Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CR2
  • Mouse genes Cr2
  • Rat genes Cr2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001848	complement binding	CR2	IDA		Human	PMID:11034390
Molecular Function	GO:0004875	complement receptor activity	Cr2	IMP	MGI:MGI:2154453	Mouse	PMID:11728339
Molecular Function	GO:0003677	DNA binding	CR2	IDA		Human	PMID:22885687
Molecular Function	GO:0034987	immunoglobulin receptor binding	CR2	IDA		Human	PMID:16172256
Molecular Function	GO:0005515	protein binding	CR2	IPI	UniProtKB:P01024	Human	PMID:11387479
Molecular Function	GO:0005515	protein binding	CR2	IPI	UniProtKB:P06734	Human	PMID:16172256
Molecular Function	GO:0005515	protein binding	CR2	IPI	UniProtKB:P01024	Human	PMID:21527715
Molecular Function	GO:0005515	protein binding	CR2	IPI	UniProtKB:Q00839	Human	PMID:7753047
Molecular Function	GO:0005515	protein binding	Cr2	IPI	PR:P01027	Mouse	PMID:11728339
Molecular Function	GO:0042803	protein homodimerization activity	CR2	IDA		Human	PMID:11728339
Molecular Function	GO:0038023	signaling receptor activity	Cr2	IDA		Mouse	PMID:11728339
Cellular Component	GO:0009986	cell surface	Cr2	IDA		Rat	PMID:12008031|RGD:127338250
Cellular Component	GO:0005737	cytoplasm	Cr2	IDA		Rat	PMID:9083278|RGD:127338251
Cellular Component	GO:0009897	external side of plasma membrane	Cr2	IDA		Mouse	PMID:15909309
Cellular Component	GO:0009897	external side of plasma membrane	Cr2	IDA		Mouse	PMID:11435465
Cellular Component	GO:0009897	external side of plasma membrane	Cr2	IDA		Mouse	PMID:14662849
Cellular Component	GO:0009897	external side of plasma membrane	Cr2	IDA		Mouse	PMID:8041705
Cellular Component	GO:0009897	external side of plasma membrane	Cr2	IDA		Mouse	PMID:19414760
Cellular Component	GO:0070062	extracellular exosome	CR2	HDA		Human	PMID:20458337
Cellular Component	GO:0005615	extracellular space	Cr2	IDA		Rat	PMID:26502875|RGD:11343913
Cellular Component	GO:0005634	nucleus	Cr2	IDA		Rat	PMID:9083278|RGD:127338251
Cellular Component	GO:0043235	receptor complex	CR2	IDA		Human	PMID:23382219
Biological Process	GO:0030183	B cell differentiation	CR2	IDA		Human	PMID:2995485
Biological Process	GO:0042100	B cell proliferation	CR2	IDA		Human	PMID:2995485
Biological Process	GO:0060348	bone development	Cr2	IGI		Mouse	PMID:19828624
Biological Process	GO:0051216	cartilage development	Cr2	IGI		Mouse	PMID:19828624
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Cr2	IGI		Mouse	PMID:19828624
Biological Process	GO:0006957	complement activation, alternative pathway	CR2	IMP		Human	PMID:11981823
Biological Process	GO:0006957	complement activation, alternative pathway	Cr2	IGI		Mouse	PMID:19828624
Biological Process	GO:0016064	immunoglobulin mediated immune response	Cr2	IGI		Mouse	PMID:19828624
Biological Process	GO:0006954	inflammatory response	Cr2	IGI		Mouse	PMID:19828624

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern