Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CRYAB
  • Mouse genes Cryab
  • Rat genes Cryab
  • Zfish genes cryaba,cryabb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cryab

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	CRYAB	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:23106396
Molecular Function	GO:0008092	cytoskeletal protein binding	Cryab	IDA		Rat	PMID:15075233|RGD:1598493
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:12601044
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:16303126
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:18330356
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:19651604
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:20802487
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:21464278
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:22143763
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:22153508
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:23188086
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:24183572
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:26465331
Molecular Function	GO:0042802	identical protein binding	CRYAB	IPI	UniProtKB:P02511	Human	PMID:27226619
Molecular Function	GO:0008017	microtubule binding	Cryab	IDA		Rat	PMID:15075233|RGD:1598493
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P02489	Human	PMID:11700327
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P07315	Human	PMID:11700327
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P00883	Human	PMID:12235146
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P11415	Human	PMID:12235146
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P02489	Human	PMID:12601044
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P04792	Human	PMID:12601044
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P07315	Human	PMID:12601044
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q07812	Human	PMID:14752512
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q07817	Human	PMID:14752512
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P05067	Human	PMID:16049941
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P05813	Human	PMID:17046756
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P04792	Human	PMID:18330356
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P02489	Human	PMID:19651604
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q53QV2	Human	PMID:20587334
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P02489	Human	PMID:22085609
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P02489	Human	PMID:22153508
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P35222	Human	PMID:22158051
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P02489	Human	PMID:23188086
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P04792	Human	PMID:23188086
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q16082	Human	PMID:23188086
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q3UBX0	Human	PMID:23542032
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P22914	Human	PMID:24183572
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P02489	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q16082	Human	PMID:26465331
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P17661	Human	PMID:28470624
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P04792	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P02489	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q3LI64	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q9H8Y8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:O00471	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P09525	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P35222	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:P60891	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q14194	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q6QEF8-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q6UY14-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q8WUY3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CRYAB	IPI	UniProtKB:Q96LI6-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Cryab	IPI	UniProtKB:P42227	Mouse	MGI:MGI:6114831|PMID:27724964
Molecular Function	GO:0005515	protein binding	Cryab	IPI	UniProtKB:P42227	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Cryab	IPI	UniProtKB:P07320	Mouse	MGI:MGI:5508714|PMID:22289178
Molecular Function	GO:0005515	protein binding	Cryab	IPI	PR:P51180	Mouse	PMID:18056999
Molecular Function	GO:0005515	protein binding	Cryab	IPI	PR:P24622	Mouse	PMID:18056999
Molecular Function	GO:0005515	protein binding	Cryab	IPI	UniProtKB:Q9WVJ5	Rat	PMID:19071118|RGD:8553531
Molecular Function	GO:0042803	protein homodimerization activity	CRYAB	IPI	UniProtKB:P02511	Human	PMID:19646995
Molecular Function	GO:0044877	protein-containing complex binding	CRYAB	IPI	ComplexPortal:CPX-1180	Human	PMID:23106396
Molecular Function	GO:0005198	structural molecule activity	CRYAB	IDA		Human	PMID:16303126
Molecular Function	GO:0051082	unfolded protein binding	CRYAB	IPI	UniProtKB:P07315	Human	PMID:16303126
Molecular Function	GO:0051082	unfolded protein binding	cryabb	IDA		Zfish	PMID:16420472
Molecular Function	GO:0051082	unfolded protein binding	cryaba	IDA		Zfish	PMID:15692462
Cellular Component	GO:0032432	actin filament bundle	Cryab	IDA		Rat	PMID:10625651|RGD:1598494
Cellular Component	GO:0030424	axon	Cryab	IDA		Rat	PMID:22617993|RGD:10402750
Cellular Component	GO:0097512	cardiac myofibril	Cryab	IDA		Rat	PMID:9396443|RGD:10402759
Cellular Component	GO:0009986	cell surface	Cryab	IDA		Rat	PMID:17761354|RGD:2303634
Cellular Component	GO:0043292	contractile fiber	Cryab	IDA		Mouse	PMID:14627610
Cellular Component	GO:0005737	cytoplasm	CRYAB	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005737	cytoplasm	CRYAB	IDA		Human	PMID:14752512
Cellular Component	GO:0005737	cytoplasm	CRYAB	IDA		Human	PMID:19464326
Cellular Component	GO:0005737	cytoplasm	CRYAB	IDA		Human	PMID:20587334
Cellular Component	GO:0005829	cytosol	Cryab	IDA		Mouse	PMID:18191123
Cellular Component	GO:0043197	dendritic spine	Cryab	IDA		Rat	PMID:22617993|RGD:10402750
Cellular Component	GO:0070062	extracellular exosome	CRYAB	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CRYAB	HDA		Human	PMID:23533145
Cellular Component	GO:0005794	Golgi apparatus	Cryab	IDA		Rat	PMID:15339919|RGD:1598492
Cellular Component	GO:0031674	I band	Cryab	IDA		Rat	PMID:11945023|RGD:704398
Cellular Component	GO:0031430	M band	Cryab	IDA		Rat	PMID:9396443|RGD:10402759
Cellular Component	GO:0015630	microtubule cytoskeleton	Cryab	IDA		Rat	PMID:15075233|RGD:1598493
Cellular Component	GO:0005739	mitochondrion	Cryab	IDA		Mouse	PMID:18191123
Cellular Component	GO:0043209	myelin sheath	Cryab	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005634	nucleus	CRYAB	IDA		Human	PMID:19464326
Cellular Component	GO:0005634	nucleus	CRYAB	IDA		Human	PMID:20587334
Cellular Component	GO:0005634	nucleus	Cryab	IDA		Rat	PMID:22617993|RGD:10402750
Cellular Component	GO:0043204	perikaryon	Cryab	IDA		Rat	PMID:22617993|RGD:10402750
Cellular Component	GO:0005886	plasma membrane	Cryab	IDA		Mouse	PMID:14627610
Cellular Component	GO:0005886	plasma membrane	cryaba	IDA		Zfish	PMID:18406404
Cellular Component	GO:0014069	postsynaptic density	Cryab	IDA		Rat	PMID:22617993|RGD:10402750
Cellular Component	GO:0032991	protein-containing complex	CRYAB	IDA		Human	PMID:16303126
Cellular Component	GO:0032991	protein-containing complex	CRYAB	IDA		Human	PMID:20587334
Cellular Component	GO:0045202	synapse	Cryab	IDA		Rat	PMID:22617993|RGD:10402750
Cellular Component	GO:0097060	synaptic membrane	Cryab	IDA		Rat	PMID:22617993|RGD:10402750
Cellular Component	GO:0030018	Z disc	Cryab	IDA		Mouse	PMID:14627610
Biological Process	GO:0007568	aging	Cryab	IEP		Rat	PMID:17761354|RGD:2303634
Biological Process	GO:0060561	apoptotic process involved in morphogenesis	Cryab	IGI	MGI:MGI:88515	Mouse	PMID:16439475
Biological Process	GO:0043010	camera-type eye development	Cryab	IGI	MGI:MGI:88515	Mouse	PMID:12546709
Biological Process	GO:0071480	cellular response to gamma radiation	CRYAB	IMP		Human	PMID:23542032
Biological Process	GO:0060047	heart contraction	cryabb	IMP	ZFIN:ZDB-MRPHLNO-150828-2	Zfish	PMID:25866181
Biological Process	GO:0060047	heart contraction	cryaba	IMP	ZFIN:ZDB-MRPHLNO-150828-3	Zfish	PMID:25866181
Biological Process	GO:0002088	lens development in camera-type eye	Cryab	IGI	MGI:MGI:88515	Mouse	PMID:16439475
Biological Process	GO:0007626	locomotory behavior	cryabb	IMP	ZFIN:ZDB-MRPHLNO-150828-2	Zfish	PMID:25866181
Biological Process	GO:0007626	locomotory behavior	cryaba	IMP	ZFIN:ZDB-MRPHLNO-150828-3	Zfish	PMID:25866181
Biological Process	GO:0031109	microtubule polymerization or depolymerization	Cryab	IMP		Rat	PMID:15075233|RGD:1598493
Biological Process	GO:0010259	multicellular organism aging	Cryab	IEP		Rat	PMID:19120020|RGD:13503352
Biological Process	GO:0007517	muscle organ development	Cryab	IGI	MGI:MGI:1916503	Mouse	PMID:11687538
Biological Process	GO:0030239	myofibril assembly	cryabb	IMP	ZFIN:ZDB-MRPHLNO-150828-2	Zfish	PMID:25866181
Biological Process	GO:0030239	myofibril assembly	cryaba	IMP	ZFIN:ZDB-MRPHLNO-150828-3	Zfish	PMID:25866181
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	CRYAB	IDA		Human	PMID:23106396
Biological Process	GO:0043066	negative regulation of apoptotic process	CRYAB	IDA		Human	PMID:14752512
Biological Process	GO:0043066	negative regulation of apoptotic process	Cryab	IMP	MGI:MGI:2652177	Mouse	PMID:18191123
Biological Process	GO:0043066	negative regulation of apoptotic process	Cryab	IDA		Rat	PMID:15358243|RGD:1598485
Biological Process	GO:0030308	negative regulation of cell growth	Cryab	IDA		Rat	PMID:18974385|RGD:2303630
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Cryab	IGI	MGI:MGI:88515	Mouse	PMID:16439475
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	CRYAB	IDA		Human	PMID:20587334
Biological Process	GO:0010629	negative regulation of gene expression	Cryab	IMP	MGI:MGI:2652177	Mouse	PMID:17893660
Biological Process	GO:0032387	negative regulation of intracellular transport	CRYAB	IDA		Human	PMID:14752512
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	CRYAB	IDA		Human	PMID:23106396
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	Cryab	IDA		Rat	PMID:15358243|RGD:1598485
Biological Process	GO:0006457	protein folding	Cryab	IDA		Rat	PMID:18158587|RGD:2303633
Biological Process	GO:0050821	protein stabilization	CRYAB	IMP		Human	PMID:12235146
Biological Process	GO:0010941	regulation of cell death	CRYAB	IMP		Human	PMID:23542032
Biological Process	GO:0032355	response to estradiol	Cryab	IEP		Rat	PMID:17293487|RGD:2303639
Biological Process	GO:0042542	response to hydrogen peroxide	Cryab	IMP	MGI:MGI:2652177	Mouse	PMID:17438522
Biological Process	GO:0042542	response to hydrogen peroxide	Cryab	IEP		Rat	PMID:18420382|RGD:2303631
Biological Process	GO:0001666	response to hypoxia	Cryab	IMP	MGI:MGI:2652177	Mouse	PMID:18191123
Biological Process	GO:0007519	skeletal muscle tissue development	cryabb	IMP	ZFIN:ZDB-MRPHLNO-150828-2	Zfish	PMID:25866181
Biological Process	GO:0007519	skeletal muscle tissue development	cryaba	IMP	ZFIN:ZDB-MRPHLNO-150828-3	Zfish	PMID:25866181
Biological Process	GO:0051403	stress-activated MAPK cascade	Cryab	IMP		Rat	PMID:18420382|RGD:2303631
Biological Process	GO:0007021	tubulin complex assembly	Cryab	IMP	MGI:MGI:2652177	Mouse	PMID:16675842

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern