Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CSK
  • Mouse genes Csk
  • Rat genes Csk
  • Zfish genes csk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Csk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	CSK	IPI	UniProtKB:P41240	Human	PMID:19888460
Molecular Function	GO:0070064	proline-rich region binding	Csk	IPI	UniProtKB:P29352	Rat	PMID:8890164|RGD:8554597
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:P08069	Human	PMID:10026153
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:Q9NWQ8	Human	PMID:10790433
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:P49023	Human	PMID:14665621
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:P00523	Human	PMID:15683240
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:O14745,UniProtKB:P15311,UniProtKB:Q9NWQ8	Human	PMID:17911601
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:O14745,UniProtKB:P17612	Human	PMID:17911601
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:Q9NWQ8	Human	PMID:18070987
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:P00523	Human	PMID:18614016
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:P08575	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:Q6UWF3	Human	PMID:21930792
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:Q7VLE8	Human	PMID:24902122
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:Q9NWQ8	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:P49023	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:Q5T7N3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:Q9NWQ8	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	CSK	IPI	UniProtKB:P08575	Human	PMID:7507203
Molecular Function	GO:0005515	protein binding	Csk	IPI	UniProtKB:Q3UU41	Mouse	MGI:MGI:6317162|PMID:28290451
Molecular Function	GO:0005515	protein binding	Csk	IPI	UniProtKB:P42337	Mouse	MGI:MGI:5825410|PMID:27474268
Molecular Function	GO:0005515	protein binding	Csk	IPI	UniProtKB:Q3U1F9	Mouse	MGI:MGI:5825414|PMID:26512138
Molecular Function	GO:0005515	protein binding	Csk	IPI	UniProtKB:Q3U1F9	Mouse	MGI:MGI:3687921|PMID:12612075
Molecular Function	GO:0005515	protein binding	Csk	IPI	PR:Q3UHC2	Mouse	PMID:23526378
Molecular Function	GO:0005515	protein binding	Csk	IPI	PR:P55284	Mouse	PMID:15861137
Molecular Function	GO:0005515	protein binding	Csk	IPI	UniProtKB:D3ZMK9	Rat	PMID:21873224|RGD:11556156
Molecular Function	GO:0005515	protein binding	Csk	IPI	UniProtKB:D3ZMK9	Rat	PMID:27116701|RGD:13514074
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	CSK	IPI	UniProtKB:P17612	Human	PMID:17911601
Molecular Function	GO:0019903	protein phosphatase binding	Csk	IPI	RGD:1307992	Rat	PMID:25505293|RGD:9835029
Molecular Function	GO:0019903	protein phosphatase binding	Csk	IPI	UniProtKB:P29352	Rat	PMID:8890164|RGD:8554597
Molecular Function	GO:0004713	protein tyrosine kinase activity	Csk	IDA		Rat	PMID:7683130|RGD:5134374
Molecular Function	GO:1990782	protein tyrosine kinase binding	Csk	IPI	RGD:1306273	Rat	PMID:12700184|RGD:2291909
Cellular Component	GO:0005911	cell-cell junction	Csk	IDA		Mouse	PMID:15861137
Cellular Component	GO:0005737	cytoplasm	Csk	IDA		Rat	PMID:10411542|RGD:5134371
Cellular Component	GO:0005737	cytoplasm	Csk	IDA		Rat	PMID:21873224|RGD:11556156
Cellular Component	GO:0070062	extracellular exosome	CSK	HDA		Human	PMID:19056867
Cellular Component	GO:0045121	membrane raft	Csk	IDA		Rat	PMID:15322113|RGD:1581137
Cellular Component	GO:0005886	plasma membrane	CSK	IPI	UniProtKB:Q9NWQ8	Human	PMID:10790433
Biological Process	GO:0034332	adherens junction organization	Csk	IEP		Rat	PMID:15389520|RGD:5134367
Biological Process	GO:0007420	brain development	Csk	IEP		Rat	PMID:7529760|RGD:5134373
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Csk	IDA		Rat	PMID:17071733|RGD:5134364
Biological Process	GO:0060027	convergent extension involved in gastrulation	csk	IMP	ZFIN:ZDB-MRPHLNO-070304-1	Zfish	PMID:17157484
Biological Process	GO:0045779	negative regulation of bone resorption	Csk	IDA		Rat	PMID:10411542|RGD:5134371
Biological Process	GO:0008285	negative regulation of cell population proliferation	Csk	IMP		Mouse	PMID:15861137
Biological Process	GO:0008285	negative regulation of cell population proliferation	Csk	IGI	MGI:MGI:105057	Mouse	PMID:15861137
Biological Process	GO:0008285	negative regulation of cell population proliferation	Csk	IDA		Rat	PMID:10411542|RGD:5134371
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Csk	IDA		Rat	PMID:9325302|RGD:2303720
Biological Process	GO:0042997	negative regulation of Golgi to plasma membrane protein transport	CSK	IDA		Human	PMID:20605918
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Csk	IDA		Rat	PMID:10411542|RGD:5134371
Biological Process	GO:0033673	negative regulation of kinase activity	Csk	IDA		Rat	PMID:10411542|RGD:5134371
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	Csk	IDA		Rat	PMID:10884975|RGD:5134370
Biological Process	GO:0050765	negative regulation of phagocytosis	Csk	IDA		Rat	PMID:10884975|RGD:5134370
Biological Process	GO:0048709	oligodendrocyte differentiation	Csk	IEP		Rat	PMID:15504915|RGD:2303714
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Csk	IDA		Rat	PMID:10884975|RGD:5134370
Biological Process	GO:0046777	protein autophosphorylation	Csk	IDA		Rat	PMID:7683130|RGD:5134374
Biological Process	GO:0006468	protein phosphorylation	Csk	IDA		Rat	PMID:7683130|RGD:5134374
Biological Process	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	Csk	IDA		Rat	PMID:9325302|RGD:2303720

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern