Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes COL1A2
  • Mouse genes Col1a2
  • Rat genes Col1a2
  • Zfish genes col1a2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Col1a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength	COL1A2	HDA		Human	PMID:28344315
Molecular Function	GO:0042802	identical protein binding	COL1A2	IDA		Human	PMID:17211858
Molecular Function	GO:0048407	platelet-derived growth factor binding	COL1A2	IDA		Human	PMID:8900172
Molecular Function	GO:0002020	protease binding	COL1A2	IPI	UniProtKB:P39900	Human	PMID:19932771
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:P02452	Human	PMID:18375391
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:Q9UMX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:Q9UMX0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:P02452	Human	PMID:26848503
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:O43765	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:Q6PIL6	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:Q96EQ0	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:Q9UMX0-2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:O00303	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:Q14696	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:Q6PIL6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:Q96GM5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COL1A2	IPI	UniProtKB:Q9UMX0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Col1a2	IPI	UniPRotKB:P11087	Mouse	PMID:7629088
Molecular Function	GO:0005515	protein binding	Col1a2	IPI	PR:P11087	Mouse	PMID:9213002
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	COL1A2	IMP		Human	PMID:18375391
Molecular Function	GO:0046332	SMAD binding	Col1a2	IPI	PR:P97471	Mouse	PMID:14559231
Molecular Function	GO:0046332	SMAD binding	Col1a2	IPI	PR:Q8BUN5	Mouse	PMID:14559231
Molecular Function	GO:0046332	SMAD binding	Col1a2	IPI	PR:O35253	Mouse	PMID:14559231
Cellular Component	GO:0005581	collagen trimer	Col1a2	IDA		Mouse	PMID:8686743
Cellular Component	GO:0005581	collagen trimer	Col1a2	IDA		Mouse	PMID:17662583
Cellular Component	GO:0005581	collagen trimer	Col1a2	IDA		Mouse	PMID:10608859
Cellular Component	GO:0005584	collagen type I trimer	COL1A2	IPI		Human	PMID:26848503
Cellular Component	GO:0005584	collagen type I trimer	COL1A2	IMP		Human	PMID:17955022
Cellular Component	GO:0005584	collagen type I trimer	COL1A2	IDA		Human	PMID:18375391
Cellular Component	GO:0005584	collagen type I trimer	COL1A2	IDA		Human	PMID:19932771
Cellular Component	GO:0005584	collagen type I trimer	Col1a2	IDA		Mouse	PMID:7825727
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL1A2	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL1A2	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL1A2	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL1A2	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL1A2	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL1A2	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL1A2	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Col1a2	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Col1a2	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Col1a2	HDA		Mouse	MGI:MGI:5582867|PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Col1a2	IDA		Mouse	PMID:34368841
Cellular Component	GO:0070062	extracellular exosome	COL1A2	HDA		Human	PMID:21362503
Cellular Component	GO:0005576	extracellular region	COL1A2	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	COL1A2	IDA		Human	PMID:18375391
Cellular Component	GO:0005615	extracellular space	Col1a2	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Col1a2	IDA		Mouse	PMID:20053668
Biological Process	GO:0001568	blood vessel development	COL1A2	IMP		Human	PMID:17211858
Biological Process	GO:0030282	bone mineralization	Col1a2	IMP	MGI:MGI:1856327	Mouse	PMID:22910579
Biological Process	GO:0071230	cellular response to amino acid stimulus	Col1a2	IDA		Mouse	PMID:20548288
Biological Process	GO:0071310	cellular response to organic substance	Col1a2	IEP		Rat	PMID:11295527|RGD:7257541
Biological Process	GO:0071300	cellular response to retinoic acid	Col1a2	IEP		Rat	PMID:15234273|RGD:5688233
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	Col1a2	IEP		Rat	PMID:1381294|RGD:7257545
Biological Process	GO:0030199	collagen fibril organization	COL1A2	IMP		Human	PMID:17211858
Biological Process	GO:0030199	collagen fibril organization	COL1A2	IMP		Human	PMID:18375391
Biological Process	GO:0032963	collagen metabolic process	Col1a2	IMP	MGI:MGI:1856327	Mouse	PMID:22910579
Biological Process	GO:0085029	extracellular matrix assembly	Col1a2	IMP	MGI:MGI:1856327	Mouse	PMID:22910579
Biological Process	GO:0070208	protein heterotrimerization	Col1a2	IDA		Mouse	PMID:9213002
Biological Process	GO:0008217	regulation of blood pressure	COL1A2	IMP		Human	PMID:17334644
Biological Process	GO:0009612	response to mechanical stimulus	col1a2	IDA		Zfish	PMID:23632157
Biological Process	GO:0071873	response to norepinephrine	Col1a2	IEP		Rat	PMID:1951630|RGD:7257546
Biological Process	GO:0007266	Rho protein signal transduction	COL1A2	IDA		Human	PMID:17217948
Biological Process	GO:0001501	skeletal system development	COL1A2	IMP		Human	PMID:17955022
Biological Process	GO:0001501	skeletal system development	COL1A2	IMP		Human	PMID:18375391
Biological Process	GO:0001501	skeletal system development	COL1A2	IMP		Human	PMID:8841196
Biological Process	GO:0001501	skeletal system development	col1a2	IMP	ZFIN:ZDB-GENO-180503-8	Zfish	PMID:28835471
Biological Process	GO:0001501	skeletal system development	col1a2	IMP	ZFIN:ZDB-GENO-190325-11	Zfish	PMID:30082390
Biological Process	GO:0043589	skin morphogenesis	COL1A2	IMP		Human	PMID:17211858
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	COL1A2	IDA		Human	PMID:17217948

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern