:Q96NA2	Human	PMID:22261744
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:Q9Y496	Human	PMID:22261744
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:Q6ZTQ4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:Q8IY31-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CLN3	IPI	UniProtKB:Q8N7X4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Cln3	IPI	UniProtKB:Q3UMW8	Mouse	MGI:MGI:5795821|PMID:19941651
Molecular Function	GO:0005515	protein binding	Cln3	IPI	PR:Q9QXT8	Mouse	PMID:17189291
Molecular Function	GO:0120146	sulfatide binding	CLN3	IDA		Human	PMID:18317235
Cellular Component	GO:0044754	autolysosome	Cln3	IDA		Mouse	MGI:MGI:3690270|PMID:16714284
Cellular Component	GO:0005776	autophagosome	Cln3	IDA		Mouse	PMID:16714284
Cellular Component	GO:0005901	caveola	CLN3	IDA		Human	PMID:15240864
Cellular Component	GO:0005901	caveola	CLN3	IMP		Human	PMID:23840424
Cellular Component	GO:0005737	cytoplasm	CLN3	IDA		Human	PMID:10191116
Cellular Component	GO:0031410	cytoplasmic vesicle	Cln3	IDA		Mouse	PMID:17189291
Cellular Component	GO:0005769	early endosome	CLN3	IDA		Human	PMID:15240864
Cellular Component	GO:0005769	early endosome	Cln3	IDA		Mouse	PMID:15588329
Cellular Component	GO:0031901	early endosome membrane	CLN3	IMP		Human	PMID:23840424
Cellular Component	GO:0005783	endoplasmic reticulum	CLN3	IDA		Human	PMID:10191111
Cellular Component	GO:0005789	endoplasmic reticulum membrane	CLN3	IDA		Human	PMID:12706816
Cellular Component	GO:0005768	endosome	Cln3	IDA		Rat	PMID:15240864|RGD:1598669
Cellular Component	GO:0005794	Golgi apparatus	CLN3	IDA		Human	PMID:10332042
Cellular Component	GO:0005794	Golgi apparatus	CLN3	IDA		Human	PMID:15240864
Cellular Component	GO:0005794	Golgi apparatus	CLN3	IMP		Human	PMID:23840424
Cellular Component	GO:0005794	Golgi apparatus	Cln3	IDA		Rat	PMID:15240864|RGD:1598669
Cellular Component	GO:0000139	Golgi membrane	CLN3	IDA		Human	PMID:10191111
Cellular Component	GO:0000139	Golgi membrane	CLN3	IDA		Human	PMID:9949212
Cellular Component	GO:0005795	Golgi stack	CLN3	IDA		Human	PMID:15240864
Cellular Component	GO:0005770	late endosome	CLN3	IDA		Human	PMID:10332042
Cellular Component	GO:0005770	late endosome	CLN3	IDA		Human	PMID:15471887
Cellular Component	GO:0005770	late endosome	CLN3	IDA		Human	PMID:22261744
Cellular Component	GO:0005770	late endosome	CLN3	IMP		Human	PMID:23840424
Cellular Component	GO:0005770	late endosome	Cln3	IDA		Mouse	PMID:15588329
Cellular Component	GO:0005765	lysosomal membrane	CLN3	IDA		Human	PMID:10332042
Cellular Component	GO:0005765	lysosomal membrane	CLN3	IMP		Human	PMID:15598649
Cellular Component	GO:0005765	lysosomal membrane	CLN3	HDA		Human	PMID:17897319
Cellular Component	GO:0005765	lysosomal membrane	CLN3	IMP		Human	PMID:23840424
Cellular Component	GO:0005765	lysosomal membrane	CLN3	IDA		Human	PMID:9384607
Cellular Component	GO:0005764	lysosome	CLN3	IDA		Human	PMID:10332042
Cellular Component	GO:0005764	lysosome	CLN3	IDA		Human	PMID:10924275
Cellular Component	GO:0005764	lysosome	CLN3	IMP		Human	PMID:14644441
Cellular Component	GO:0005764	lysosome	CLN3	IDA		Human	PMID:14699076
Cellular Component	GO:0005764	lysosome	CLN3	IDA		Human	PMID:15471887
Cellular Component	GO:0005764	lysosome	CLN3	IDA		Human	PMID:19941651
Cellular Component	GO:0005764	lysosome	Cln3	IDA		Mouse	MGI:MGI:6383759|PMID:11590129
Cellular Component	GO:0005764	lysosome	Cln3	IDA		Mouse	MGI:MGI:5795821|PMID:19941651
Cellular Component	GO:0005764	lysosome	Cln3	IDA		Mouse	PMID:15588329
Cellular Component	GO:0005764	lysosome	Cln3	IDA		Mouse	PMID:16714284
Cellular Component	GO:0016020	membrane	CLN3	IDA		Human	PMID:10191112
Cellular Component	GO:0045121	membrane raft	CLN3	IDA		Human	PMID:15240864
Cellular Component	GO:0045121	membrane raft	CLN3	IMP		Human	PMID:23840424
Cellular Component	GO:0045121	membrane raft	Cln3	IDA		Mouse	MGI:MGI:5529746|PMID:24227717
Cellular Component	GO:0043005	neuron projection	CLN3	IDA		Human	PMID:10332042
Cellular Component	GO:0043005	neuron projection	Cln3	IDA		Mouse	MGI:MGI:6383759|PMID:11590129
Cellular Component	GO:0005634	nucleus	CLN3	IDA		Human	PMID:10191116
Cellular Component	GO:0005886	plasma membrane	CLN3	IDA		Human	PMID:10191116
Cellular Component	GO:0005886	plasma membrane	CLN3	IMP		Human	PMID:14644441
Cellular Component	GO:0005886	plasma membrane	CLN3	IDA		Human	PMID:15240864
Cellular Component	GO:0005886	plasma membrane	Cln3	IDA		Rat	PMID:15240864|RGD:1598669
Cellular Component	GO:0055037	recycling endosome	CLN3	IDA		Human	PMID:15240864
Cellular Component	GO:0008021	synaptic vesicle	CLN3	IDA		Human	PMID:10332042
Cellular Component	GO:0008021	synaptic vesicle	CLN3	IDA		Human	PMID:11590129
Cellular Component	GO:0005802	trans-Golgi network	CLN3	IDA		Human	PMID:10332042
Cellular Component	GO:0005802	trans-Golgi network	CLN3	IDA		Human	PMID:15240864
Cellular Component	GO:0005802	trans-Golgi network	Cln3	IDA		Mouse	MGI:MGI:5529746|PMID:24227717
Biological Process	GO:0030036	actin cytoskeleton organization	Cln3	IMP	MGI:MGI:3759415	Mouse	PMID:24792215
Biological Process	GO:0001508	action potential	Cln3	IMP	MGI:MGI:1933976	Mouse	PMID:16412658
Biological Process	GO:0006865	amino acid transport	Cln3	IMP	MGI:MGI:1933976	Mouse	PMID:16412658
Biological Process	GO:0042987	amyloid precursor protein catabolic process	CLN3	IDA		Human	PMID:10924275
Biological Process	GO:0008306	associative learning	Cln3	IMP	MGI:MGI:2388888	Mouse	PMID:15885820
Biological Process	GO:0097352	autophagosome maturation	Cln3	IMP	MGI:MGI:2388888	Mouse	PMID:16714284
Biological Process	GO:0061909	autophagosome-lysosome fusion	Cln3	IMP		Mouse	MGI:MGI:5698740|PMID:26450516
Biological Process	GO:0007409	axonogenesis	cln3	IMP	ZFIN:ZDB-MRPHLNO-170816-1	Zfish	PMID:27327661
Biological Process	GO:0043534	blood vessel endothelial cell migration	Cln3	IMP	MGI:MGI:3759415	Mouse	PMID:24792215
Biological Process	GO:0006897	endocytosis	Cln3	IMP	MGI:MGI:3759415	Mouse	PMID:24792215
Biological Process	GO:0051649	establishment of localization in cell	Cln3	IMP	MGI:MGI:3759415	Mouse	PMID:24792215
Biological Process	GO:0046474	glycerophospholipid biosynthetic process	CLN3	IMP		Human	PMID:17482562
Biological Process	GO:0046836	glycolipid transport	CLN3	IMP		Human	PMID:18317235
Biological Process	GO:0090160	Golgi to lysosome transport	CLN3	IMP		Human	PMID:18817525
Biological Process	GO:0009992	intracellular water homeostasis	Cln3	IMP		Mouse	MGI:MGI:4455253|PMID:20219947
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	Cln3	IMP	MGI:MGI:1933976	Mouse	PMID:16483786
Biological Process	GO:1903826	L-arginine transmembrane transport	CLN3	IDA		Human	PMID:16251196
Biological Process	GO:0007611	learning or memory	Cln3	IMP		Mouse	MGI:MGI:6111006|PMID:29135436
Biological Process	GO:0007042	lysosomal lumen acidification	CLN3	IMP		Human	PMID:11722572
Biological Process	GO:0035752	lysosomal lumen pH elevation	CLN3	IDA		Human	PMID:10924275
Biological Process	GO:1905146	lysosomal protein catabolic process	Cln3	IMP		Mouse	MGI:MGI:3757820|PMID:17855597
Biological Process	GO:1905146	lysosomal protein catabolic process	Cln3	IMP		Mouse	MGI:MGI:1346962|PMID:10527801
Biological Process	GO:0007040	lysosome organization	Cln3	IMP	MGI:MGI:2388887	Mouse	PMID:15588329
Biological Process	GO:0007040	lysosome organization	Cln3	IMP	MGI:MGI:1933976	Mouse	PMID:10191119
Biological Process	GO:0007040	lysosome organization	Cln3	IMP	MGI:MGI:1933976	Mouse	PMID:10527801
Biological Process	GO:0007040	lysosome organization	Cln3	IMP	MGI:MGI:3623134	Mouse	PMID:10440905
Biological Process	GO:0007040	lysosome organization	cln3	IMP	ZFIN:ZDB-MRPHLNO-170816-1	Zfish	PMID:27327661
Biological Process	GO:0016236	macroautophagy	Cln3	IMP	MGI:MGI:2388888	Mouse	PMID:16714284
Biological Process	GO:0061024	membrane organization	Cln3	IMP	MGI:MGI:2388887	Mouse	PMID:15588329
Biological Process	GO:0043066	negative regulation of apoptotic process	CLN3	IMP		Human	PMID:15240864
Biological Process	GO:0043066	negative regulation of apoptotic process	Cln3	IMP		Mouse	MGI:MGI:6383588|PMID:10191118
Biological Process	GO:0043086	negative regulation of catalytic activity	Cln3	IMP	MGI:MGI:1933976	Mouse	PMID:17868323
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Cln3	IDA		Mouse	PMID:17189291
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	cln3	IMP	ZFIN:ZDB-MRPHLNO-170816-1	Zfish	PMID:27327661
Biological Process	GO:0045861	negative regulation of proteolysis	Cln3	IMP	MGI:MGI:1933976	Mouse	PMID:10527801
Biological Process	GO:0050885	neuromuscular process controlling balance	Cln3	IMP	MGI:MGI:1933976	Mouse	PMID:16483786
Biological Process	GO:0042133	neurotransmitter metabolic process	Cln3	IMP	MGI:MGI:1933976	Mouse	PMID:16239221
Biological Process	GO:0090384	phagosome-lysosome docking	Cln3	IMP		Mouse	MGI:MGI:5698740|PMID:26450516
Biological Process	GO:0090385	phagosome-lysosome fusion	Cln3	IMP		Mouse	MGI:MGI:5698740|PMID:26450516
Biological Process	GO:0044857	plasma membrane raft organization	Cln3	IMP		Mouse	MGI:MGI:5529746|PMID:24227717
Biological Process	GO:2001288	positive regulation of caveolin-mediated endocytosis	Cln3	IMP		Mouse	MGI:MGI:5529746|PMID:24227717
Biological Process	GO:0042998	positive regulation of Golgi to plasma membrane protein transport	Cln3	IMP		Mouse	MGI:MGI:5529746|PMID:24227717
Biological Process	GO:0048549	positive regulation of pinocytosis	Cln3	IMP		Mouse	MGI:MGI:5607692|PMID:24792215
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Cln3	IMP	MGI:MGI:3759415	Mouse	PMID:24792215
Biological Process	GO:0072657	protein localization to membrane	Cln3	IMP	MGI:MGI:3759415	Mouse	PMID:24792215
Biological Process	GO:0072659	protein localization to plasma membrane	Cln3	IMP	MGI:MGI:3759415	Mouse	PMID:24792215
Biological Process	GO:0006468	protein phosphorylation	Cln3	IMP	MGI:MGI:3759415	Mouse	PMID:24792215
Biological Process	GO:0016485	protein processing	Cln3	IMP	MGI:MGI:2388887	Mouse	PMID:15588329
Biological Process	GO:0006898	receptor-mediated endocytosis	CLN3	IMP		Human	PMID:15471887
Biological Process	GO:1900079	regulation of arginine biosynthetic process	Cln3	IMP		Mouse	MGI:MGI:4830440|PMID:19284480
Biological Process	GO:1901096	regulation of autophagosome maturation	Cln3	IMP		Mouse	MGI:MGI:5698740|PMID:26450516
Biological Process	GO:0016243	regulation of autophagosome size	Cln3	IMP		Mouse	MGI:MGI:6383362|PMID:25878248
Biological Process	GO:0010506	regulation of autophagy	Cln3	IMP		Mouse	MGI:MGI:5784638|PMID:27101989
Biological Process	GO:0106049	regulation of cellular response to osmotic stress	CLN3	IMP		Human	PMID:23840424
Biological Process	GO:0051493	regulation of cytoskeleton organization	CLN3	IMP		Human	PMID:20850431
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	Cln3	IDA		Mouse	PMID:17189291
Biological Process	GO:0010762	regulation of fibroblast migration	CLN3	IMP		Human	PMID:20850431
Biological Process	GO:0051489	regulation of filopodium assembly	Cln3	IMP	MGI:MGI:3759415	Mouse	PMID:24792215
Biological Process	GO:1905244	regulation of modification of synaptic structure	Cln3	IMP		Mouse	MGI:MGI:6256925|PMID:29780879
Biological Process	GO:1905162	regulation of phagosome maturation	Cln3	IMP		Mouse	MGI:MGI:5698740|PMID:26450516
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	Cln3	IMP		Mouse	MGI:MGI:3806728|PMID:18621045
Biological Process	GO:0070613	regulation of protein processing	CLN3	IMP		Human	PMID:10924275
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	Cln3	IMP		Mouse	MGI:MGI:6111006|PMID:29135436
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	Cln3	IMP		Mouse	MGI:MGI:6256925|PMID:29780879
Biological Process	GO:0032228	regulation of synaptic transmission, GABAergic	Cln3	IMP		Mouse	MGI:MGI:6111006|PMID:29135436
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	Cln3	IMP		Mouse	MGI:MGI:6111006|PMID:29135436
Biological Process	GO:0036359	renal potassium excretion	Cln3	IMP		Mouse	MGI:MGI:4455253|PMID:20219947
Biological Process	GO:0047496	vesicle transport along microtubule	CLN3	IMP		Human	PMID:22261744

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern