Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLTC
  • Mouse genes Cltc
  • Rat genes Cltc
  • Zfish genes cltca,cltcb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cltc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030506	ankyrin binding	Cltc	IDA		Rat	PMID:10585476|RGD:2303182
Molecular Function	GO:0032051	clathrin light chain binding	CLTC	IPI	UniProtKB:P09496	Human	PMID:4066749
Molecular Function	GO:0097718	disordered domain specific binding	CLTC	IPI	UniProtKB:Q05140	Human	PMID:11756460
Molecular Function	GO:0003725	double-stranded RNA binding	CLTC	IDA		Human	PMID:21266579
Molecular Function	GO:0031072	heat shock protein binding	Cltc	IDA		Rat	PMID:17978091|RGD:2303184
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	CLTC	IPI	UniProtKB:Q07954	Human	PMID:26005850
Molecular Function	GO:0042277	peptide binding	Cltc	IDA		Rat	PMID:1490999|RGD:2303177
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q14677	Human	PMID:12429846
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q01968	Human	PMID:16902405
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:P10242	Human	PMID:18548008
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:P14672	Human	PMID:19478182
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q15836	Human	PMID:19478182
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q9UJY4	Human	PMID:19478182
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q01968	Human	PMID:19536138
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:O75674	Human	PMID:19798056
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q07912	Human	PMID:19798056
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:P09496	Human	PMID:21297582
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q01968	Human	PMID:25107275
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q07954	Human	PMID:26005850
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q01968	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q07912	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q9NYZ3	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:P09496	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:O75030	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q07912	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	CLTC	IPI	UniProtKB:Q9NYZ3	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Cltc	IPI	UniProtKB:Q01968	Mouse	MGI:MGI:6094416|PMID:25107275
Molecular Function	GO:0005515	protein binding	Cltc	IPI	UniProtKB:Q15637	Mouse	MGI:MGI:5700260|PMID:26420826
Molecular Function	GO:0005515	protein binding	Cltc	IPI	PR:P39053	Mouse	PMID:23746204
Molecular Function	GO:0005515	protein binding	Cltc	IPI	PR:Q8BUV8	Mouse	PMID:24849652
Molecular Function	GO:0005515	protein binding	Cltc	IPI	UniProtKB:Q61548	Rat	PMID:11102472|RGD:8553618
Molecular Function	GO:0005515	protein binding	Cltc	IPI	RGD:1560287	Rat	PMID:11964161|RGD:727364
Molecular Function	GO:0005515	protein binding	Cltc	IPI	RGD:1602726	Rat	PMID:12213833|RGD:1303953
Molecular Function	GO:0005515	protein binding	Cltc	IPI	UniProtKB:Q01968	Rat	PMID:19536138|RGD:8554814
Molecular Function	GO:0019901	protein kinase binding	Cltc	IPI	UniProtKB:Q5S007	Mouse	MGI:MGI:4941068|PMID:21307259
Molecular Function	GO:0120283	protein serine/threonine kinase binding	Cltc	IPI	RGD:620760	Rat	PMID:20802490|RGD:152995511
Molecular Function	GO:0003723	RNA binding	CLTC	HDA		Human	PMID:22681889
Molecular Function	GO:1990381	ubiquitin-specific protease binding	CLTC	IPI	UniProtKB:O88623-2	Human	PMID:26756164
Cellular Component	GO:0030118	clathrin coat	CLTC	IMP		Human	PMID:11756460
Cellular Component	GO:0030118	clathrin coat	Cltc	IDA		Rat	PMID:1490999|RGD:2303177
Cellular Component	GO:0030118	clathrin coat	Cltc	IDA		Rat	PMID:17978091|RGD:2303184
Cellular Component	GO:0071439	clathrin complex	CLTC	IDA		Human	PMID:4066749
Cellular Component	GO:0005905	clathrin-coated pit	Cltc	IDA		Mouse	PMID:26437238
Cellular Component	GO:0030136	clathrin-coated vesicle	CLTC	IDA		Human	PMID:19478182
Cellular Component	GO:0005768	endosome	CLTC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	CLTC	HDA		Human	PMID:12519789
Cellular Component	GO:0070062	extracellular exosome	CLTC	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CLTC	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	CLTC	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	CLTC	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	CLTC	HDA		Human	PMID:23533145
Cellular Component	GO:1903561	extracellular vesicle	CLTC	HDA		Human	PMID:24769233
Cellular Component	GO:0098850	extrinsic component of synaptic vesicle membrane	Cltc	IDA		Rat	PMID:1325974|RGD:13702292
Cellular Component	GO:0005925	focal adhesion	CLTC	HDA		Human	PMID:21423176
Cellular Component	GO:0005764	lysosome	CLTC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	CLTC	HDA		Human	PMID:16210410
Cellular Component	GO:0016020	membrane	CLTC	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Cltc	IMP		Mouse	MGI:MGI:4420830|PMID:20080761
Cellular Component	GO:0030117	membrane coat	Cltc	IDA		Mouse	PMID:11879655
Cellular Component	GO:0005739	mitochondrion	Cltc	HDA		Mouse	PMID:14651853
Cellular Component	GO:0072686	mitotic spindle	CLTC	IDA		Human	GO_REF:0000052
Cellular Component	GO:1990498	mitotic spindle microtubule	CLTC	IDA		Human	PMID:21297582
Cellular Component	GO:0043209	myelin sheath	Cltc	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0098684	photoreceptor ribbon synapse	Cltc	IDA		Mouse	PMID:23785143
Cellular Component	GO:0098835	presynaptic endocytic zone membrane	Cltc	IDA		Mouse	PMID:23785143
Cellular Component	GO:0032991	protein-containing complex	CLTC	IDA		Human	PMID:21266579
Cellular Component	GO:0042383	sarcolemma	Cltc	IDA		Rat	PMID:7536412|RGD:2303181
Cellular Component	GO:0005819	spindle	CLTC	IDA		Human	PMID:15858577
Cellular Component	GO:0005819	spindle	Cltc	IDA		Rat	PMID:15858577|RGD:8553642
Cellular Component	GO:0030315	T-tubule	Cltc	IDA		Rat	PMID:7536412|RGD:2303181
Cellular Component	GO:0043195	terminal bouton	Cltc	HDA		Rat	PMID:24876496|RGD:10047219
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	CLTC	IMP		Human	PMID:26005850
Biological Process	GO:0048268	clathrin coat assembly	CLTC	IMP		Human	PMID:11756460
Biological Process	GO:0072583	clathrin-dependent endocytosis	CLTC	IMP		Human	PMID:26005850
Biological Process	GO:0007030	Golgi organization	Cltc	IMP		Rat	PMID:17065556|RGD:2303187
Biological Process	GO:0000278	mitotic cell cycle	CLTC	IMP		Human	PMID:15858577
Biological Process	GO:0000278	mitotic cell cycle	Cltc	IMP		Rat	PMID:15858577|RGD:8553642
Biological Process	GO:1900126	negative regulation of hyaluronan biosynthetic process	CLTC	IMP		Human	PMID:23509262
Biological Process	GO:1900126	negative regulation of hyaluronan biosynthetic process	CLTC	IDA		Human	PMID:24251095
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	CLTC	IMP		Human	PMID:19581412
Biological Process	GO:0001649	osteoblast differentiation	CLTC	HDA		Human	PMID:16210410
Biological Process	GO:0031623	receptor internalization	CLTC	IMP		Human	PMID:14985334
Biological Process	GO:0006898	receptor-mediated endocytosis	CLTC	IMP		Human	PMID:15858577
Biological Process	GO:0006898	receptor-mediated endocytosis	Cltc	IMP		Rat	PMID:15858577|RGD:8553642
Biological Process	GO:0060236	regulation of mitotic spindle organization	CLTC	IMP		Human	PMID:21297582
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	CLTC	IMP		Human	PMID:20065094
Biological Process	GO:0048488	synaptic vesicle endocytosis	Cltc	IDA		Rat	PMID:16982422|RGD:13702168
Biological Process	GO:0048488	synaptic vesicle endocytosis	Cltc	IMP		Rat	PMID:16982422|RGD:13702168
Biological Process	GO:0033572	transferrin transport	CLTC	IMP		Human	PMID:14985334

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern