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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Cry1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cry1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0140297DNA-binding transcription factor bindingCry1IPIUniProtKB:O08785|UniProtKB:Q9WTL8MouseMGI:MGI:5567903|PMID:21613214
Molecular FunctionGO:0003690double-stranded DNA bindingCRY1IDAHumanPMID:9801304
Molecular FunctionGO:0003690double-stranded DNA bindingCry1IDAMouseMGI:MGI:1314997|PMID:9801304
Molecular FunctionGO:0070888E-box bindingCry1IDAMouseMGI:MGI:5292598|PMID:21768648
Molecular FunctionGO:0070888E-box bindingCry1IDAMouseMGI:MGI:5545849|PMID:24385426
Molecular FunctionGO:0070888E-box bindingCry1IDAMouseMGI:MGI:5009503|PMID:19129230
Molecular FunctionGO:0070888E-box bindingCry1IDAMouseMGI:MGI:5464222|PMID:23133559
Molecular FunctionGO:0042826histone deacetylase bindingCry1IPIUniProtKB:O09106|UniProtKB:P70288MouseMGI:MGI:5567917|PMID:15226430
Molecular FunctionGO:0019900kinase bindingCry1IPIUniProtKB:P97313MouseMGI:MGI:5554971|PMID:24158435
Molecular FunctionGO:0016922nuclear receptor bindingCRY1IPIUniProtKB:P20393HumanPMID:22170608
Molecular FunctionGO:0016922nuclear receptor bindingCry1IPIUniProtKB:P04150|UniProtKB:P06537|UniProtKB:P10275|UniProtKB:P35398|UniProtKB:P51449MouseMGI:MGI:5302136|PMID:22170608
Molecular FunctionGO:0019902phosphatase bindingCRY1IPIUniProtKB:P53041HumanPMID:9383998
Molecular FunctionGO:0005515protein bindingCRY1IPIUniProtKB:Q9UKT7HumanPMID:17463251
Molecular FunctionGO:0005515protein bindingCRY1IPIUniProtKB:P63092HumanPMID:20852621
Molecular FunctionGO:0005515protein bindingCRY1IPIUniProtKB:O54943HumanPMID:21613214
Molecular FunctionGO:0005515protein bindingCRY1IPIUniProtKB:O54943HumanPMID:21680841
Molecular FunctionGO:0005515protein bindingCRY1IPIUniProtKB:O14744HumanPMID:23133559
Molecular FunctionGO:0005515protein bindingCRY1IPIUniProtKB:Q8CIG8HumanPMID:23133559
Molecular FunctionGO:0005515protein bindingCRY1IPIUniProtKB:Q9NZJ0HumanPMID:26431207
Molecular FunctionGO:0005515protein bindingCRY1IPIUniProtKB:P41235HumanPMID:30530698
Molecular FunctionGO:0005515protein bindingCRY1IPIUniProtKB:Q99614HumanPMID:9383998
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q9CQV6MouseMGI:MGI:6208175|PMID:29937374
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O54943|UniProtKB:P06537-1MouseMGI:MGI:5302136|PMID:22170608
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q8BFZ4MouseMGI:MGI:5487698|PMID:23452856
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O54943MouseMGI:MGI:5508702|PMID:23079727
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q8C4V4MouseMGI:MGI:6270295|PMID:30500822
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O35973|UniProtKB:O54943|UniProtKB:P67870MouseMGI:MGI:5489023|PMID:23555304
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q9WTL8MouseMGI:MGI:4881368|PMID:20832105
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O08785MouseMGI:MGI:3807721|PMID:18662546
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q8C4V4MouseMGI:MGI:3715674|PMID:17462724
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:P67870|UniProtKB:P67871MouseMGI:MGI:5700567|PMID:26562092
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O08785|UniProtKB:Q61188|UniProtKB:Q9WTL8MouseMGI:MGI:3694308|PMID:16717091
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q8BFZ4|UniProtKB:Q8C4V4MouseMGI:MGI:5470183|PMID:23452855
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q8C4V4MouseMGI:MGI:5470183|PMID:23452855
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q9R1X4MouseMGI:MGI:5567851|PMID:24489120
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O35973|UniProtKB:O54943MouseMGI:MGI:5568139|PMID:24737000
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O54943MouseMGI:MGI:5470183|PMID:23452855
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q9R1E0MouseMGI:MGI:5914352|PMID:28790135
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O08785|UniProtKB:Q9WTL8MouseMGI:MGI:3652692|PMID:16777965
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q9WTL8-2MouseMGI:MGI:3771941|PMID:18075593
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O54943MouseMGI:MGI:5586772|PMID:24855952
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q8BFZ4|UniProtKB:Q8C4V4MouseMGI:MGI:5487698|PMID:23452856
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q3U1J4|UniProtKB:Q62318|UniProtKB:Q8VC57MouseMGI:MGI:6253084|PMID:27123980
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O35627|UniProtKB:O54915|UniProtKB:P06537|UniProtKB:P19091|UniProtKB:P35396|UniProtKB:P48281|UniProtKB:P49698MouseMGI:MGI:5913754|PMID:28751364
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O54943MouseMGI:MGI:5567903|PMID:21613214
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q9WTL8MouseMGI:MGI:5568139|PMID:24737000
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:P12970|UniProtKB:P62908|UniProtKB:P62918|UniProtKB:Q7TPV4|UniProtKB:Q8R1A4|UniProtKB:Q8VEK3MouseMGI:MGI:5009503|PMID:19129230
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:P23204|UniProtKB:P35396|UniProtKB:P37238MouseMGI:MGI:6107163|PMID:28683290
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O08785MouseMGI:MGI:3771941|PMID:18075593
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O54943MouseMGI:MGI:5569417|PMID:24413057
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q2VPD4|UniProtKB:Q9WTL8-4MouseMGI:MGI:5918767|PMID:25961797
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q9WTL8MouseMGI:MGI:5700567|PMID:26562092
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q9WTL8-2MouseMGI:MGI:3829113|PMID:18430226
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O08785|UniProtKB:Q9WTL8MouseMGI:MGI:3829113|PMID:18430226
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O08785|UniProtKB:Q9WTL8MouseMGI:MGI:5489023|PMID:23555304
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O08785MouseMGI:MGI:5918767|PMID:25961797
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q62141MouseMGI:MGI:5567917|PMID:15226430
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O08785|UniProtKB:O35973|UniProtKB:O54943|UniProtKB:O70361MouseMGI:MGI:3027197|PMID:14701732
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q8C4V4MouseMGI:MGI:5487698|PMID:23452856
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O88895|UniProtKB:Q9WTL8MouseMGI:MGI:5882311|PMID:26776516
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q8CIG8MouseMGI:MGI:5464222|PMID:23133559
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O54943MouseMGI:MGI:4429726|PMID:20159955
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O54943|UniProtKB:Q9R1X4MouseMGI:MGI:5578016|PMID:23418588
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q8BFZ4MouseMGI:MGI:5470183|PMID:23452855
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:O54943MouseMGI:MGI:5572897|PMID:11889036
Molecular FunctionGO:0005515protein bindingCry1IPIUniProtKB:Q9WTL8MouseMGI:MGI:7327235|PMID:21521686
Molecular FunctionGO:0005515protein bindingcry1aIPIZFIN:ZDB-GENE-011220-2ZfishPMID:19652538
Molecular FunctionGO:0005515protein bindingcry1aIPIUniProtKB:Q8JIG2ZfishPMID:17785416
Molecular FunctionGO:0005515protein bindingcry1aIPIUniProtKB:Q9W6J4ZfishPMID:17785416
Molecular FunctionGO:0005515protein bindingcry1aIPIZFIN:ZDB-GENE-990630-14ZfishPMID:19652538
Molecular FunctionGO:0005515protein bindingcry1aIPIZFIN:ZDB-GENE-000509-1ZfishPMID:19652538
Molecular FunctionGO:0005515protein bindingcry1aIPIUniProtKB:Q8JIG1ZfishPMID:17785416
Molecular FunctionGO:0005515protein bindingcry1aIPIUniProtKB:Q9I879ZfishPMID:17785416
Molecular FunctionGO:0019901protein kinase bindingCry1IPIUniProtKB:Q5EG47|UniProtKB:Q8BRK8MouseMGI:MGI:4366197|PMID:19833968
Molecular FunctionGO:0003712transcription coregulator activitycry1aIDAZfishPMID:29447387
Molecular FunctionGO:0003714transcription corepressor activitycry1aIDAZfishPMID:29447387
Cellular ComponentGO:0005739mitochondrionCry1IDAMouseMGI:MGI:1314997|PMID:9801304
Cellular ComponentGO:0005739mitochondrionCry1HDAMousePMID:18614015
Cellular ComponentGO:0005634nucleusCRY1IDAHumanPMID:26431207
Cellular ComponentGO:0005634nucleusCry1IDAMouseMGI:MGI:5578016|PMID:23418588
Cellular ComponentGO:0005634nucleusCry1IDAMouseMGI:MGI:5567851|PMID:24489120
Cellular ComponentGO:0005634nucleusCry1IDAMouseMGI:MGI:5914352|PMID:28790135
Cellular ComponentGO:0005634nucleusCry1IDAMouseMGI:MGI:5009503|PMID:19129230
Cellular ComponentGO:0005634nucleusCry1IDAMousePMID:12832412
Cellular ComponentGO:0005634nucleusCry1IDAMousePMID:11555636
Cellular ComponentGO:0005634nucleusCry1IDAMousePMID:12150932
Cellular ComponentGO:0005634nucleuscry1aIDAZfishPMID:17785416
Cellular ComponentGO:0005634nucleuscry1bIDAZfishPMID:25630924
Cellular ComponentGO:0005667transcription regulator complexcry1aIPIUniProtKB:Q8JIG1,UniProtKB:Q8JIG3ZfishPMID:12354100
Biological ProcessGO:0032922circadian regulation of gene expressionCry1IMPMouseMGI:MGI:5464222|PMID:23133559
Biological ProcessGO:0032922circadian regulation of gene expressionCry1IMPMouseMGI:MGI:5545849|PMID:24385426
Biological ProcessGO:0032922circadian regulation of gene expressionCry1IGIUniProtKB:P97784MouseMGI:MGI:5302136|PMID:22170608
Biological ProcessGO:0032922circadian regulation of gene expressionCry1IMPMouseMGI:MGI:5490394|PMID:23616524
Biological ProcessGO:0032922circadian regulation of gene expressionCry1IMPMouseMGI:MGI:3843127|PMID:19299583
Biological ProcessGO:0007623circadian rhythmCry1IEPMouseMGI:MGI:5464222|PMID:23133559
Biological ProcessGO:0007623circadian rhythmCry1IMPMouseMGI:MGI:6294193|PMID:29561690
Biological ProcessGO:0007623circadian rhythmCry1IMPMGI:MGI:2181205MousePMID:12024206
Biological ProcessGO:0007623circadian rhythmCry1IDAMousePMID:12843397
Biological ProcessGO:0007623circadian rhythmCry1IMPMousePMID:17264215
Biological ProcessGO:0009649entrainment of circadian clockcry1aIDAZfishPMID:17785416
Biological ProcessGO:0043153entrainment of circadian clock by photoperiodCry1IMPMouseMGI:MGI:5490394|PMID:23616524
Biological ProcessGO:0006094gluconeogenesisCry1IMPMouseMGI:MGI:5567906|PMID:20852621
Biological ProcessGO:0042593glucose homeostasisCry1IGIUniProtKB:P97784MouseMGI:MGI:5302136|PMID:22170608
Biological ProcessGO:0019915lipid storageCry1IGIUniProtKB:Q9R194MouseMGI:MGI:5495865|PMID:23531614
Biological ProcessGO:0042754negative regulation of circadian rhythmCry1IMPMouseMGI:MGI:5532917|PMID:17310242
Biological ProcessGO:0042754negative regulation of circadian rhythmCry1IDAMouseMGI:MGI:4410413|PMID:19605937
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCRY1IDAHumanPMID:12397359
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCRY1IDAHumanPMID:23133559
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IDAMouseMGI:MGI:5292598|PMID:21768648
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IDAMouseMGI:MGI:5545849|PMID:24385426
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IMPMouseMGI:MGI:5913754|PMID:28751364
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IMPMouseMGI:MGI:6107163|PMID:28683290
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IDAMouseMGI:MGI:5582861|PMID:24089055
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IDAMouseMGI:MGI:5574290|PMID:22894897
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IDAMouseMGI:MGI:5553247|PMID:12738229
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IDAMouseMGI:MGI:5532917|PMID:17310242
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IGIUniProtKB:P97784MouseMGI:MGI:5302136|PMID:22170608
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IDAMouseMGI:MGI:5607219|PMID:22208286
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IDAMouseMGI:MGI:4410413|PMID:19605937
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionCry1IDAMouseMGI:MGI:3794495|PMID:18316400
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptioncry1aIDAZfishPMID:25630924
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptioncry1aIDAZfishPMID:12354100
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptioncry1bIDAZfishPMID:25630924
Biological ProcessGO:0045744negative regulation of G protein-coupled receptor signaling pathwayCry1IMPMouseMGI:MGI:5567906|PMID:20852621
Biological ProcessGO:2000323negative regulation of glucocorticoid receptor signaling pathwayCry1IDAMouseMGI:MGI:5567887|PMID:24378737
Biological ProcessGO:2000323negative regulation of glucocorticoid receptor signaling pathwayCry1IGIUniProtKB:P97784MouseMGI:MGI:5302136|PMID:22170608
Biological ProcessGO:2000850negative regulation of glucocorticoid secretionCry1IGIUniProtKB:Q9R194MouseMGI:MGI:5495865|PMID:23531614
Biological ProcessGO:0045721negative regulation of gluconeogenesisCry1IMPMouseMGI:MGI:6208175|PMID:29937374
Biological ProcessGO:0045721negative regulation of gluconeogenesisCry1IMPMouseMGI:MGI:5914352|PMID:28790135
Biological ProcessGO:0031397negative regulation of protein ubiquitinationCry1IDAMouseMGI:MGI:5572897|PMID:11889036
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IICRY1IDAHumanPMID:12397359
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IICRY1IDAHumanPMID:14672706
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IICRY1IDAHumanPMID:15147242
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IICry1IMPMouseMGI:MGI:5567906|PMID:20852621
Biological ProcessGO:0045722positive regulation of gluconeogenesisCry1IDAMouseMGI:MGI:6208175|PMID:29937374
Biological ProcessGO:0031398positive regulation of protein ubiquitinationCry1IMPMouseMGI:MGI:5914352|PMID:28790135
Biological ProcessGO:0042752regulation of circadian rhythmCry1IMPMouseMGI:MGI:5908518|PMID:26431207
Biological ProcessGO:0042752regulation of circadian rhythmCry1IMPMouseMGI:MGI:4947326|PMID:21236481
Biological ProcessGO:0042752regulation of circadian rhythmCry1IMPMouseMGI:MGI:4366197|PMID:19833968
Biological ProcessGO:0042752regulation of circadian rhythmCry1IMPUniProtKB:Q9R194MouseMGI:MGI:5567898|PMID:23575670
Biological ProcessGO:0042752regulation of circadian rhythmCry1IMPMouseMGI:MGI:1334825|PMID:10217146
Biological ProcessGO:0042752regulation of circadian rhythmCry1IMPMouseMGI:MGI:5490394|PMID:23616524
Biological ProcessGO:2000001regulation of DNA damage checkpointCry1IDAMouseMGI:MGI:5567851|PMID:24489120
Biological ProcessGO:0010468regulation of gene expressioncry1bIGIZFIN:ZDB-GENE-030408-1,ZFIN:ZDB-GENE-990630-14ZfishPMID:27171500
Biological ProcessGO:0006111regulation of gluconeogenesisCry1IMPMouseMGI:MGI:6208175|PMID:29937374
Biological ProcessGO:0006111regulation of gluconeogenesisCry1IEPMouseMGI:MGI:6208175|PMID:29937374
Biological ProcessGO:0014823response to activityCry1IMPMouseMGI:MGI:6107163|PMID:28683290
Biological ProcessGO:0033762response to glucagonCry1IMPMouseMGI:MGI:5567906|PMID:20852621
Biological ProcessGO:0042542response to hydrogen peroxidecry1aIEPZfishPMID:17898172
Biological ProcessGO:0032868response to insulinCry1IGIUniProtKB:Q9R194MouseMGI:MGI:5495865|PMID:23531614
Biological ProcessGO:0009416response to light stimulusCry1IMPMouseMGI:MGI:6294193|PMID:29561690
Biological ProcessGO:0009416response to light stimuluscry1aIDAZfishPMID:18800057
Biological ProcessGO:0009416response to light stimuluscry1aIDAZfishPMID:16000406
Biological ProcessGO:0009416response to light stimuluscry1aIDAZfishPMID:19652538
Biological ProcessGO:0009416response to light stimuluscry1aIDAZfishPMID:17785416
Biological ProcessGO:0061912selective autophagyCry1IMPMouseMGI:MGI:6208175|PMID:29937374
Biological ProcessGO:0061912selective autophagyCry1IPIUniProtKB:Q9CQV6MouseMGI:MGI:6208175|PMID:29937374
Biological ProcessGO:0042770signal transduction in response to DNA damageCry1IDAMouseMGI:MGI:5567851|PMID:24489120

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory