Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes COMT
  • Mouse genes Comt
  • Rat genes Comt
  • Zfish genes comta,comtb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Comt

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016206	catechol O-methyltransferase activity	COMT	IDA		Human	PMID:11559542
Molecular Function	GO:0016206	catechol O-methyltransferase activity	COMT	IDA		Human	PMID:15645182
Molecular Function	GO:0016206	catechol O-methyltransferase activity	COMT	IDA		Human	PMID:21846718
Molecular Function	GO:0016206	catechol O-methyltransferase activity	Comt	IDA		Mouse	PMID:20374420
Molecular Function	GO:0016206	catechol O-methyltransferase activity	Comt	IDA		Rat	PMID:12584150|RGD:1359089
Molecular Function	GO:0016206	catechol O-methyltransferase activity	comta	IDA		Zfish	PMID:21371608
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q15645	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q15645	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:A0PK00	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:A6NDP7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:B2RUZ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:O00258	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:O14843	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:O15529	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:O60669	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:O75712	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:O75783	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:O95183	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:O95279	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:O95377	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:O95807	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:P08034	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:P22732	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:P30518	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:P30825	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:P31937	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:P34972	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:P34981	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:P50402	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q0D2K0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q14656	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q15836	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q3KNW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q5SR56	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q5T1Q4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q6NTF9-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q6P1K1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q6P5T0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q6UW68	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q7RTS5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q8IY26	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q8N6U8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q8NFU1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q8NHW4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q96BA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q96G79	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q96MV1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q99500	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9H0R3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9H2F3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9H6H4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9NP94	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9NTQ9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9NV29	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9NY26	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9P0S9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9UHI5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9UHJ9-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9UPZ6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:Q9Y6D0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	COMT	IPI	UniProtKB:O76024	Human	PMID:32814053
Cellular Component	GO:0030424	axon	Comt	IDA		Rat	PMID:21846718|RGD:8662337
Cellular Component	GO:0044297	cell body	Comt	IDA		Rat	PMID:21846718|RGD:8662337
Cellular Component	GO:0005829	cytosol	Comt	IDA		Rat	PMID:10410961|RGD:8662338
Cellular Component	GO:0030425	dendrite	Comt	IDA		Rat	PMID:21846718|RGD:8662337
Cellular Component	GO:0043197	dendritic spine	Comt	IDA		Rat	PMID:7617303|RGD:8662339
Cellular Component	GO:0070062	extracellular exosome	COMT	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	COMT	HDA		Human	PMID:23533145
Cellular Component	GO:0098978	glutamatergic synapse	Comt	IDA		Rat	PMID:7617303|RGD:8662339
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	COMT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	COMT	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Comt	IDA		Rat	PMID:14714585|RGD:2289787
Cellular Component	GO:0005739	mitochondrion	Comt	HDA		Mouse	PMID:18614015
Cellular Component	GO:0098794	postsynapse	Comt	IDA		Rat	PMID:7617303|RGD:8662339
Cellular Component	GO:0045211	postsynaptic membrane	Comt	IDA		Rat	PMID:7617303|RGD:8662339
Biological Process	GO:0042424	catecholamine catabolic process	COMT	IDA		Human	PMID:11559542
Biological Process	GO:0042424	catecholamine catabolic process	COMT	IDA		Human	PMID:15645182
Biological Process	GO:0042424	catecholamine catabolic process	COMT	IDA		Human	PMID:21846718
Biological Process	GO:0016036	cellular response to phosphate starvation	Comt	IDA		Mouse	PMID:23863468
Biological Process	GO:0032502	developmental process	Comt	IEP		Rat	PMID:438804|RGD:8662345
Biological Process	GO:0042420	dopamine catabolic process	Comt	IDA		Mouse	PMID:9520487
Biological Process	GO:0042417	dopamine metabolic process	Comt	IDA		Mouse	PMID:23863468
Biological Process	GO:0008210	estrogen metabolic process	Comt	IMP		Rat	PMID:11071850|RGD:2289790
Biological Process	GO:0007565	female pregnancy	Comt	IMP		Rat	PMID:18042640|RGD:2289727
Biological Process	GO:0007612	learning	Comt	IMP		Rat	PMID:15190105|RGD:2289786
Biological Process	GO:0032259	methylation	COMT	IDA		Human	PMID:11559542
Biological Process	GO:0048609	multicellular organismal reproductive process	Comt	IMP		Rat	PMID:17699737|RGD:2289731
Biological Process	GO:0045963	negative regulation of dopamine metabolic process	Comt	IMP		Rat	PMID:15190105|RGD:2289786
Biological Process	GO:0035814	negative regulation of renal sodium excretion	Comt	IMP		Rat	PMID:10450019|RGD:8662342
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Comt	IMP		Rat	PMID:11071850|RGD:2289790
Biological Process	GO:0042135	neurotransmitter catabolic process	Comt	IDA		Mouse	PMID:20626558
Biological Process	GO:0042135	neurotransmitter catabolic process	Comt	IMP		Mouse	PMID:20626558
Biological Process	GO:0050668	positive regulation of homocysteine metabolic process	Comt	IMP		Rat	PMID:15779086|RGD:2289784
Biological Process	GO:0051930	regulation of sensory perception of pain	Comt	IMP		Rat	PMID:20219633|RGD:8662340
Biological Process	GO:0043627	response to estrogen	Comt	IEP		Rat	PMID:22100850|RGD:13451127
Biological Process	GO:0032496	response to lipopolysaccharide	Comt	IEP		Rat	PMID:17573159|RGD:2289732
Biological Process	GO:0014070	response to organic cyclic compound	Comt	IEP		Rat	PMID:15964593|RGD:2289783
Biological Process	GO:0048265	response to pain	Comt	IMP		Rat	PMID:17084978|RGD:2289747
Biological Process	GO:0009410	response to xenobiotic stimulus	Comt	IEP		Rat	PMID:17868501|RGD:2289730
Biological Process	GO:0007614	short-term memory	Comt	IMP		Rat	PMID:22815336|RGD:8662341

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern