Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes COL2A1
  • Mouse genes Col2a1
  • Rat genes Col2a1
  • Zfish genes col2a1a,col2a1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Col2a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength	COL2A1	HDA		Human	PMID:28344315
Molecular Function	GO:0042802	identical protein binding	Col2a1	IPI	UniProtKB:P28481	Mouse	MGI:MGI:5424105|PMID:22248926
Molecular Function	GO:0042289	MHC class II protein binding	COL2A1	IPI	UniProtKB:P01903,UniProtKB:P01911	Human	PMID:9354468
Molecular Function	GO:0048407	platelet-derived growth factor binding	COL2A1	IDA		Human	PMID:8900172
Molecular Function	GO:0043394	proteoglycan binding	COL2A1	IDA		Human	PMID:29030641
Cellular Component	GO:0005604	basement membrane	Col2a1	IDA		Mouse	PMID:11273670
Cellular Component	GO:0005581	collagen trimer	Col2a1	IDA		Mouse	PMID:17683922
Cellular Component	GO:0005581	collagen trimer	Col2a1	IDA		Mouse	PMID:20812917
Cellular Component	GO:0005585	collagen type II trimer	COL2A1	IDA		Human	PMID:8660302
Cellular Component	GO:0005585	collagen type II trimer	Col2a1	IDA		Mouse	PMID:9880238
Cellular Component	GO:0005585	collagen type II trimer	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:7276808
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL2A1	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL2A1	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL2A1	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL2A1	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL2A1	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Col2a1	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Col2a1	IDA		Rat	PMID:7649371|RGD:1298775
Cellular Component	GO:0005737	cytoplasm	Col2a1	IDA		Mouse	PMID:14614991
Cellular Component	GO:0005737	cytoplasm	Col2a1	IDA		Mouse	PMID:12799063
Cellular Component	GO:0005737	cytoplasm	Col2a1	IDA		Rat	PMID:23257135|RGD:8657411
Cellular Component	GO:0031012	extracellular matrix	Col2a1	IDA		Mouse	PMID:1879364
Cellular Component	GO:0031012	extracellular matrix	Col2a1	IDA		Mouse	PMID:23900597
Cellular Component	GO:0031012	extracellular matrix	Col2a1	IDA		Mouse	PMID:21624478
Cellular Component	GO:0031012	extracellular matrix	Col2a1	IDA		Mouse	PMID:16079159
Cellular Component	GO:0031012	extracellular matrix	Col2a1	IDA		Mouse	PMID:22206015
Cellular Component	GO:0031012	extracellular matrix	Col2a1	IDA		Mouse	PMID:9449075
Cellular Component	GO:0031012	extracellular matrix	Col2a1	IDA		Mouse	PMID:24191021
Cellular Component	GO:0005576	extracellular region	COL2A1	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	COL2A1	IMP		Human	PMID:20603131
Cellular Component	GO:0005615	extracellular space	Col2a1	IDA		Mouse	PMID:12799063
Cellular Component	GO:0005615	extracellular space	Col2a1	IDA		Mouse	PMID:14614991
Biological Process	GO:0097065	anterior head development	Col2a1	IMP	MGI:MGI:4999626	Mouse	PMID:26234751
Biological Process	GO:0097065	anterior head development	Col2a1	IMP	MGI:MGI:5551861	Mouse	PMID:26234751
Biological Process	GO:0007411	axon guidance	col2a1a	IMP	ZFIN:ZDB-GENO-980202-988	Zfish	PMID:27339293
Biological Process	GO:0060348	bone development	Col2a1	IMP	MGI:MGI:2148858	Mouse	PMID:11254354
Biological Process	GO:0001502	cartilage condensation	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:3070812
Biological Process	GO:0051216	cartilage development	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:7590256
Biological Process	GO:0051216	cartilage development	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:11171689
Biological Process	GO:0051216	cartilage development	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:9832566
Biological Process	GO:0051216	cartilage development	Col2a1	IMP		Mouse	PMID:9061443
Biological Process	GO:0051216	cartilage development	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:11680679
Biological Process	GO:0051216	cartilage development	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:9165353
Biological Process	GO:0051216	cartilage development	Col2a1	IMP		Mouse	PMID:10100048
Biological Process	GO:0051216	cartilage development	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:7276808
Biological Process	GO:0051216	cartilage development	Col2a1	IEP		Rat	PMID:9822201|RGD:70694
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:8989518
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	Col2a1	IMP		Mouse	PMID:9022054
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:11680679
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	Col2a1	IEP		Rat	PMID:12924823|RGD:8661659
Biological Process	GO:0071773	cellular response to BMP stimulus	Col2a1	IDA		Mouse	PMID:20501701
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	Col2a1	IEP		Rat	PMID:18595745|RGD:11667101
Biological Process	GO:0071260	cellular response to mechanical stimulus	Col2a1	IEP		Rat	PMID:19725071|RGD:8661239
Biological Process	GO:0071316	cellular response to nicotine	Col2a1	IEP		Rat	PMID:22766705|RGD:8661258
Biological Process	GO:0071374	cellular response to parathyroid hormone stimulus	Col2a1	IEP		Rat	PMID:22750004|RGD:8661244
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Col2a1	IEP		Rat	PMID:11120880|RGD:8661236
Biological Process	GO:0071300	cellular response to retinoic acid	Col2a1	IEP		Rat	PMID:23810783|RGD:8661241
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Col2a1	IEP		Rat	PMID:19144181|RGD:8661243
Biological Process	GO:0071306	cellular response to vitamin E	Col2a1	IEP		Rat	PMID:23722449|RGD:8552711
Biological Process	GO:0007417	central nervous system development	Col2a1	IEP		Mouse	MGI:MGI:86312|PMID:9119111
Biological Process	GO:0002062	chondrocyte differentiation	Col2a1	IEP		Mouse	MGI:MGI:86312|PMID:9119111
Biological Process	GO:0002062	chondrocyte differentiation	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:11680679
Biological Process	GO:0002062	chondrocyte differentiation	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:7590256
Biological Process	GO:0002062	chondrocyte differentiation	Col2a1	IEP		Rat	PMID:21627568|RGD:5134342
Biological Process	GO:0030199	collagen fibril organization	COL2A1	IMP		Human	PMID:1429602
Biological Process	GO:0030199	collagen fibril organization	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:9915573
Biological Process	GO:0030199	collagen fibril organization	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:11171689
Biological Process	GO:0030199	collagen fibril organization	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:3070812
Biological Process	GO:0030199	collagen fibril organization	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:7590256
Biological Process	GO:0030199	collagen fibril organization	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:7276808
Biological Process	GO:0030199	collagen fibril organization	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:9832566
Biological Process	GO:0030199	collagen fibril organization	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:8989518
Biological Process	GO:0030199	collagen fibril organization	Col2a1	IMP		Mouse	PMID:9022054
Biological Process	GO:0060272	embryonic skeletal joint morphogenesis	COL2A1	IMP		Human	PMID:16752401
Biological Process	GO:0048706	embryonic skeletal system development	col2a1a	IMP	ZFIN:ZDB-GENO-180503-9	Zfish	PMID:28835471
Biological Process	GO:0048706	embryonic skeletal system development	col2a1a	IMP	ZFIN:ZDB-GENO-180503-13	Zfish	PMID:28835471
Biological Process	GO:0001958	endochondral ossification	Col2a1	IMP		Mouse	PMID:10100048
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:9299161
Biological Process	GO:0033333	fin development	col2a1b	IMP	ZFIN:ZDB-MRPHLNO-110630-3	Zfish	PMID:21420398
Biological Process	GO:0033334	fin morphogenesis	col2a1b	IMP	ZFIN:ZDB-MRPHLNO-110630-3	Zfish	PMID:21420398
Biological Process	GO:0003417	growth plate cartilage development	Col2a1	IEP		Rat	PMID:20591638|RGD:8661256
Biological Process	GO:0003007	heart morphogenesis	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:7590256
Biological Process	GO:0048839	inner ear development	Col2a1	IMP		Mouse	PMID:10100048
Biological Process	GO:0042472	inner ear morphogenesis	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:9165353
Biological Process	GO:0060174	limb bud formation	Col2a1	IEP		Mouse	MGI:MGI:5285147|PMID:20940257
Biological Process	GO:0035108	limb morphogenesis	Col2a1	IMP		Mouse	PMID:10100048
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:9299161
Biological Process	GO:0030903	notochord development	Col2a1	IEP		Mouse	MGI:MGI:86312|PMID:9119111
Biological Process	GO:0030903	notochord development	col2a1a	IGI	ZFIN:ZDB-MRPHLNO-070818-2,ZFIN:ZDB-MRPHLNO-070919-6	Zfish	PMID:17543297
Biological Process	GO:0030903	notochord development	col2a1a	IGI	ZFIN:ZDB-MRPHLNO-070818-1,ZFIN:ZDB-MRPHLNO-070919-6	Zfish	PMID:17543297
Biological Process	GO:0030903	notochord development	col2a1a	IGI	ZFIN:ZDB-MRPHLNO-070919-4,ZFIN:ZDB-MRPHLNO-070919-6	Zfish	PMID:17543297
Biological Process	GO:0001503	ossification	Col2a1	IEP		Mouse	MGI:MGI:86312|PMID:9119111
Biological Process	GO:0071599	otic vesicle development	Col2a1	IEP		Mouse	MGI:MGI:86312|PMID:9119111
Biological Process	GO:0006029	proteoglycan metabolic process	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:7276808
Biological Process	GO:0006029	proteoglycan metabolic process	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:3070812
Biological Process	GO:0010468	regulation of gene expression	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:9299161
Biological Process	GO:0071774	response to fibroblast growth factor	Col2a1	IEP		Rat	PMID:21147086|RGD:8661238
Biological Process	GO:0009612	response to mechanical stimulus	Col2a1	IEP		Rat	PMID:19242967|RGD:8661245
Biological Process	GO:0010165	response to X-ray	Col2a1	IEP		Rat	PMID:17549535|RGD:8661655
Biological Process	GO:0060021	roof of mouth development	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:7276808
Biological Process	GO:0007605	sensory perception of sound	COL2A1	IMP		Human	PMID:16752401
Biological Process	GO:0001501	skeletal system development	COL2A1	IMP		Human	PMID:1429602
Biological Process	GO:0048705	skeletal system morphogenesis	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:8192242
Biological Process	GO:0048705	skeletal system morphogenesis	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:9915573
Biological Process	GO:0048705	skeletal system morphogenesis	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:7590256
Biological Process	GO:0048705	skeletal system morphogenesis	Col2a1	IMP	MGI:MGI:1857275	Mouse	PMID:7276808
Biological Process	GO:0001894	tissue homeostasis	Col2a1	IMP	MGI:MGI:2152978	Mouse	PMID:11237662
Biological Process	GO:0007601	visual perception	COL2A1	IMP		Human	PMID:10486316
Biological Process	GO:0007601	visual perception	COL2A1	IMP		Human	PMID:16752401

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern