Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CRLF2
  • Mouse genes Crlf2
  • Rat genes Crlf2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Crlf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	Crlf2	IDA		Rat	PMID:11891057|RGD:70482
Molecular Function	GO:0004896	cytokine receptor activity	CRLF2	IDA		Human	PMID:11418668
Molecular Function	GO:0004896	cytokine receptor activity	CRLF2	IMP		Human	PMID:17242164
Molecular Function	GO:0005515	protein binding	Crlf2	IPI	UniProtKB:Q9JIE6	Mouse	MGI:MGI:5916195|PMID:24632570
Cellular Component	GO:0009897	external side of plasma membrane	Crlf2	IDA		Mouse	PMID:15488943
Biological Process	GO:0019221	cytokine-mediated signaling pathway	CRLF2	IDA		Human	PMID:11418668
Biological Process	GO:0002381	immunoglobulin production involved in immunoglobulin-mediated immune response	Crlf2	IDA		Mouse	PMID:16142237
Biological Process	GO:0006954	inflammatory response	Crlf2	IMP	MGI:MGI:3039288	Mouse	PMID:16142237
Biological Process	GO:0008284	positive regulation of cell population proliferation	CRLF2	IDA		Human	PMID:11418668
Biological Process	GO:0032754	positive regulation of interleukin-5 production	CRLF2	IMP		Human	PMID:17242164
Biological Process	GO:0033005	positive regulation of mast cell activation	CRLF2	IMP		Human	PMID:17242164
Biological Process	GO:1904894	positive regulation of receptor signaling pathway via STAT	CRLF2	IDA		Human	PMID:11418668
Biological Process	GO:0035745	T-helper 2 cell cytokine production	Crlf2	IDA		Mouse	PMID:16142237

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern