Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes COMP
  • Mouse genes Comp
  • Rat genes Comp
  • Zfish genes comp
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Comp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0036122	BMP binding	Comp	IPI	PR:P21274	Mouse	PMID:21350216
Molecular Function	GO:0005509	calcium ion binding	COMP	IDA		Human	PMID:10852928
Molecular Function	GO:0005509	calcium ion binding	COMP	IDA		Human	PMID:11084047
Molecular Function	GO:0005518	collagen binding	COMP	IDA		Human	PMID:11084047
Molecular Function	GO:0005201	extracellular matrix structural constituent	Comp	IDA		Rat	PMID:12225811|RGD:1298778
Molecular Function	GO:0001968	fibronectin binding	Comp	IDA		Rat	PMID:12225811|RGD:1298778
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	COMP	IDA		Human	PMID:17588949
Molecular Function	GO:0008201	heparin binding	COMP	IDA		Human	PMID:17588949
Molecular Function	GO:0005178	integrin binding	Comp	IPI	PR:O54890	Mouse	PMID:27151399
Molecular Function	GO:0002020	protease binding	COMP	IPI	UniProtKB:P58397	Human	PMID:18485748
Molecular Function	GO:0002020	protease binding	COMP	IPI	UniProtKB:Q9UKP4	Human	PMID:18485748
Molecular Function	GO:0002020	protease binding	Comp	IPI	UniProtKB:P58397	Mouse	MGI:MGI:5532918|PMID:16611630
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P02751	Human	PMID:12225811
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:O15232	Human	PMID:15075323
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:O95460	Human	PMID:15075323
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P21941	Human	PMID:15075323
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P05106	Human	PMID:16051604
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P08648	Human	PMID:16051604
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P58397	Human	PMID:16611630
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P13608	Human	PMID:17588949
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P16112	Human	PMID:17588949
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P58397	Human	PMID:18485748
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P32242	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P32242	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:O00244	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P29972	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:P32242	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:Q7Z417	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMP	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Comp	IPI	UniProtKB:P58397	Mouse	MGI:MGI:5532918|PMID:16611630
Molecular Function	GO:0005515	protein binding	Comp	IPI	PR:Q61508	Mouse	PMID:20138147
Molecular Function	GO:0005515	protein binding	Comp	IPI	PR:P28798	Mouse	PMID:17307734
Molecular Function	GO:0005515	protein binding	Comp	IPI	UniProtKB:Q63258	Rat	PMID:20019333|RGD:8554850
Molecular Function	GO:0043394	proteoglycan binding	COMP	IDA		Human	PMID:29030641
Molecular Function	GO:0005499	vitamin D binding	Comp	IMP		Rat	PMID:12426368|RGD:1298777
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COMP	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Comp	IDA		Rat	PMID:16778685|RGD:1600712
Cellular Component	GO:0070062	extracellular exosome	COMP	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	COMP	HDA		Human	PMID:27068509
Cellular Component	GO:0005576	extracellular region	COMP	IDA		Human	PMID:32747625
Cellular Component	GO:0005576	extracellular region	Comp	IDA		Mouse	MGI:MGI:6828896|PMID:32747625
Cellular Component	GO:0005615	extracellular space	COMP	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	Comp	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Comp	IDA		Mouse	PMID:17588960
Cellular Component	GO:0005615	extracellular space	Comp	IDA		Mouse	PMID:26746240
Cellular Component	GO:0032991	protein-containing complex	Comp	IDA		Mouse	PMID:26045608
Biological Process	GO:0006915	apoptotic process	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:17588960
Biological Process	GO:0048844	artery morphogenesis	Comp	IMP		Mouse	PMID:27151399
Biological Process	GO:0007596	blood coagulation	Comp	IMP	MGI:MGI:2180787	Mouse	PMID:26045608
Biological Process	GO:0030509	BMP signaling pathway	Comp	IMP		Mouse	PMID:21350216
Biological Process	GO:0098868	bone growth	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:17588960
Biological Process	GO:0030282	bone mineralization	Comp	IMP		Mouse	PMID:27151399
Biological Process	GO:0060349	bone morphogenesis	Comp	IGI	MGI:MGI:88465	Mouse	PMID:18191556
Biological Process	GO:0051216	cartilage development	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:17588960
Biological Process	GO:0051216	cartilage development	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:23951406
Biological Process	GO:0051216	cartilage development	Comp	IGI	MGI:MGI:88465	Mouse	PMID:18191556
Biological Process	GO:0051216	cartilage development	Comp	IMP	MGI:MGI:5550566	Mouse	PMID:23951406
Biological Process	GO:1990079	cartilage homeostasis	COMP	IDA		Human	PMID:32747625
Biological Process	GO:1990079	cartilage homeostasis	Comp	IDA		Mouse	MGI:MGI:6828896|PMID:32747625
Biological Process	GO:0090398	cellular senescence	Comp	IMP	MGI:MGI:2180787	Mouse	PMID:27498005
Biological Process	GO:0002063	chondrocyte development	Comp	IMP	MGI:MGI:5550566	Mouse	PMID:22006726
Biological Process	GO:0002063	chondrocyte development	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:17588960
Biological Process	GO:0035988	chondrocyte proliferation	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:17588960
Biological Process	GO:0035988	chondrocyte proliferation	Comp	IMP	MGI:MGI:5550566	Mouse	PMID:22006726
Biological Process	GO:0035988	chondrocyte proliferation	Comp	IGI	MGI:MGI:88465	Mouse	PMID:18191556
Biological Process	GO:0030199	collagen fibril organization	Comp	IMP		Mouse	PMID:19808781
Biological Process	GO:0030199	collagen fibril organization	Comp	IMP	MGI:MGI:2180787	Mouse	PMID:26746240
Biological Process	GO:0030199	collagen fibril organization	Comp	IMP	MGI:MGI:5550566	Mouse	PMID:24312420
Biological Process	GO:0003416	endochondral bone growth	Comp	IMP		Mouse	PMID:20138147
Biological Process	GO:0003417	growth plate cartilage development	Comp	IGI	MGI:MGI:88465	Mouse	PMID:18191556
Biological Process	GO:0003417	growth plate cartilage development	Comp	IMP	MGI:MGI:2180787	Mouse	PMID:18467703
Biological Process	GO:0003417	growth plate cartilage development	Comp	IGI	MGI:MGI:98737	Mouse	PMID:18467703
Biological Process	GO:0003417	growth plate cartilage development	Comp	IGI	MGI:MGI:88465	Mouse	PMID:18467703
Biological Process	GO:0003417	growth plate cartilage development	Comp	IGI	MGI:MGI:98739	Mouse	PMID:18467703
Biological Process	GO:0003417	growth plate cartilage development	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:17588960
Biological Process	GO:0060173	limb development	COMP	IDA		Human	PMID:16542502
Biological Process	GO:0060173	limb development	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:17588960
Biological Process	GO:0060173	limb development	Comp	IMP	MGI:MGI:5550566	Mouse	PMID:22006726
Biological Process	GO:0035264	multicellular organism growth	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:17588960
Biological Process	GO:0035264	multicellular organism growth	Comp	IMP	MGI:MGI:5550566	Mouse	PMID:22006726
Biological Process	GO:0055001	muscle cell development	Comp	IMP	MGI:MGI:5550566	Mouse	PMID:24312420
Biological Process	GO:0055001	muscle cell development	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:19808781
Biological Process	GO:0050881	musculoskeletal movement	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:19808781
Biological Process	GO:0043066	negative regulation of apoptotic process	COMP	IDA		Human	PMID:17993464
Biological Process	GO:1900047	negative regulation of hemostasis	Comp	IMP	MGI:MGI:2180787	Mouse	PMID:26045608
Biological Process	GO:0050905	neuromuscular process	Comp	IMP	MGI:MGI:5550566	Mouse	PMID:24312420
Biological Process	GO:0001503	ossification	Comp	IMP		Mouse	PMID:27151399
Biological Process	GO:0001503	ossification	Comp	IMP		Mouse	PMID:21350216
Biological Process	GO:0070527	platelet aggregation	Comp	IMP	MGI:MGI:2180787	Mouse	PMID:26045608
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	Comp	IMP		Mouse	PMID:17307734
Biological Process	GO:0051260	protein homooligomerization	COMP	IDA		Human	PMID:32747625
Biological Process	GO:0051260	protein homooligomerization	Comp	IDA		Mouse	MGI:MGI:6828896|PMID:32747625
Biological Process	GO:0016485	protein processing	Comp	IMP	MGI:MGI:2180787	Mouse	PMID:26045608
Biological Process	GO:0009306	protein secretion	Comp	IMP	MGI:MGI:2180787	Mouse	PMID:26746240
Biological Process	GO:0030500	regulation of bone mineralization	Comp	IMP		Mouse	PMID:21350216
Biological Process	GO:0010468	regulation of gene expression	Comp	IMP	MGI:MGI:5550566	Mouse	PMID:22006726
Biological Process	GO:0010468	regulation of gene expression	Comp	IMP	MGI:MGI:2180787	Mouse	PMID:27498005
Biological Process	GO:0006986	response to unfolded protein	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:17588960
Biological Process	GO:0001501	skeletal system development	Comp	IGI	MGI:MGI:88465	Mouse	PMID:18191556
Biological Process	GO:0043588	skin development	Comp	IMP	MGI:MGI:2180787	Mouse	PMID:26746240
Biological Process	GO:0035989	tendon development	Comp	IMP	MGI:MGI:5550566	Mouse	PMID:24312420
Biological Process	GO:0035989	tendon development	Comp	IMP	MGI:MGI:3758741	Mouse	PMID:19808781
Biological Process	GO:0097084	vascular associated smooth muscle cell development	Comp	IMP		Mouse	PMID:21350216
Biological Process	GO:0014829	vascular associated smooth muscle contraction	Comp	IMP	MGI:MGI:2180787	Mouse	PMID:27498005

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern