Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CRP
  • Mouse genes Crp
  • Rat genes Crp
  • Zfish genes crp,crp1,crp2,crp6,crp7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Crp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	CRP	IDA		Human	PMID:23544079
Molecular Function	GO:0015485	cholesterol binding	Crp	IDA		Rat	PMID:15766555|RGD:1580272
Molecular Function	GO:0015485	cholesterol binding	crp7	IDA		Zfish	PMID:30653529
Molecular Function	GO:0015485	cholesterol binding	crp	IDA		Zfish	PMID:30653529
Molecular Function	GO:0015485	cholesterol binding	crp2	IDA		Zfish	PMID:30653529
Molecular Function	GO:0001849	complement component C1q complex binding	CRP	IDA		Human	PMID:23544079
Molecular Function	GO:0042802	identical protein binding	CRP	IPI	UniProtKB:P02741	Human	PMID:16642000
Molecular Function	GO:0042802	identical protein binding	CRP	IPI	UniProtKB:P02741	Human	PMID:18786923
Molecular Function	GO:0042802	identical protein binding	CRP	IPI	UniProtKB:P02741	Human	PMID:19084272
Molecular Function	GO:0042802	identical protein binding	CRP	IPI	UniProtKB:P02741	Human	PMID:19680263
Molecular Function	GO:0042802	identical protein binding	CRP	IPI	UniProtKB:P02741	Human	PMID:19850925
Molecular Function	GO:0042802	identical protein binding	Crp	IPI	RGD:2411	Rat	PMID:1737750|RGD:1298812
Molecular Function	GO:0030169	low-density lipoprotein particle binding	CRP	IDA		Human	PMID:18322245
Molecular Function	GO:0030169	low-density lipoprotein particle binding	Crp	IDA		Rat	PMID:3800992|RGD:9586005
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	CRP	IPI	UniProtKB:Q9TTK7	Human	PMID:24141169
Molecular Function	GO:0008142	oxysterol binding	crp7	IDA		Zfish	PMID:30653529
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603	Human	PMID:17293598
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603	Human	PMID:17339482
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603-1	Human	PMID:17399790
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603-2	Human	PMID:17399790
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P31995	Human	PMID:17785206
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603	Human	PMID:18786923
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P02769	Human	PMID:19084272
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603	Human	PMID:19084272
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:Q92496-1	Human	PMID:19084272
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:Q92496-3	Human	PMID:19084272
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603	Human	PMID:19680263
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603	Human	PMID:19850925
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603	Human	PMID:20042240
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:Q02985	Human	PMID:20042240
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:Q92496-1	Human	PMID:20042240
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:O00602	Human	PMID:21037097
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603-1	Human	PMID:21930971
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603-2	Human	PMID:21930971
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P02769	Human	PMID:21979047
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:Q96IJ6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:Q5KU26	Human	PMID:26922829
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603	Human	PMID:28533443
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603:PRO_0000005894	Human	PMID:28533443
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:Q02985	Human	PMID:28533443
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:Q03591	Human	PMID:28533443
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:Q92496-1	Human	PMID:28533443
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:Q92496-3	Human	PMID:28533443
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:Q9BXR6:PRO_0000005900	Human	PMID:28533443
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603	Human	PMID:29374201
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603-2	Human	PMID:29374201
Molecular Function	GO:0005515	protein binding	CRP	IPI	UniProtKB:P08603:PRO_0000005894	Human	PMID:29374201
Molecular Function	GO:0005515	protein binding	Crp	IPI	RGD:2232	Rat	PMID:12871224|RGD:5129545
Cellular Component	GO:0005615	extracellular space	CRP	IDA		Human	PMID:21323571
Cellular Component	GO:0005615	extracellular space	CRP	IDA		Human	PMID:23544079
Cellular Component	GO:0005615	extracellular space	Crp	IDA		Rat	PMID:1737750|RGD:1298812
Cellular Component	GO:0005615	extracellular space	Crp	IDA		Rat	PMID:7056568|RGD:9585996
Cellular Component	GO:0030175	filopodium	Crp	IDA		Rat	PMID:22090504|RGD:6904210
Cellular Component	GO:0030426	growth cone	Crp	IDA		Rat	PMID:22090504|RGD:6904210
Biological Process	GO:0006953	acute-phase response	Crp	IEP		Rat	PMID:7056568|RGD:9585996
Biological Process	GO:0007568	aging	Crp	IEP		Rat	PMID:21835237|RGD:6482314
Biological Process	GO:0071277	cellular response to calcium ion	Crp	IDA		Rat	PMID:22090504|RGD:6904210
Biological Process	GO:0071354	cellular response to interleukin-6	Crp	IEP		Rat	PMID:20100497|RGD:9586010
Biological Process	GO:0071732	cellular response to nitric oxide	Crp	IEP		Rat	PMID:9704587|RGD:9586007
Biological Process	GO:0006958	complement activation, classical pathway	Crp	IMP		Rat	PMID:16367929|RGD:1580273
Biological Process	GO:0051607	defense response to virus	crp6	IDA		Zfish	PMID:28915434
Biological Process	GO:0051607	defense response to virus	crp1	IDA		Zfish	PMID:28915434
Biological Process	GO:0051607	defense response to virus	crp	IDA		Zfish	PMID:28915434
Biological Process	GO:0051607	defense response to virus	crp7	IDA		Zfish	PMID:28915434
Biological Process	GO:0051607	defense response to virus	crp2	IDA		Zfish	PMID:28915434
Biological Process	GO:0010888	negative regulation of lipid storage	CRP	IDA		Human	PMID:18322245
Biological Process	GO:0010745	negative regulation of macrophage derived foam cell differentiation	CRP	IDA		Human	PMID:18322245
Biological Process	GO:0032945	negative regulation of mononuclear cell proliferation	CRP	IDA		Human	PMID:29202702
Biological Process	GO:0032929	negative regulation of superoxide anion generation	Crp	IDA		Rat	PMID:9767445|RGD:9586000
Biological Process	GO:1900006	positive regulation of dendrite development	Crp	IMP		Rat	PMID:22090504|RGD:6904210
Biological Process	GO:0010628	positive regulation of gene expression	CRP	IDA		Human	PMID:24141169
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Crp	IDA		Rat	PMID:9767445|RGD:9586000
Biological Process	GO:0032930	positive regulation of superoxide anion generation	CRP	IDA		Human	PMID:24141169
Biological Process	GO:0051258	protein polymerization	Crp	IDA		Rat	PMID:1737750|RGD:1298812
Biological Process	GO:0032677	regulation of interleukin-8 production	CRP	IDA		Human	PMID:21037097
Biological Process	GO:0010988	regulation of low-density lipoprotein particle clearance	Crp	IDA		Rat	PMID:8305421|RGD:9586002
Biological Process	GO:0009617	response to bacterium	crp2	IDA		Zfish	PMID:16630661
Biological Process	GO:0032355	response to estradiol	Crp	IEP		Rat	PMID:7918685|RGD:9585993
Biological Process	GO:0045471	response to ethanol	Crp	IEP		Rat	PMID:22521742|RGD:6903281
Biological Process	GO:0001666	response to hypoxia	Crp	IEP		Rat	PMID:21158023|RGD:5131294
Biological Process	GO:0010288	response to lead ion	Crp	IEP		Rat	PMID:21378372|RGD:5131295
Biological Process	GO:0031667	response to nutrient levels	Crp	IEP		Rat	PMID:25612518|RGD:15045599
Biological Process	GO:0009314	response to radiation	Crp	IEP		Rat	PMID:24308182|RGD:8695929
Biological Process	GO:0033574	response to testosterone	Crp	IEP		Rat	PMID:1978818|RGD:9586009
Biological Process	GO:0042310	vasoconstriction	CRP	IDA		Human	PMID:24141169
Biological Process	GO:0042310	vasoconstriction	CRP	IMP		Human	PMID:24141169
Biological Process	GO:0042060	wound healing	Crp	IMP		Rat	PMID:22447201|RGD:6903314

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern