Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CRKL
  • Mouse genes Crkl
  • Rat genes Crkl
  • Zfish genes crkl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Crkl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	CRKL	HDA		Human	PMID:25468996
Molecular Function	GO:0042802	identical protein binding	CRKL	IPI	UniProtKB:P46109	Human	PMID:17161365
Molecular Function	GO:0042802	identical protein binding	CRKL	IPI	UniProtKB:P46109	Human	PMID:19168626
Molecular Function	GO:0001784	phosphotyrosine residue binding	CRKL	IPI	UniProtKB:O84462	Human	PMID:20624904
Molecular Function	GO:0001784	phosphotyrosine residue binding	CRKL	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q13191	Human	PMID:10022120
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P21860	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q9EQG6	Human	PMID:16284401
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P00519	Human	PMID:16443220
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q13905	Human	PMID:16443220
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P22681	Human	PMID:16982329
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q08460	Human	PMID:17065230
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q9H7D0	Human	PMID:19004829
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P05556	Human	PMID:19168626
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P00519	Human	PMID:22286129
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P00533	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P17948	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q13480	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q96PD2	Human	PMID:23770091
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P16234	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q13480	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P22681	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q13191	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q13905	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P36888	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q13480	Human	PMID:31585087
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:A2A3K4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P07947	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P51451	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P62333	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q70EK8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P22681	Human	PMID:8626543
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:P16234	Human	PMID:9546424
Molecular Function	GO:0005515	protein binding	CRKL	IPI	UniProtKB:Q92918	Human	PMID:9788432
Molecular Function	GO:0005515	protein binding	Crkl	IPI	PR:Q3TTA7	Mouse	PMID:12697763
Molecular Function	GO:0005515	protein binding	Crkl	IPI	PR:P97318	Mouse	PMID:15062102
Molecular Function	GO:0005515	protein binding	Crkl	IPI	UniProtKB:Q8NDW8	Mouse	PMID:12697763
Molecular Function	GO:0005515	protein binding	Crkl	IPI	PR:P21803	Mouse	PMID:16399079
Molecular Function	GO:0005515	protein binding	Crkl	IPI	PR:Q62417	Mouse	PMID:26527617
Molecular Function	GO:0005515	protein binding	Crkl	IPI	PR:P16092	Mouse	PMID:16399079
Molecular Function	GO:0005515	protein binding	Crkl	IPI	MGI:MGI:104580	Mouse	PMID:12671687
Molecular Function	GO:0005515	protein binding	Crkl	IPI	PR:P16092	Mouse	PMID:19307307
Molecular Function	GO:0005515	protein binding	Crkl	IPI	PR:Q3UTJ2	Mouse	PMID:26527617
Molecular Function	GO:0005515	protein binding	Crkl	IPI	RGD:3773	Rat	PMID:10720695|RGD:7488900
Molecular Function	GO:0005515	protein binding	Crkl	IPI	RGD:3774	Rat	PMID:10720695|RGD:7488900
Molecular Function	GO:0003723	RNA binding	CRKL	HDA		Human	PMID:22658674
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	CRKL	IDA		Human	PMID:29581031
Cellular Component	GO:0005737	cytoplasm	Crkl	IDA		Rat	PMID:10720695|RGD:7488900
Cellular Component	GO:0005829	cytosol	CRKL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098890	extrinsic component of postsynaptic membrane	Crkl	IDA		Mouse	PMID:21041412
Cellular Component	GO:0031594	neuromuscular junction	Crkl	IDA		Mouse	PMID:21041412
Cellular Component	GO:0031594	neuromuscular junction	Crkl	IMP		Mouse	PMID:21041412
Cellular Component	GO:0005654	nucleoplasm	CRKL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032991	protein-containing complex	Crkl	IDA		Mouse	PMID:26527617
Cellular Component	GO:0045202	synapse	Crkl	IDA		Mouse	PMID:26527617
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	Crkl	IGI	MGI:MGI:1924574	Mouse	PMID:26527617
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	Crkl	IGI	MGI:MGI:700014	Mouse	PMID:26527617
Biological Process	GO:0090630	activation of GTPase activity	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:25621495
Biological Process	GO:0090630	activation of GTPase activity	Crkl	IGI	MGI:MGI:97302	Mouse	PMID:25621495
Biological Process	GO:0090630	activation of GTPase activity	Crkl	IGI	MGI:MGI:104580	Mouse	PMID:25621495
Biological Process	GO:0009887	animal organ morphogenesis	Crkl	IMP	MGI:MGI:1931805	Mouse	PMID:11242111
Biological Process	GO:0009952	anterior/posterior pattern specification	Crkl	IGI	MGI:MGI:98493	Mouse	PMID:16399080
Biological Process	GO:0001783	B cell apoptotic process	Crkl	IMP	MGI:MGI:4435697	Mouse	PMID:29581031
Biological Process	GO:0001568	blood vessel development	Crkl	IGI	MGI:MGI:98493	Mouse	PMID:16399080
Biological Process	GO:0060326	cell chemotaxis	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:25621495
Biological Process	GO:0098761	cellular response to interleukin-7	Crkl	IDA		Mouse	PMID:29581031
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	CRKL	IMP		Human	PMID:23959425
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Crkl	IDA		Mouse	PMID:29581031
Biological Process	GO:0098749	cerebellar neuron development	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:19074029
Biological Process	GO:0021987	cerebral cortex development	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:19074029
Biological Process	GO:1904888	cranial skeletal system development	Crkl	IMP	MGI:MGI:5510713	Mouse	PMID:25565927
Biological Process	GO:0016358	dendrite development	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:19074029
Biological Process	GO:0086100	endothelin receptor signaling pathway	Crkl	IMP	MGI:MGI:5510713	Mouse	PMID:25565927
Biological Process	GO:0030010	establishment of cell polarity	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:25621495
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Crkl	IMP	MGI:MGI:1931805	Mouse	PMID:16399079
Biological Process	GO:0007507	heart development	Crkl	IGI	MGI:MGI:98493	Mouse	PMID:16399080
Biological Process	GO:0035685	helper T cell diapedesis	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:25621495
Biological Process	GO:0021766	hippocampus development	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:19074029
Biological Process	GO:0006629	lipid metabolic process	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:29581031
Biological Process	GO:0008584	male gonad development	Crkl	IMP	MGI:MGI:5904959	Mouse	PMID:28439006
Biological Process	GO:0008584	male gonad development	Crkl	IMP	MGI:MGI:4435697	Mouse	PMID:28439006
Biological Process	GO:0008584	male gonad development	Crkl	IMP	MGI:MGI:5825167	Mouse	PMID:28439006
Biological Process	GO:0007520	myoblast fusion	crkl	IMP	ZFIN:ZDB-MRPHLNO-080109-3	Zfish	PMID:17670792
Biological Process	GO:0007520	myoblast fusion	crkl	IMP	ZFIN:ZDB-MRPHLNO-080109-4	Zfish	PMID:17670792
Biological Process	GO:0010629	negative regulation of gene expression	CRKL	IMP		Human	PMID:23959425
Biological Process	GO:0001933	negative regulation of protein phosphorylation	CRKL	IMP		Human	PMID:23959425
Biological Process	GO:0001764	neuron migration	Crkl	IMP	MGI:MGI:1931805	Mouse	PMID:17394141
Biological Process	GO:0001764	neuron migration	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:19074029
Biological Process	GO:0003151	outflow tract morphogenesis	Crkl	IMP	MGI:MGI:5763397	Mouse	PMID:25658046
Biological Process	GO:0003151	outflow tract morphogenesis	Crkl	IMP	MGI:MGI:5763398	Mouse	PMID:25658046
Biological Process	GO:0060017	parathyroid gland development	Crkl	IGI	MGI:MGI:98493	Mouse	PMID:16399080
Biological Process	GO:0007389	pattern specification process	Crkl	IGI	MGI:MGI:98493	Mouse	PMID:16399080
Biological Process	GO:0060465	pharynx development	Crkl	IMP	MGI:MGI:5510713	Mouse	PMID:25565927
Biological Process	GO:0008284	positive regulation of cell population proliferation	CRKL	IMP		Human	PMID:25540073
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	CRKL	IMP		Human	PMID:23959425
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Crkl	IMP	MGI:MGI:1931805	Mouse	PMID:16399079
Biological Process	GO:1903977	positive regulation of glial cell migration	CRKL	IMP		Human	PMID:23959425
Biological Process	GO:0043410	positive regulation of MAPK cascade	Crkl	IDA		Mouse	PMID:19307307
Biological Process	GO:0001934	positive regulation of protein phosphorylation	CRKL	IMP		Human	PMID:23959425
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	CRKL	IMP		Human	PMID:19004829
Biological Process	GO:0098698	postsynaptic specialization assembly	Crkl	IDA		Mouse	PMID:21041412
Biological Process	GO:0098698	postsynaptic specialization assembly	Crkl	IMP		Mouse	PMID:21041412
Biological Process	GO:0048793	pronephros development	crkl	IMP	ZFIN:ZDB-CRISPR-210524-5,ZFIN:ZDB-CRISPR-210524-6,ZFIN:ZDB-CRISPR-210524-7,ZFIN:ZDB-CRISPR-210524-8	Zfish	PMID:32535035
Biological Process	GO:0072114	pronephros morphogenesis	crkl	IMP	ZFIN:ZDB-MRPHLNO-080109-3	Zfish	PMID:28121514
Biological Process	GO:0072114	pronephros morphogenesis	crkl	IMP	ZFIN:ZDB-CRISPR-170607-3	Zfish	PMID:28121514
Biological Process	GO:0038026	reelin-mediated signaling pathway	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:18477607
Biological Process	GO:0038026	reelin-mediated signaling pathway	Crkl	IMP	MGI:MGI:1931805	Mouse	PMID:17394141
Biological Process	GO:0038026	reelin-mediated signaling pathway	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:19074029
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:25621495
Biological Process	GO:0001558	regulation of cell growth	Crkl	IDA		Mouse	PMID:19307307
Biological Process	GO:0050773	regulation of dendrite development	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:18477607
Biological Process	GO:0010468	regulation of gene expression	Crkl	IMP	MGI:MGI:1931805	Mouse	PMID:16399079
Biological Process	GO:0010468	regulation of gene expression	Crkl	IMP	MGI:MGI:4435697	Mouse	PMID:28439006
Biological Process	GO:0010468	regulation of gene expression	Crkl	IMP	MGI:MGI:5825167	Mouse	PMID:28439006
Biological Process	GO:0010468	regulation of gene expression	Crkl	IMP	MGI:MGI:5904959	Mouse	PMID:28439006
Biological Process	GO:0002685	regulation of leukocyte migration	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:25621495
Biological Process	GO:1904393	regulation of skeletal muscle acetylcholine-gated channel clustering	Crkl	IGI	MGI:MGI:700014	Mouse	PMID:26527617
Biological Process	GO:1904393	regulation of skeletal muscle acetylcholine-gated channel clustering	Crkl	IGI	MGI:MGI:1924574	Mouse	PMID:26527617
Biological Process	GO:2000404	regulation of T cell migration	Crkl	IGI	MGI:MGI:88508	Mouse	PMID:25621495
Biological Process	GO:0071774	response to fibroblast growth factor	Crkl	IMP		Mouse	PMID:19307307
Biological Process	GO:0071774	response to fibroblast growth factor	Crkl	IMP	MGI:MGI:1931805	Mouse	PMID:16399079
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	Crkl	IMP	MGI:MGI:5510713	Mouse	PMID:25565927
Biological Process	GO:0007338	single fertilization	Crkl	IMP	MGI:MGI:5904959	Mouse	PMID:28439006
Biological Process	GO:0007338	single fertilization	Crkl	IMP	MGI:MGI:4435697	Mouse	PMID:28439006
Biological Process	GO:0007338	single fertilization	Crkl	IMP	MGI:MGI:5825167	Mouse	PMID:28439006
Biological Process	GO:0007283	spermatogenesis	Crkl	IMP	MGI:MGI:4435697	Mouse	PMID:28439006
Biological Process	GO:0007283	spermatogenesis	Crkl	IMP	MGI:MGI:5825167	Mouse	PMID:28439006
Biological Process	GO:0007283	spermatogenesis	Crkl	IMP	MGI:MGI:5904959	Mouse	PMID:28439006
Biological Process	GO:0050852	T cell receptor signaling pathway	Crkl	IDA		Mouse	PMID:18305217
Biological Process	GO:0048538	thymus development	Crkl	IGI	MGI:MGI:98493	Mouse	PMID:16399080
Biological Process	GO:0001655	urogenital system development	Crkl	IMP	MGI:MGI:4435697	Mouse	PMID:28439006
Biological Process	GO:0001655	urogenital system development	Crkl	IMP	MGI:MGI:5825167	Mouse	PMID:28439006
Biological Process	GO:0001655	urogenital system development	Crkl	IMP	MGI:MGI:5904959	Mouse	PMID:28439006

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern