Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLPX
  • Mouse genes Clpx
  • Rat genes Clpx
  • Zfish genes clpxa,clpxb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clpx

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Clpx	IDA		Mouse	PMID:10347188
Molecular Function	GO:0016887	ATP hydrolysis activity	CLPX	IDA		Human	PMID:22710082
Molecular Function	GO:0016887	ATP hydrolysis activity	Clpx	IDA		Mouse	PMID:10347188
Molecular Function	GO:0004176	ATP-dependent peptidase activity	CLPX	IDA		Human	PMID:16115876
Molecular Function	GO:0016504	peptidase activator activity	CLPX	IDA		Human	PMID:11923310
Molecular Function	GO:0016504	peptidase activator activity	CLPX	IDA		Human	PMID:16115876
Molecular Function	GO:0005515	protein binding	CLPX	IPI	UniProtKB:Q16740	Human	PMID:11923310
Molecular Function	GO:0005515	protein binding	CLPX	IPI	UniProtKB:Q16740:PRO_0000005516	Human	PMID:15522782
Molecular Function	GO:0005515	protein binding	CLPX	IPI	UniProtKB:Q16740	Human	PMID:16115876
Molecular Function	GO:0005515	protein binding	Clpx	IPI	PR:O88696	Mouse	PMID:10347188
Cellular Component	GO:0005829	cytosol	CLPX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009368	endopeptidase Clp complex	CLPX	IPI		Human	PMID:15522782
Cellular Component	GO:0009368	endopeptidase Clp complex	CLPX	IDA		Human	PMID:11923310
Cellular Component	GO:0009368	endopeptidase Clp complex	CLPX	IDA		Human	PMID:22710082
Cellular Component	GO:0009841	mitochondrial endopeptidase Clp complex	CLPX	IDA		Human	PMID:16115876
Cellular Component	GO:0005743	mitochondrial inner membrane	Clpx	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005759	mitochondrial matrix	CLPX	IDA		Human	PMID:10525407
Cellular Component	GO:0042645	mitochondrial nucleoid	CLPX	IDA		Human	PMID:18063578
Cellular Component	GO:0005739	mitochondrion	CLPX	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	CLPX	IDA		Human	PMID:11003706
Cellular Component	GO:0005739	mitochondrion	Clpx	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Clpx	IDA		Mouse	PMID:10347188
Cellular Component	GO:0005739	mitochondrion	Clpx	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005654	nucleoplasm	CLPX	IDA		Human	GO_REF:0000052
Biological Process	GO:0046034	ATP metabolic process	CLPX	IDA		Human	PMID:22710082
Biological Process	GO:0048821	erythrocyte development	clpxa	IMP	ZFIN:ZDB-MRPHLNO-150616-1	Zfish	PMID:25957689
Biological Process	GO:0048821	erythrocyte development	clpxa	IMP	ZFIN:ZDB-MRPHLNO-150616-2	Zfish	PMID:25957689
Biological Process	GO:0006508	proteolysis	CLPX	IDA		Human	PMID:15522782
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	CLPX	IDA		Human	PMID:16115876

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern