Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CST3
  • Mouse genes Cst3
  • Rat genes Cst3
  • Zfish genes cst3,zgc:163030
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cst3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	CST3	IPI	UniProtKB:P05067	Human	PMID:18026102
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	CST3	IDA		Human	PMID:3488317
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	CST3	IDA		Human	PMID:6203523
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	CST3	IDA		Human	PMID:7890620
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	CST3	IDA		Human	PMID:8999869
Molecular Function	GO:0004866	endopeptidase inhibitor activity	CST3	IDA		Human	PMID:15127951
Molecular Function	GO:0042802	identical protein binding	CST3	IPI	UniProtKB:P01034	Human	PMID:25479090
Molecular Function	GO:0042802	identical protein binding	CST3	IPI	UniProtKB:P01034	Human	PMID:26865059
Molecular Function	GO:0030414	peptidase inhibitor activity	CST3	IDA		Human	PMID:18256700
Molecular Function	GO:0030414	peptidase inhibitor activity	Cst3	IDA		Rat	PMID:8761177|RGD:2306519
Molecular Function	GO:0002020	protease binding	CST3	IPI	UniProtKB:P07858	Human	PMID:6203523
Molecular Function	GO:0002020	protease binding	CST3	IPI	UniProtKB:P09668	Human	PMID:6203523
Molecular Function	GO:0002020	protease binding	CST3	IPI	UniProtKB:P07858	Human	PMID:7890620
Molecular Function	GO:0002020	protease binding	Cst3	IDA		Rat	PMID:2622871|RGD:2306525
Molecular Function	GO:0002020	protease binding	Cst3	IDA		Rat	PMID:8761177|RGD:2306519
Molecular Function	GO:0005515	protein binding	CST3	IPI	UniProtKB:P09668	Human	PMID:15127951
Molecular Function	GO:0005515	protein binding	CST3	IPI	UniProtKB:P98158	Human	PMID:17462596
Molecular Function	GO:0005515	protein binding	CST3	IPI	UniProtKB:P05067	Human	PMID:32814053
Cellular Component	GO:0030424	axon	Cst3	IDA		Rat	PMID:14738488|RGD:2306513
Cellular Component	GO:0005604	basement membrane	Cst3	IDA		Rat	PMID:15872057|RGD:2306505
Cellular Component	GO:0042995	cell projection	Cst3	IDA		Rat	PMID:16309830|RGD:2306503
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Cst3	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0043292	contractile fiber	Cst3	IDA		Rat	PMID:8245434|RGD:2306522
Cellular Component	GO:0005737	cytoplasm	Cst3	IDA		Rat	PMID:16414118|RGD:2306496
Cellular Component	GO:0005783	endoplasmic reticulum	Cst3	IDA		Rat	PMID:15872057|RGD:2306505
Cellular Component	GO:0070062	extracellular exosome	CST3	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	CST3	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	CST3	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	CST3	IMP		Human	PMID:18026102
Cellular Component	GO:0005615	extracellular space	CST3	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	CST3	IDA		Human	PMID:18613859
Cellular Component	GO:0005615	extracellular space	CST3	IDA		Human	PMID:28904096
Cellular Component	GO:0005615	extracellular space	CST3	IDA		Human	PMID:3488317
Cellular Component	GO:0005615	extracellular space	Cst3	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Cst3	IDA		Rat	PMID:2689174|RGD:728248
Cellular Component	GO:0005794	Golgi apparatus	CST3	IDA		Human	PMID:15212960
Cellular Component	GO:0005764	lysosome	Cst3	IDA		Rat	PMID:9222450|RGD:2306518
Cellular Component	GO:0005771	multivesicular body	Cst3	IDA		Rat	PMID:10950881|RGD:2306514
Cellular Component	GO:0043025	neuronal cell body	Cst3	IDA		Rat	PMID:14738488|RGD:2306513
Cellular Component	GO:0031965	nuclear membrane	Cst3	IDA		Rat	PMID:15872057|RGD:2306505
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Cst3	IDA		Rat	PMID:16414118|RGD:2306496
Cellular Component	GO:0005886	plasma membrane	CST3	IDA		Human	PMID:22365146
Cellular Component	GO:0031982	vesicle	Cst3	IDA		Rat	PMID:10950881|RGD:2306514
Biological Process	GO:0006915	apoptotic process	Cst3	IEP		Rat	PMID:16414118|RGD:2306496
Biological Process	GO:0007420	brain development	Cst3	IEP		Rat	PMID:2471663|RGD:2306524
Biological Process	GO:0001775	cell activation	Cst3	IEP		Rat	PMID:16521186|RGD:2306500
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Cst3	IEP		Rat	PMID:17440810|RGD:2306497
Biological Process	GO:0034599	cellular response to oxidative stress	Cst3	IEP		Rat	PMID:10930551|RGD:2306502
Biological Process	GO:0034599	cellular response to oxidative stress	Cst3	IMP		Rat	PMID:16140167|RGD:1578437
Biological Process	GO:0042747	circadian sleep/wake cycle, REM sleep	Cst3	IEP		Rat	PMID:17027151|RGD:2306498
Biological Process	GO:0006952	defense response	CST3	IDA		Human	PMID:6203523
Biological Process	GO:0007566	embryo implantation	Cst3	IEP		Rat	PMID:16935259|RGD:2306499
Biological Process	GO:0001654	eye development	Cst3	IEP		Rat	PMID:11431459|RGD:2306512
Biological Process	GO:0008584	male gonad development	Cst3	IEP		Rat	PMID:8286570|RGD:2306523
Biological Process	GO:0060313	negative regulation of blood vessel remodeling	CST3	IMP		Human	PMID:10545518
Biological Process	GO:0010711	negative regulation of collagen catabolic process	CST3	IMP		Human	PMID:10545518
Biological Process	GO:0060311	negative regulation of elastin catabolic process	CST3	IMP		Human	PMID:10545518
Biological Process	GO:0010716	negative regulation of extracellular matrix disassembly	CST3	IMP		Human	PMID:10545518
Biological Process	GO:0010466	negative regulation of peptidase activity	CST3	IDA		Human	PMID:18256700
Biological Process	GO:0010466	negative regulation of peptidase activity	CST3	IDA		Human	PMID:6203523
Biological Process	GO:0010466	negative regulation of peptidase activity	CST3	IDA		Human	PMID:7890620
Biological Process	GO:0045861	negative regulation of proteolysis	CST3	IDA		Human	PMID:3488317
Biological Process	GO:0008284	positive regulation of cell population proliferation	Cst3	IDA		Rat	PMID:11144350|RGD:2306506
Biological Process	GO:0008284	positive regulation of cell population proliferation	Cst3	IDA		Rat	PMID:1540157|RGD:2306501
Biological Process	GO:0045740	positive regulation of DNA replication	Cst3	IDA		Rat	PMID:1540157|RGD:2306501
Biological Process	GO:0034103	regulation of tissue remodeling	CST3	IMP		Human	PMID:10545518
Biological Process	GO:0048678	response to axon injury	Cst3	IEP		Rat	PMID:12044447|RGD:2306510
Biological Process	GO:0048678	response to axon injury	Cst3	IEP		Rat	PMID:14745560|RGD:2306507
Biological Process	GO:0048678	response to axon injury	Cst3	IEP		Rat	PMID:8738161|RGD:2306509
Biological Process	GO:0048678	response to axon injury	Cst3	IEP		Rat	PMID:9147287|RGD:2306508
Biological Process	GO:0009743	response to carbohydrate	Cst3	IEP		Rat	PMID:11246163|RGD:2306511
Biological Process	GO:0009743	response to carbohydrate	Cst3	IEP		Rat	PMID:9222450|RGD:2306518
Biological Process	GO:0032355	response to estradiol	Cst3	IEP		Rat	PMID:16935259|RGD:2306499
Biological Process	GO:0001666	response to hypoxia	Cst3	IEP		Rat	PMID:8590041|RGD:2306520
Biological Process	GO:0010035	response to inorganic substance	Cst3	IEP		Rat	PMID:7747285|RGD:2306521
Biological Process	GO:0031667	response to nutrient levels	Cst3	IEP		Rat	PMID:18723004|RGD:2301196
Biological Process	GO:0014070	response to organic cyclic compound	Cst3	IEP		Rat	PMID:2757396|RGD:1299644
Biological Process	GO:0009636	response to toxic substance	Cst3	IEP		Rat	PMID:16414118|RGD:2306496
Biological Process	GO:0009410	response to xenobiotic stimulus	Cst3	IEP		Rat	PMID:16248890|RGD:2306504
Biological Process	GO:0007431	salivary gland development	Cst3	IEP		Rat	PMID:10075146|RGD:2306516
Biological Process	GO:0060009	Sertoli cell development	Cst3	IEP		Rat	PMID:9432134|RGD:2306517
Biological Process	GO:0097435	supramolecular fiber organization	CST3	IGI		Human	PMID:18026102

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern