Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CRHR1,LINC02210-CRHR1
  • Mouse genes Crhr1
  • Rat genes Crhr1
  • Zfish genes crhr1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Crhr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	CRHR1	IDA		Human	PMID:18292205
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	Crhr1	IMP		Mouse	MGI:MGI:1267130|PMID:9655498
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	Crhr1	IMP	MGI:MGI:2178543	Mouse	PMID:11988580
Molecular Function	GO:0051424	corticotropin-releasing hormone binding	Crhr1	IDA		Rat	PMID:12942143|RGD:1358326
Molecular Function	GO:0043404	corticotropin-releasing hormone receptor activity	Crhr1	IDA		Rat	PMID:12942143|RGD:1358326
Molecular Function	GO:0004930	G protein-coupled receptor activity	Crhr1	IDA		Rat	PMID:11902119|RGD:727696
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Crhr1	IPI	RGD:2716	Rat	PMID:20548297|RGD:5491170
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Crhr1	IPI	RGD:628732	Rat	PMID:20548297|RGD:5491170
Molecular Function	GO:0042277	peptide binding	Crhr1	IDA		Rat	PMID:15049707|RGD:5490990
Molecular Function	GO:0042277	peptide binding	Crhr1	IPI	PubChem_Substance:3888616	Rat	PMID:15932935|RGD:1626241
Molecular Function	GO:0005515	protein binding	CRHR1	IPI	UniProtKB:P06850	Human	PMID:18801728
Molecular Function	GO:0005515	protein binding	CRHR1	IPI	UniProtKB:P06850	Human	PMID:20966082
Molecular Function	GO:0005515	protein binding	CRHR1	IPI	UniProtKB:O88382	Human	PMID:26352593
Molecular Function	GO:0005515	protein binding	CRHR1	IPI	UniProtKB:Q63622	Human	PMID:26352593
Molecular Function	GO:0005515	protein binding	CRHR1	IPI	UniProtKB:Q12959	Human	PMID:30126976
Molecular Function	GO:0005515	protein binding	CRHR1	IPI	UniProtKB:Q14160	Human	PMID:30126976
Molecular Function	GO:0005515	protein binding	Crhr1	IPI	UniProtKB:P70175|UniProtKB:Q62696	Mouse	MGI:MGI:6189341|PMID:26352593
Molecular Function	GO:0005515	protein binding	Crhr1	IPI	UniProtKB:Q62108	Mouse	MGI:MGI:6189341|PMID:26352593
Molecular Function	GO:0005515	protein binding	Crhr1	IPI	UniProtKB:P55090	Rat	PMID:24290358|RGD:8554713
Molecular Function	GO:0044877	protein-containing complex binding	Crhr1	IPI	RGD:620770|RGD:619749	Rat	PMID:20548297|RGD:5491170
Cellular Component	GO:0045177	apical part of cell	Crhr1	IDA		Rat	PMID:12911751|RGD:1626245
Cellular Component	GO:0030425	dendrite	Crhr1	IDA		Rat	PMID:12911751|RGD:1626245
Cellular Component	GO:0016020	membrane	CRHR1	IDA		Human	PMID:23863939
Cellular Component	GO:0016020	membrane	Crhr1	IDA		Rat	PMID:15932935|RGD:1626241
Cellular Component	GO:0005771	multivesicular body	Crhr1	IDA		Rat	PMID:12911751|RGD:1626245
Cellular Component	GO:0043025	neuronal cell body	Crhr1	IDA		Rat	PMID:12911751|RGD:1626245
Cellular Component	GO:0005886	plasma membrane	CRHR1	IDA		Human	PMID:18292205
Cellular Component	GO:0005886	plasma membrane	Crhr1	IDA		Rat	PMID:21277852|RGD:5491003
Cellular Component	GO:0005802	trans-Golgi network	Crhr1	IDA		Rat	PMID:12911751|RGD:1626245
Cellular Component	GO:0031982	vesicle	Crhr1	IDA		Rat	PMID:12911751|RGD:1626245
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	CRHR1	IDA		Human	PMID:18292205
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Crhr1	IMP		Mouse	MGI:MGI:1267130|PMID:9655498
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Crhr1	IDA		Rat	PMID:15932935|RGD:1626241
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	Crhr1	IDA		Rat	PMID:11784785|RGD:70397
Biological Process	GO:0030325	adrenal gland development	Crhr1	IMP		Mouse	MGI:MGI:1267130|PMID:9655498
Biological Process	GO:0048148	behavioral response to cocaine	Crhr1	IMP		Rat	PMID:21813699|RGD:5147489
Biological Process	GO:0048149	behavioral response to ethanol	Crhr1	IMP	MGI:MGI:2178543	Mouse	PMID:11988580
Biological Process	GO:0048266	behavioral response to pain	Crhr1	IMP		Rat	PMID:17550594|RGD:1626231
Biological Process	GO:0071376	cellular response to corticotropin-releasing hormone stimulus	CRHR1	IDA		Human	PMID:18292205
Biological Process	GO:0071376	cellular response to corticotropin-releasing hormone stimulus	Crhr1	IMP		Mouse	MGI:MGI:1267130|PMID:9655498
Biological Process	GO:0051458	corticotropin secretion	Crhr1	IMP		Mouse	MGI:MGI:1267130|PMID:9655498
Biological Process	GO:0030855	epithelial cell differentiation	Crhr1	IMP		Rat	PMID:20551459|RGD:5130947
Biological Process	GO:0042596	fear response	Crhr1	IMP		Mouse	MGI:MGI:1267130|PMID:9655498
Biological Process	GO:0007631	feeding behavior	Crhr1	IMP		Rat	PMID:12559107|RGD:704396
Biological Process	GO:0051867	general adaptation syndrome, behavioral process	Crhr1	IMP	MGI:MGI:2178543	Mouse	PMID:11988580
Biological Process	GO:0021854	hypothalamus development	Crhr1	IEP		Rat	PMID:20002962|RGD:5130950
Biological Process	GO:0035641	locomotory exploration behavior	Crhr1	IMP		Rat	PMID:9299637|RGD:5508842
Biological Process	GO:0060291	long-term synaptic potentiation	Crhr1	IMP		Rat	PMID:19376201|RGD:5130954
Biological Process	GO:0007613	memory	Crhr1	IMP		Rat	PMID:15932935|RGD:1626241
Biological Process	GO:0032811	negative regulation of epinephrine secretion	Crhr1	IMP		Rat	PMID:12606499|RGD:704397
Biological Process	GO:2000252	negative regulation of feeding behavior	Crhr1	IMP		Rat	PMID:14512273|RGD:1304435
Biological Process	GO:1901215	negative regulation of neuron death	Crhr1	IMP		Rat	PMID:11784785|RGD:70397
Biological Process	GO:1901386	negative regulation of voltage-gated calcium channel activity	CRHR1	IDA		Human	PMID:18292205
Biological Process	GO:0007218	neuropeptide signaling pathway	Crhr1	IDA		Rat	PMID:11784785|RGD:70397
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Crhr1	IDA		Rat	PMID:15932935|RGD:1626241
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Crhr1	IMP		Rat	PMID:20682782|RGD:5491010
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Crhr1	IMP		Rat	PMID:16513211|RGD:1626238
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Crhr1	IMP		Rat	PMID:18209484|RGD:5130941
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Crhr1	IMP		Rat	PMID:18209484|RGD:5130941
Biological Process	GO:0010578	regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway	CRHR1	IMP		Human	PMID:23863939
Biological Process	GO:2000852	regulation of corticosterone secretion	Crhr1	IMP		Mouse	MGI:MGI:1267130|PMID:9655498
Biological Process	GO:0048167	regulation of synaptic plasticity	Crhr1	IMP		Rat	PMID:17079348|RGD:1626232
Biological Process	GO:0051602	response to electrical stimulus	Crhr1	IMP		Rat	PMID:17015825|RGD:1626233
Biological Process	GO:0001666	response to hypoxia	Crhr1	IMP		Rat	PMID:16099461|RGD:1626240
Biological Process	GO:0035902	response to immobilization stress	Crhr1	IEP		Rat	PMID:21664419|RGD:5490546
Biological Process	GO:0008542	visual learning	Crhr1	IMP		Rat	PMID:15932935|RGD:1626241

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern