Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CR1,CR1L
  • Mouse genes Cr1l
  • Rat genes Cr1l
  • Zfish genes rca2.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cr1l

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001851	complement component C3b binding	CR1	IDA		Human	PMID:2972794
Molecular Function	GO:0004877	complement component C3b receptor activity	CR1	IDA		Human	PMID:2972794
Molecular Function	GO:0001855	complement component C4b binding	CR1	IDA		Human	PMID:2972794
Molecular Function	GO:0001861	complement component C4b receptor activity	CR1	IDA		Human	PMID:2972794
Molecular Function	GO:0005515	protein binding	CR1	IPI	UniProtKB:Q12923	Human	PMID:18684861
Molecular Function	GO:0005515	protein binding	CR1	IPI	UniProtKB:O75636	Human	PMID:23460739
Molecular Function	GO:0005515	protein binding	CR1	IPI	UniProtKB:P11226	Human	PMID:23460739
Molecular Function	GO:0005515	protein binding	CR1	IPI	UniProtKB:Q15485	Human	PMID:23460739
Molecular Function	GO:0005515	protein binding	CR1	IPI	UniProtKB:P11226	Human	PMID:29563915
Molecular Function	GO:0005515	protein binding	CR1L	IPI	UniProtKB:Q8NEL9-2	Human	PMID:32296183
Cellular Component	GO:0016323	basolateral plasma membrane	Cr1l	IDA		Mouse	PMID:20675597
Cellular Component	GO:0009986	cell surface	CR1	IDA		Human	PMID:2972794
Cellular Component	GO:0009986	cell surface	CR1	IDA		Human	PMID:6978375
Cellular Component	GO:0009986	cell surface	CR1	IDA		Human	PMID:25742728
Cellular Component	GO:0009986	cell surface	Cr1l	IDA		Mouse	PMID:20675597
Cellular Component	GO:0005856	cytoskeleton	CR1	IDA		Human	PMID:18684861
Cellular Component	GO:0009897	external side of plasma membrane	Cr1l	IDA		Mouse	PMID:18947875
Cellular Component	GO:0070062	extracellular exosome	CR1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CR1	HDA		Human	PMID:23533145
Cellular Component	GO:0005886	plasma membrane	CR1	IDA		Human	PMID:6910481
Cellular Component	GO:0044853	plasma membrane raft	CR1	IDA		Human	PMID:24022490
Cellular Component	GO:0043235	receptor complex	CR1L	IDA		Human	PMID:23382219
Biological Process	GO:1904669	ATP export	CR1	IDA		Human	PMID:24022490
Biological Process	GO:0071456	cellular response to hypoxia	Cr1l	IDA		Mouse	PMID:20675597
Biological Process	GO:0006956	complement activation	Cr1l	IMP		Mouse	PMID:20675597
Biological Process	GO:0006957	complement activation, alternative pathway	CR1	IMP		Human	PMID:11981823
Biological Process	GO:0002430	complement receptor mediated signaling pathway	CR1	IDA		Human	PMID:16360013
Biological Process	GO:0002430	complement receptor mediated signaling pathway	CR1	IDA		Human	PMID:22962438
Biological Process	GO:0002435	immune complex clearance by erythrocytes	CR1	IDA		Human	PMID:24022490
Biological Process	GO:0001701	in utero embryonic development	Cr1l	IGI	MGI:MGI:88233	Mouse	PMID:18947875
Biological Process	GO:0001971	negative regulation of activation of membrane attack complex	CR1	IDA		Human	PMID:31862673
Biological Process	GO:0045916	negative regulation of complement activation	CR1	IDA		Human	PMID:31862673
Biological Process	GO:0045916	negative regulation of complement activation	Cr1l	IMP	MGI:MGI:2158683	Mouse	PMID:10642554
Biological Process	GO:0045916	negative regulation of complement activation	Cr1l	IMP		Rat	PMID:11861390|RGD:625470
Biological Process	GO:0045957	negative regulation of complement activation, alternative pathway	CR1	IDA		Human	PMID:10531307
Biological Process	GO:0045959	negative regulation of complement activation, classical pathway	CR1	IDA		Human	PMID:10531307
Biological Process	GO:0045959	negative regulation of complement activation, classical pathway	CR1	IDA		Human	PMID:6910481
Biological Process	GO:1903660	negative regulation of complement-dependent cytotoxicity	CR1	IDA		Human	PMID:31862673
Biological Process	GO:0002638	negative regulation of immunoglobulin production	CR1	IDA		Human	PMID:22962438
Biological Process	GO:0032703	negative regulation of interleukin-2 production	CR1	IDA		Human	PMID:16360013
Biological Process	GO:1900099	negative regulation of plasma cell differentiation	CR1	IDA		Human	PMID:22962438
Biological Process	GO:1900004	negative regulation of serine-type endopeptidase activity	CR1	IDA		Human	PMID:6910481
Biological Process	GO:0042130	negative regulation of T cell proliferation	CR1	IDA		Human	PMID:16360013
Biological Process	GO:0032689	negative regulation of type II interferon production	CR1	IDA		Human	PMID:16360013
Biological Process	GO:0007009	plasma membrane organization	CR1	IDA		Human	PMID:24022490
Biological Process	GO:0001970	positive regulation of activation of membrane attack complex	CR1	IMP		Human	PMID:11981823
Biological Process	GO:0008284	positive regulation of cell population proliferation	CR1	IDA		Human	PMID:25742728
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	CR1	IDA		Human	PMID:25742728
Biological Process	GO:1900005	positive regulation of serine-type endopeptidase activity	CR1	IDA		Human	PMID:2972794
Biological Process	GO:0030449	regulation of complement activation	CR1L	IDA		Human	PMID:25284781
Biological Process	GO:0030449	regulation of complement activation	Cr1l	IMP	MGI:MGI:2158683	Mouse	PMID:18947875
Biological Process	GO:1903659	regulation of complement-dependent cytotoxicity	CR1L	IDA		Human	PMID:25284781

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern