Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLN8
  • Mouse genes Cln8
  • Rat genes Cln8
  • Zfish genes cln8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cln8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097001	ceramide binding	CLN8	IDA		Human	PMID:18317235
Molecular Function	GO:0005515	protein binding	CLN8	IPI	UniProtKB:Q13286	Human	PMID:17237713
Molecular Function	GO:0005515	protein binding	Cln8	IPI	UniProtKB:Q3UMW8	Mouse	MGI:MGI:5795821|PMID:19941651
Cellular Component	GO:0005783	endoplasmic reticulum	CLN8	IDA		Human	PMID:10861296
Cellular Component	GO:0005783	endoplasmic reticulum	CLN8	IDA		Human	PMID:19941651
Cellular Component	GO:0005783	endoplasmic reticulum	Cln8	IDA		Mouse	MGI:MGI:5795821|PMID:19941651
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	CLN8	IDA		Human	PMID:10861296
Biological Process	GO:0008344	adult locomotory behavior	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:12020865
Biological Process	GO:0007628	adult walking behavior	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:7668363
Biological Process	GO:0007628	adult walking behavior	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:10215924
Biological Process	GO:0007628	adult walking behavior	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:2061715
Biological Process	GO:0007628	adult walking behavior	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:7683855
Biological Process	GO:0007628	adult walking behavior	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:3783318
Biological Process	GO:0007628	adult walking behavior	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:9918704
Biological Process	GO:0006915	apoptotic process	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:15565184
Biological Process	GO:0008306	associative learning	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:15885820
Biological Process	GO:0006672	ceramide metabolic process	CLN8	IMP		Human	PMID:16086686
Biological Process	GO:0008203	cholesterol metabolic process	CLN8	IMP		Human	PMID:16086686
Biological Process	GO:0051935	glutamate reuptake	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:9600674
Biological Process	GO:0051935	glutamate reuptake	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:8095977
Biological Process	GO:0007040	lysosome organization	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:8160780
Biological Process	GO:0007040	lysosome organization	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:10087069
Biological Process	GO:0007040	lysosome organization	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:8144516
Biological Process	GO:0007040	lysosome organization	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:7613514
Biological Process	GO:0009057	macromolecule catabolic process	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:15647513
Biological Process	GO:0007006	mitochondrial membrane organization	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:9059519
Biological Process	GO:0050881	musculoskeletal movement	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:2061715
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:15565184
Biological Process	GO:0051348	negative regulation of transferase activity	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:8873145
Biological Process	GO:0007399	nervous system development	CLN8	IMP		Human	PMID:10508524
Biological Process	GO:0060052	neurofilament cytoskeleton organization	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:2061715
Biological Process	GO:0050885	neuromuscular process controlling balance	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:9918704
Biological Process	GO:0050884	neuromuscular process controlling posture	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:2061715
Biological Process	GO:0051402	neuron apoptotic process	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:15565184
Biological Process	GO:0006644	phospholipid metabolic process	CLN8	IMP		Human	PMID:16086686
Biological Process	GO:0006644	phospholipid metabolic process	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:9245501
Biological Process	GO:0045494	photoreceptor cell maintenance	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:9151333
Biological Process	GO:0045494	photoreceptor cell maintenance	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:15565184
Biological Process	GO:0030163	protein catabolic process	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:8389815
Biological Process	GO:0019538	protein metabolic process	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:1658691
Biological Process	GO:0008361	regulation of cell size	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:15565184
Biological Process	GO:0060041	retina development in camera-type eye	Cln8	IMP		Mouse	PMID:21052544
Biological Process	GO:0060041	retina development in camera-type eye	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:15565184
Biological Process	GO:0097473	retinal rod cell apoptotic process	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:15565184
Biological Process	GO:0035176	social behavior	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:12020865
Biological Process	GO:0021523	somatic motor neuron differentiation	Cln8	IMP		Mouse	PMID:21052544
Biological Process	GO:0021522	spinal cord motor neuron differentiation	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:2061715
Biological Process	GO:0007601	visual perception	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:8282051
Biological Process	GO:0007601	visual perception	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:7683855
Biological Process	GO:0007601	visual perception	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:7668363
Biological Process	GO:0007601	visual perception	Cln8	IMP	MGI:MGI:1856959	Mouse	PMID:8125718

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern