Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CRBN
  • Mouse genes Crbn
  • Rat genes Crbn
  • Zfish genes crbn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Crbn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:Q16531	Human	PMID:20223979
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:Q9P286	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:P48729	Human	PMID:26131937
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:Q16531	Human	PMID:26131937
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:P48729	Human	PMID:26909574
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:Q16531	Human	PMID:26909574
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:Q9P286	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:Q8IVT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CRBN	IPI	UniProtKB:Q96A83-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Crbn	IPI	UniProtKB:O54822	Rat	PMID:19166841|RGD:8553753
Molecular Function	GO:0044325	transmembrane transporter binding	Crbn	IPI	RGD:620715	Rat	PMID:16045448|RGD:1581583
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	CRBN	IDA		Human	PMID:20223979
Cellular Component	GO:0005737	cytoplasm	CRBN	IDA		Human	PMID:20223979
Cellular Component	GO:0005634	nucleus	CRBN	IDA		Human	PMID:20223979
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Crbn	IDA		Rat	PMID:16045448|RGD:1581583
Cellular Component	GO:0000151	ubiquitin ligase complex	crbn	IDA		Zfish	PMID:20223979
Biological Process	GO:0008283	cell population proliferation	crbn	IMP	ZFIN:ZDB-MRPHLNO-190910-1	Zfish	PMID:31055217
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	crbn	IMP	ZFIN:ZDB-MRPHLNO-100503-5	Zfish	PMID:20223979
Biological Process	GO:0033333	fin development	crbn	IMP		Zfish	PMID:20223979|ZFIN:ZDB-PUB-100317-2
Biological Process	GO:0060173	limb development	crbn	IMP		Zfish	PMID:20223979|ZFIN:ZDB-PUB-100317-2
Biological Process	GO:0035641	locomotory exploration behavior	Crbn	IMP		Mouse	MGI:MGI:6150698|PMID:29530986
Biological Process	GO:1902607	negative regulation of large conductance calcium-activated potassium channel activity	Crbn	IMP		Mouse	MGI:MGI:6150698|PMID:29530986
Biological Process	GO:0034766	negative regulation of monoatomic ion transmembrane transport	Crbn	IDA		Rat	PMID:16045448|RGD:1581583
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	Crbn	IDA		Rat	PMID:16045448|RGD:1581583
Biological Process	GO:0071599	otic vesicle development	crbn	IMP		Zfish	PMID:20223979|ZFIN:ZDB-PUB-100317-2
Biological Process	GO:0071600	otic vesicle morphogenesis	crbn	IMP	ZFIN:ZDB-MRPHLNO-100503-5	Zfish	PMID:20223979
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	Crbn	IDA		Rat	PMID:16045448|RGD:1581583
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	CRBN	IMP		Human	PMID:34489457
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	CRBN	IMP		Human	PMID:20223979
Biological Process	GO:0016567	protein ubiquitination	CRBN	IMP		Human	PMID:20223979

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern