Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CRB2
  • Mouse genes Crb2
  • Rat genes Crb2
  • Zfish genes crb2a,crb2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Crb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	CRB2	IMP		Human	PMID:20299451
Molecular Function	GO:0005515	protein binding	CRB2	IPI	UniProtKB:Q9HCM4	Human	PMID:17920587
Molecular Function	GO:0005515	protein binding	Crb2	IPI	UniProtKB:Q9JLB2	Mouse	MGI:MGI:4454735|PMID:20399730
Molecular Function	GO:0005515	protein binding	Crb2	IPI	UniProtKB:Q8BYB9	Mouse	MGI:MGI:5700252|PMID:26496195
Molecular Function	GO:0044877	protein-containing complex binding	CRB2	IMP		Human	PMID:20299451
Cellular Component	GO:0045177	apical part of cell	Crb2	IDA		Mouse	PMID:25636444
Cellular Component	GO:0016324	apical plasma membrane	Crb2	IDA		Mouse	MGI:MGI:6467681|PMID:17920587
Cellular Component	GO:0016324	apical plasma membrane	Crb2	IDA		Mouse	MGI:MGI:5823085|PMID:27870829
Cellular Component	GO:0016324	apical plasma membrane	Crb2	IDA		Mouse	MGI:MGI:4454735|PMID:20399730
Cellular Component	GO:0016324	apical plasma membrane	Crb2	IDA		Mouse	MGI:MGI:5700252|PMID:26496195
Cellular Component	GO:0016327	apicolateral plasma membrane	Crb2	IDA		Mouse	MGI:MGI:6219868|PMID:26404741
Cellular Component	GO:0030054	cell junction	Crb2	IDA		Mouse	MGI:MGI:6219868|PMID:26404741
Cellular Component	GO:0005737	cytoplasm	Crb2	IDA		Mouse	MGI:MGI:6219868|PMID:26404741
Cellular Component	GO:0070062	extracellular exosome	CRB2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CRB2	HDA		Human	PMID:23533145
Cellular Component	GO:0005886	plasma membrane	crb2b	IDA		Zfish	PMID:22579223
Cellular Component	GO:0005886	plasma membrane	crb2a	IDA		Zfish	PMID:22579223
Cellular Component	GO:0032991	protein-containing complex	CRB2	IDA		Human	PMID:20299451
Cellular Component	GO:0032991	protein-containing complex	crb2b	IPI	ZFIN:ZDB-GENE-030616-450	Zfish	PMID:21262462
Cellular Component	GO:0032991	protein-containing complex	crb2a	IPI	ZFIN:ZDB-GENE-030616-450	Zfish	PMID:21262462
Cellular Component	GO:0035003	subapical complex	Crb2	IDA		Mouse	PMID:16885194
Biological Process	GO:0045176	apical protein localization	crb2a	IGI	ZFIN:ZDB-GENE-020712-1,ZFIN:ZDB-GENO-980202-307	Zfish	PMID:18628301
Biological Process	GO:0045176	apical protein localization	crb2a	IGI	ZFIN:ZDB-GENE-010319-35,ZFIN:ZDB-GENO-980202-307	Zfish	PMID:18628301
Biological Process	GO:0007420	brain development	crb2a	IMP	ZFIN:ZDB-GENO-090204-1	Zfish	PMID:19051268
Biological Process	GO:0043010	camera-type eye development	crb2a	IMP	ZFIN:ZDB-MRPHLNO-060822-1	Zfish	PMID:16713951
Biological Process	GO:0043010	camera-type eye development	crb2a	IMP	ZFIN:ZDB-MRPHLNO-060822-2	Zfish	PMID:16713951
Biological Process	GO:0098609	cell-cell adhesion	crb2b	IDA		Zfish	PMID:22579223
Biological Process	GO:0098609	cell-cell adhesion	crb2a	IDA		Zfish	PMID:22579223
Biological Process	GO:0098609	cell-cell adhesion	crb2a	IMP	ZFIN:ZDB-GENO-100525-2	Zfish	PMID:22579223
Biological Process	GO:0060271	cilium assembly	crb2b	IMP	ZFIN:ZDB-MRPHLNO-060612-1	Zfish	PMID:16713951
Biological Process	GO:0060271	cilium assembly	crb2b	IMP	ZFIN:ZDB-MRPHLNO-060822-4	Zfish	PMID:16713951
Biological Process	GO:0072359	circulatory system development	Crb2	IMP		Mouse	MGI:MGI:5296388|PMID:22072575
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	crb2a	IMP	ZFIN:ZDB-GENO-110823-11	Zfish	PMID:20362667
Biological Process	GO:0030010	establishment of cell polarity	Crb2	IMP		Mouse	MGI:MGI:5461109|PMID:23001562
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	crb2b	IGI	ZFIN:ZDB-MRPHLNO-060612-1,ZFIN:ZDB-MRPHLNO-060822-1,ZFIN:ZDB-MRPHLNO-140206-1,ZFIN:ZDB-MRPHLNO-140206-2	Zfish	PMID:24071007
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	crb2a	IGI	ZFIN:ZDB-MRPHLNO-060612-1,ZFIN:ZDB-MRPHLNO-060822-1,ZFIN:ZDB-MRPHLNO-140206-1,ZFIN:ZDB-MRPHLNO-140206-2	Zfish	PMID:24071007
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	crb2a	IMP	ZFIN:ZDB-GENO-100525-2	Zfish	PMID:20080584
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	crb2a	IMP	ZFIN:ZDB-GENO-980202-158	Zfish	PMID:16713951
Biological Process	GO:0042462	eye photoreceptor cell development	crb2b	IMP	ZFIN:ZDB-MRPHLNO-060612-1	Zfish	PMID:16713951
Biological Process	GO:0042462	eye photoreceptor cell development	crb2b	IMP	ZFIN:ZDB-MRPHLNO-060822-4	Zfish	PMID:16713951
Biological Process	GO:0072104	glomerular capillary formation	crb2b	IMP	ZFIN:ZDB-GENO-150526-5	Zfish	PMID:25557779
Biological Process	GO:0003094	glomerular filtration	crb2b	IMP	ZFIN:ZDB-MRPHLNO-091019-2	Zfish	PMID:19393641
Biological Process	GO:0003094	glomerular filtration	crb2b	IMP	ZFIN:ZDB-MRPHLNO-060612-1	Zfish	PMID:19393641
Biological Process	GO:0032835	glomerulus development	crb2b	IMP	ZFIN:ZDB-MRPHLNO-091019-2	Zfish	PMID:19393641
Biological Process	GO:0032835	glomerulus development	crb2b	IMP	ZFIN:ZDB-MRPHLNO-060612-1	Zfish	PMID:19393641
Biological Process	GO:0032835	glomerulus development	crb2b	IMP	ZFIN:ZDB-MRPHLNO-060612-1	Zfish	PMID:21566056
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	crb2b	IPI	ZFIN:ZDB-GENE-060612-1	Zfish	PMID:22579223
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	crb2a	IPI	ZFIN:ZDB-GENE-060610-1	Zfish	PMID:22579223
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	crb2b	IPI	ZFIN:ZDB-GENE-060610-1	Zfish	PMID:22579223
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	crb2a	IPI	ZFIN:ZDB-GENE-060612-1	Zfish	PMID:22579223
Biological Process	GO:0055111	ingression involved in gastrulation with mouth forming second	Crb2	IMP		Mouse	MGI:MGI:5823085|PMID:27870829
Biological Process	GO:0045199	maintenance of epithelial cell apical/basal polarity	Crb2	IMP		Mouse	MGI:MGI:5296388|PMID:22072575
Biological Process	GO:0001707	mesoderm formation	Crb2	IMP		Mouse	MGI:MGI:5823085|PMID:27870829
Biological Process	GO:0001707	mesoderm formation	Crb2	IMP		Mouse	MGI:MGI:5296388|PMID:22072575
Biological Process	GO:0010951	negative regulation of endopeptidase activity	CRB2	IMP		Human	PMID:20299451
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	crb2a	IEP		Zfish	PMID:21262462
Biological Process	GO:0014028	notochord formation	Crb2	IMP		Mouse	MGI:MGI:5296388|PMID:22072575
Biological Process	GO:0061113	pancreas morphogenesis	crb2b	IMP	ZFIN:ZDB-MRPHLNO-060822-4	Zfish	PMID:33544077
Biological Process	GO:0045494	photoreceptor cell maintenance	Crb2	IMP		Mouse	MGI:MGI:5461109|PMID:23001562
Biological Process	GO:0045494	photoreceptor cell maintenance	crb2b	IMP	ZFIN:ZDB-GENO-181024-1	Zfish	PMID:29368007
Biological Process	GO:0072015	podocyte development	crb2b	IMP	ZFIN:ZDB-GENO-150526-5	Zfish	PMID:25557779
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	Crb2	IMP		Mouse	MGI:MGI:5296388|PMID:22072575
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Crb2	IMP		Mouse	MGI:MGI:5296388|PMID:22072575
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	Crb2	IMP		Mouse	MGI:MGI:5823085|PMID:27870829
Biological Process	GO:0048793	pronephros development	crb2b	IMP	ZFIN:ZDB-MRPHLNO-060822-4	Zfish	PMID:16713951
Biological Process	GO:0048793	pronephros development	crb2b	IMP	ZFIN:ZDB-MRPHLNO-060612-1	Zfish	PMID:16713951
Biological Process	GO:0010470	regulation of gastrulation	Crb2	IMP		Mouse	MGI:MGI:5700252|PMID:26496195
Biological Process	GO:1902855	regulation of non-motile cilium assembly	crb2b	IMP	ZFIN:ZDB-GENO-090204-1	Zfish	PMID:28882989
Biological Process	GO:1902855	regulation of non-motile cilium assembly	crb2b	IGI	ZFIN:ZDB-GENO-180412-8	Zfish	PMID:28882989
Biological Process	GO:1902855	regulation of non-motile cilium assembly	crb2b	IGI	ZFIN:ZDB-GENO-180412-9	Zfish	PMID:28882989
Biological Process	GO:2000074	regulation of type B pancreatic cell development	crb2b	IMP	ZFIN:ZDB-MRPHLNO-060822-4	Zfish	PMID:33544077
Biological Process	GO:0001895	retina homeostasis	Crb2	IMP		Mouse	MGI:MGI:5461109|PMID:23001562
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	crb2b	IMP	ZFIN:ZDB-GENO-120726-11	Zfish	PMID:22579223
Biological Process	GO:0046549	retinal cone cell development	Crb2	IMP		Mouse	MGI:MGI:5461109|PMID:23001562
Biological Process	GO:0036060	slit diaphragm assembly	crb2b	IMP	ZFIN:ZDB-GENO-150526-5	Zfish	PMID:25557779
Biological Process	GO:0001756	somitogenesis	Crb2	IMP		Mouse	MGI:MGI:5296388|PMID:22072575
Biological Process	GO:0021591	ventricular system development	crb2a	IMP	ZFIN:ZDB-GENO-980202-158	Zfish	PMID:9007238

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern