Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CNTF
  • Mouse genes Cntf
  • Rat genes Cntf
  • Zfish genes m17
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cntf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005127	ciliary neurotrophic factor receptor binding	Cntf	IPI	RGD:1303100	Rat	PMID:1648265|RGD:1626161
Molecular Function	GO:0005125	cytokine activity	Cntf	IDA		Rat	PMID:8385113|RGD:1626160
Molecular Function	GO:0008083	growth factor activity	CNTF	IDA		Human	PMID:12643274
Molecular Function	GO:0005138	interleukin-6 receptor binding	CNTF	IPI	UniProtKB:P08887	Human	PMID:12643274
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:P40189	Human	PMID:16051226
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:P42702	Human	PMID:16051226
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:P26992	Human	PMID:18775332
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:P40189	Human	PMID:18775332
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:P42702	Human	PMID:18775332
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:P26992	Human	PMID:20584990
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:Q99523	Human	PMID:20584990
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:Q15654	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:O14561	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:Q8NG50	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:Q96MA6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:Q96N21	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:P02649	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CNTF	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0044877	protein-containing complex binding	CNTF	IPI	GO:0097058	Human	PMID:10966616
Molecular Function	GO:0044877	protein-containing complex binding	Cntf	IPI	RGD:1344115|RGD:1354198|RGD:731409	Rat	PMID:8385113|RGD:1626160
Cellular Component	GO:0030424	axon	Cntf	IDA		Rat	PMID:12849744|RGD:1358521
Cellular Component	GO:0005829	cytosol	Cntf	IDA		Rat	PMID:2594085|RGD:727240
Cellular Component	GO:0005615	extracellular space	Cntf	IDA		Mouse	PMID:15207851
Cellular Component	GO:0043025	neuronal cell body	Cntf	IDA		Rat	PMID:12849744|RGD:1358521
Cellular Component	GO:0005634	nucleus	Cntf	IDA		Rat	PMID:12849744|RGD:1358521
Cellular Component	GO:0032838	plasma membrane bounded cell projection cytoplasm	Cntf	IDA		Rat	PMID:12849744|RGD:1358521
Biological Process	GO:0048143	astrocyte activation	Cntf	IDA		Rat	PMID:11771938|RGD:1626172
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	CNTF	IDA		Human	PMID:12643274
Biological Process	GO:0060081	membrane hyperpolarization	Cntf	IDA		Rat	PMID:15831538|RGD:1626125
Biological Process	GO:0048644	muscle organ morphogenesis	Cntf	IGI	MGI:MGI:96787	Mouse	PMID:15716414
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	CNTF	IDA		Human	PMID:10966616
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Cntf	IDA		Rat	PMID:15574731|RGD:1626128
Biological Process	GO:1901215	negative regulation of neuron death	Cntf	IDA		Rat	PMID:14725620|RGD:1626115
Biological Process	GO:0046533	negative regulation of photoreceptor cell differentiation	Cntf	IDA		Mouse	PMID:15207851
Biological Process	GO:0007399	nervous system development	Cntf	IDA		Rat	PMID:11932952|RGD:727568
Biological Process	GO:0048666	neuron development	Cntf	IGI	MGI:MGI:96787	Mouse	PMID:15716414
Biological Process	GO:0048691	positive regulation of axon extension involved in regeneration	Cntf	IDA		Rat	PMID:16699509|RGD:12793002
Biological Process	GO:0048680	positive regulation of axon regeneration	Cntf	IDA		Rat	PMID:15574731|RGD:1626128
Biological Process	GO:0030307	positive regulation of cell growth	Cntf	IDA		Rat	PMID:11771938|RGD:1626172
Biological Process	GO:0008284	positive regulation of cell population proliferation	Cntf	IGI	MGI:MGI:95516	Mouse	PMID:15051883
Biological Process	GO:0008284	positive regulation of cell population proliferation	Cntf	IGI	MGI:MGI:95290	Mouse	PMID:15051883
Biological Process	GO:0008284	positive regulation of cell population proliferation	Cntf	IDA		Rat	PMID:15831538|RGD:1626125
Biological Process	GO:0010628	positive regulation of gene expression	CNTF	IDA		Human	PMID:24129709
Biological Process	GO:0046887	positive regulation of hormone secretion	Cntf	IDA		Rat	PMID:11771938|RGD:1626172
Biological Process	GO:0043410	positive regulation of MAPK cascade	Cntf	IDA		Rat	PMID:15574731|RGD:1626128
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Cntf	IDA		Rat	PMID:15574731|RGD:1626128
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Cntf	IDA		Rat	PMID:15574731|RGD:1626128
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	CNTF	IDA		Human	PMID:12643274
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	CNTF	IDA		Human	PMID:21912637
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Cntf	IDA		Mouse	PMID:15207851
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Cntf	IDA		Rat	PMID:14725620|RGD:1626115
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Cntf	IDA		Rat	PMID:15342787|RGD:1358676
Biological Process	GO:0060075	regulation of resting membrane potential	Cntf	IDA		Rat	PMID:15831538|RGD:1626125
Biological Process	GO:0046668	regulation of retinal cell programmed cell death	Cntf	IDA		Mouse	PMID:11747369
Biological Process	GO:0051602	response to electrical stimulus	Cntf	IEP		Rat	PMID:19576889|RGD:8655625
Biological Process	GO:0009642	response to light intensity	Cntf	IEP		Rat	PMID:21076359|RGD:8655612
Biological Process	GO:0060221	retinal rod cell differentiation	Cntf	IDA		Mouse	PMID:15207851
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	Cntf	IDA		Mouse	PMID:15207851

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern