Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes COL4A3
  • Mouse genes Col4a3
  • Rat genes Col4a3
  • Zfish genes col4a3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Col4a3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength	COL4A3	HDA		Human	PMID:28344315
Molecular Function	GO:0005178	integrin binding	COL4A3	IDA		Human	PMID:12682293
Molecular Function	GO:0005515	protein binding	COL4A3	IPI	UniProtKB:Q9Y5P4	Human	PMID:10212244
Molecular Function	GO:0005515	protein binding	COL4A3	IPI	UniProtKB:P05106	Human	PMID:12682293
Cellular Component	GO:0005604	basement membrane	COL4A3	IDA		Human	PMID:10766752
Cellular Component	GO:0005604	basement membrane	Col4a3	IDA		Mouse	MGI:MGI:3776221|PMID:16041630
Cellular Component	GO:0005604	basement membrane	Col4a3	IDA		Mouse	PMID:18757743
Cellular Component	GO:0005604	basement membrane	Col4a3	IDA		Mouse	PMID:11732842
Cellular Component	GO:0005587	collagen type IV trimer	COL4A3	IDA		Human	PMID:10766752
Cellular Component	GO:0005587	collagen type IV trimer	Col4a3	IDA		Mouse	PMID:12101409
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL4A3	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL4A3	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL4A3	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Col4a3	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005783	endoplasmic reticulum	COL4A3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	COL4A3	IDA		Human	GO_REF:0000052
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	COL4A3	IDA		Human	PMID:10766752
Biological Process	GO:0007166	cell surface receptor signaling pathway	Col4a3	IDA		Mouse	MGI:MGI:3706464|PMID:12842087
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	Col4a3	IGI	MGI:MGI:88456	Mouse	PMID:10970885
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	Col4a3	IGI	MGI:MGI:88467	Mouse	PMID:10970885
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	Col4a3	IGI	MGI:MGI:88455	Mouse	PMID:10970885
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	Col4a3	IGI	MGI:MGI:2152695	Mouse	PMID:10970885
Biological Process	GO:0072577	endothelial cell apoptotic process	COL4A3	IDA		Human	PMID:10766752
Biological Process	GO:0032836	glomerular basement membrane development	Col4a3	IMP		Mouse	MGI:MGI:3610934|PMID:12631063
Biological Process	GO:0016525	negative regulation of angiogenesis	COL4A3	IDA		Human	PMID:10766752
Biological Process	GO:0016525	negative regulation of angiogenesis	COL4A3	IDA		Human	PMID:12682293
Biological Process	GO:0016525	negative regulation of angiogenesis	Col4a3	IDA		Mouse	MGI:MGI:3706481|PMID:16877525
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	COL4A3	IDA		Human	PMID:10766752
Biological Process	GO:0009749	response to glucose	Col4a3	IEP		Rat	PMID:12150963|RGD:1600926

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern