Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTCF
  • Mouse genes Ctcf
  • Rat genes Ctcf
  • Zfish genes ctcf
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctcf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Ctcf	IDA		Mouse	PMID:23804403
Molecular Function	GO:0003682	chromatin binding	Ctcf	IDA		Mouse	PMID:22780989
Molecular Function	GO:0003682	chromatin binding	Ctcf	IDA		Mouse	PMID:24105743
Molecular Function	GO:0003682	chromatin binding	ctcf	IDA		Zfish	PMID:24321385
Molecular Function	GO:0043035	chromatin insulator sequence binding	CTCF	IDA		Human	PMID:17827499
Molecular Function	GO:0003677	DNA binding	Ctcf	IDA		Mouse	PMID:15340049
Molecular Function	GO:0003677	DNA binding	Ctcf	IDA		Mouse	PMID:12461525
Molecular Function	GO:0003677	DNA binding	Ctcf	IDA		Mouse	PMID:15143173
Molecular Function	GO:0003677	DNA binding	Ctcf	IDA		Mouse	PMID:11743158
Molecular Function	GO:0003700	DNA-binding transcription factor activity	CTCF	IDA		Human	PMID:8649389
Molecular Function	GO:0003700	DNA-binding transcription factor activity	CTCF	IDA		Human	PMID:9591631
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Ctcf	IDA		Rat	PMID:15352122|RGD:1342455
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	CTCF	IDA		Human	PMID:8649389
Molecular Function	GO:0005515	protein binding	CTCF	IPI	UniProtKB:Q01664	Human	PMID:19505873
Molecular Function	GO:0005515	protein binding	CTCF	IPI	UniProtKB:Q01860	Human	PMID:19536159
Molecular Function	GO:0005515	protein binding	CTCF	IPI	UniProtKB:Q00341	Human	PMID:24725430
Molecular Function	GO:0005515	protein binding	CTCF	IPI	UniProtKB:Q9UGL1	Human	PMID:24937458
Molecular Function	GO:0005515	protein binding	CTCF	IPI	UniProtKB:Q5VZL5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTCF	IPI	UniProtKB:Q02224	Human	PMID:26321640
Molecular Function	GO:0005515	protein binding	CTCF	IPI	UniProtKB:O95789-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTCF	IPI	UniProtKB:Q12933	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTCF	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Ctcf	IPI	UniProtKB:Q09XV5	Mouse	MGI:MGI:3663239|PMID:16949368
Molecular Function	GO:0005515	protein binding	Ctcf	IPI	UniProtKB:Q9D945	Mouse	MGI:MGI:5796065|PMID:26961175
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	CTCF	IDA		Human	PMID:8649389
Molecular Function	GO:0043565	sequence-specific DNA binding	CTCF	IDA		Human	PMID:17827499
Molecular Function	GO:0043565	sequence-specific DNA binding	Ctcf	IDA		Mouse	PMID:12075007
Molecular Function	GO:0000976	transcription cis-regulatory region binding	CTCF	IDA		Human	PMID:18413740
Molecular Function	GO:0001221	transcription coregulator binding	CTCF	IPI	UniProtKB:Q9UFW8	Human	PMID:31547883
Cellular Component	GO:0000775	chromosome, centromeric region	CTCF	IDA		Human	PMID:18550811
Cellular Component	GO:0000775	chromosome, centromeric region	CTCF	IDA		Human	PMID:26321640
Cellular Component	GO:0000793	condensed chromosome	CTCF	IDA		Human	PMID:16107875
Cellular Component	GO:0001651	dense fibrillar component	Ctcf	IDA		Rat	PMID:16595548|RGD:151356507
Cellular Component	GO:0001652	granular component	Ctcf	IDA		Rat	PMID:16595548|RGD:151356507
Cellular Component	GO:0001673	male germ cell nucleus	Ctcf	IDA		Mouse	PMID:12011441
Cellular Component	GO:0005730	nucleolus	CTCF	IDA		Human	PMID:16595548
Cellular Component	GO:0005654	nucleoplasm	CTCF	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CTCF	IDA		Human	PMID:16107875
Cellular Component	GO:0005654	nucleoplasm	CTCF	IDA		Human	PMID:16595548
Cellular Component	GO:0005634	nucleus	CTCF	IDA		Human	PMID:28319062
Cellular Component	GO:0005634	nucleus	CTCF	IDA		Human	PMID:31547883
Cellular Component	GO:0005634	nucleus	CTCF	IDA		Human	PMID:9407128
Cellular Component	GO:0005634	nucleus	Ctcf	IDA		Mouse	PMID:15572351
Cellular Component	GO:0005634	nucleus	Ctcf	IDA		Mouse	PMID:12075007
Biological Process	GO:0140588	chromatin looping	CTCF	IDA		Human	PMID:18654629
Biological Process	GO:0140588	chromatin looping	Ctcf	IMP		Mouse	MGI:MGI:3655597|PMID:16951251
Biological Process	GO:0006306	DNA methylation	Ctcf	IDA		Mouse	PMID:12461525
Biological Process	GO:0006306	DNA methylation	Ctcf	IMP		Mouse	PMID:24105743
Biological Process	GO:0040029	epigenetic regulation of gene expression	CTCF	IMP		Human	PMID:16815976
Biological Process	GO:0071514	genomic imprinting	CTCF	IDA		Human	PMID:17827499
Biological Process	GO:0008285	negative regulation of cell population proliferation	CTCF	IMP		Human	PMID:28319062
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	CTCF	IDA		Human	PMID:18413740
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	CTCF	IDA		Human	PMID:8649389
Biological Process	GO:0010629	negative regulation of gene expression	Ctcf	IMP		Mouse	MGI:MGI:3852297|PMID:18614575
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	Ctcf	IMP		Mouse	PMID:14716017
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	CTCF	IDA		Human	PMID:8649389
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Ctcf	IMP		Mouse	PMID:24105743
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CTCF	IMP		Human	PMID:19322193
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	CTCF	IDA		Human	PMID:9407128
Biological Process	GO:0010628	positive regulation of gene expression	CTCF	IMP		Human	PMID:18347100
Biological Process	GO:0010628	positive regulation of gene expression	Ctcf	IMP		Mouse	MGI:MGI:3852297|PMID:18614575
Biological Process	GO:1902895	positive regulation of miRNA transcription	Ctcf	IMP		Rat	PMID:27124358|RGD:11344932
Biological Process	GO:0071459	protein localization to chromosome, centromeric region	CTCF	IMP		Human	PMID:26321640
Biological Process	GO:0006355	regulation of DNA-templated transcription	Ctcf	IDA		Mouse	PMID:15143173
Biological Process	GO:0010468	regulation of gene expression	ctcf	IDA		Zfish	PMID:24321385
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	Ctcf	IDA		Mouse	PMID:15143173
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	Ctcf	IDA		Mouse	PMID:12461525
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	Ctcf	IMP		Mouse	PMID:14716017
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ctcf	IMP	ZFIN:ZDB-MRPHLNO-120518-1	Zfish	PMID:21556064
Biological Process	GO:0007519	skeletal muscle tissue development	ctcf	IMP	ZFIN:ZDB-MRPHLNO-110420-1	Zfish	PMID:21288905
Biological Process	GO:0007519	skeletal muscle tissue development	ctcf	IMP	ZFIN:ZDB-MRPHLNO-110420-2	Zfish	PMID:21288905

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern