Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes COMMD1
  • Mouse genes Commd1
  • Rat genes Commd1
  • Zfish genes commd1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Commd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005507	copper ion binding	COMMD1	IDA		Human	PMID:17309234
Molecular Function	GO:0042802	identical protein binding	COMMD1	IPI	UniProtKB:Q8N668	Human	PMID:15799966
Molecular Function	GO:0070300	phosphatidic acid binding	COMMD1	IDA		Human	PMID:18940794
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	COMMD1	IDA		Human	PMID:18940794
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	COMMD1	IDA		Human	PMID:18940794
Molecular Function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	COMMD1	IDA		Human	PMID:18940794
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	COMMD1	IDA		Human	PMID:18940794
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:P35670	Human	PMID:12968035
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:P51172	Human	PMID:14645214
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:P25963	Human	PMID:14685242
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q04206	Human	PMID:14685242
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:P98170	Human	PMID:14685266
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q01201	Human	PMID:15799966
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q04206	Human	PMID:15799966
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q04864	Human	PMID:15799966
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q7Z4G1	Human	PMID:15799966
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q86VX2	Human	PMID:15799966
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q86X83	Human	PMID:15799966
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9GZQ3	Human	PMID:15799966
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9H0A8	Human	PMID:15799966
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9NX08	Human	PMID:15799966
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9UBI1	Human	PMID:15799966
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9Y6G5	Human	PMID:15799966
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:O15524	Human	PMID:17183367
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q04206	Human	PMID:17183367
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q13617	Human	PMID:17183367
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q15369	Human	PMID:17183367
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:P35670	Human	PMID:17919502
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q8N726	Human	PMID:18305112
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:O00141	Human	PMID:20237237
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:P31749	Human	PMID:20237237
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:P51168	Human	PMID:20237237
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q04656	Human	PMID:21667063
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q13616	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q13617	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q13618	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q13619	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q13620	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q14999	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q93034	Human	PMID:21778237
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:O60826	Human	PMID:23563313
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q13617	Human	PMID:23563313
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q15369	Human	PMID:23563313
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q7Z4G1	Human	PMID:23563313
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9H0A8	Human	PMID:23563313
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9NX08	Human	PMID:23563313
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9UBI1	Human	PMID:23563313
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:O60826	Human	PMID:25355947
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q567U6	Human	PMID:25355947
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q7Z4G1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:O60826	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q567U6	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:O60826	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q567U6	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q86X83	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9GZQ3	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9H0A8	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9NX08	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9UBI1	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9Y6G5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:O95990	Human	PMID:28604741
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:O60826	Human	PMID:28892079
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:O60826	Human	PMID:29778605
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q9UBI1	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:P26583	Human	PMID:31694235
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q7Z4G1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q8IYN2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:Q96BW1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMMD1	IPI	UniProtKB:P26583	Human	PMID:32867128
Molecular Function	GO:0005515	protein binding	Commd1	IPI	PR:Q61221	Mouse	PMID:17371845
Molecular Function	GO:0042803	protein homodimerization activity	COMMD1	IPI	UniProtKB:Q8N668	Human	PMID:15799966
Molecular Function	GO:0042803	protein homodimerization activity	COMMD1	IPI	UniProtKB:Q8N668	Human	PMID:17309234
Molecular Function	GO:0019871	sodium channel inhibitor activity	COMMD1	IDA		Human	PMID:14645214
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	COMMD1	IDA		Human	PMID:17183367
Cellular Component	GO:0005737	cytoplasm	COMMD1	IDA		Human	PMID:14685266
Cellular Component	GO:0005829	cytosol	COMMD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005769	early endosome	COMMD1	IDA		Human	PMID:25355947
Cellular Component	GO:0005768	endosome	Commd1	IDA		Mouse	PMID:26965651
Cellular Component	GO:0005654	nucleoplasm	COMMD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	COMMD1	IDA		Human	PMID:15799966
Cellular Component	GO:0055037	recycling endosome	COMMD1	IDA		Human	PMID:21741370
Biological Process	GO:0042632	cholesterol homeostasis	Commd1	IMP	MGI:MGI:2176228,MGI:MGI:5315712	Mouse	PMID:26965651
Biological Process	GO:0055070	copper ion homeostasis	COMMD1	IDA		Human	PMID:14685266
Biological Process	GO:0006893	Golgi to plasma membrane transport	COMMD1	IMP		Human	PMID:25355947
Biological Process	GO:0034383	low-density lipoprotein particle clearance	Commd1	IMP	MGI:MGI:2176228,MGI:MGI:5315712	Mouse	PMID:26965651
Biological Process	GO:1902072	negative regulation of hypoxia-inducible factor-1alpha signaling pathway	Commd1	IMP	MGI:MGI:3714157	Mouse	PMID:17371845
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	COMMD1	IDA		Human	PMID:16573520
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	COMMD1	IDA		Human	PMID:15799966
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	COMMD1	IMP		Human	PMID:17183367
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	COMMD1	IDA		Human	PMID:21741370
Biological Process	GO:1902306	negative regulation of sodium ion transmembrane transport	COMMD1	IDA		Human	PMID:14645214
Biological Process	GO:1902306	negative regulation of sodium ion transmembrane transport	COMMD1	IMP		Human	PMID:20237237
Biological Process	GO:0006289	nucleotide-excision repair	COMMD1	IMP		Human	PMID:23144634
Biological Process	GO:0048227	plasma membrane to endosome transport	COMMD1	IDA		Human	PMID:21741370
Biological Process	GO:1904109	positive regulation of cholesterol import	Commd1	IMP	MGI:MGI:2176228,MGI:MGI:5315712	Mouse	PMID:26965651
Biological Process	GO:1905751	positive regulation of endosome to plasma membrane protein transport	Commd1	IMP	MGI:MGI:2176228,MGI:MGI:5315712	Mouse	PMID:26965651
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	Commd1	IMP	MGI:MGI:2176228,MGI:MGI:5315712	Mouse	PMID:26965651
Biological Process	GO:0031398	positive regulation of protein ubiquitination	COMMD1	IDA		Human	PMID:17183367
Biological Process	GO:0031398	positive regulation of protein ubiquitination	COMMD1	IDA		Human	PMID:21741370
Biological Process	GO:0031648	protein destabilization	Commd1	IMP	MGI:MGI:3714157	Mouse	PMID:17371845
Biological Process	GO:0034394	protein localization to cell surface	Commd1	IMP	MGI:MGI:2176228,MGI:MGI:5315712	Mouse	PMID:26965651
Biological Process	GO:0097006	regulation of plasma lipoprotein particle levels	Commd1	IMP	MGI:MGI:2176228,MGI:MGI:5315712	Mouse	PMID:26965651
Biological Process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	COMMD1	IMP		Human	PMID:17183367

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern