Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTH
  • Mouse genes Cth
  • Rat genes Cth
  • Zfish genes cth,cthl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cth

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004121	cystathionine beta-lyase activity	Cth	IDA		Rat	PMID:9359866|RGD:1359024
Molecular Function	GO:0004123	cystathionine gamma-lyase activity	CTH	IDA		Human	PMID:10212249
Molecular Function	GO:0004123	cystathionine gamma-lyase activity	CTH	IDA		Human	PMID:19019829
Molecular Function	GO:0004123	cystathionine gamma-lyase activity	CTH	IDA		Human	PMID:19428278
Molecular Function	GO:0004123	cystathionine gamma-lyase activity	Cth	IDA		Mouse	PMID:15038791
Molecular Function	GO:0042802	identical protein binding	CTH	IPI	UniProtKB:P32929	Human	PMID:16189514
Molecular Function	GO:0042802	identical protein binding	CTH	IPI	UniProtKB:P32929	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	CTH	IPI	UniProtKB:P32929	Human	PMID:32296183
Molecular Function	GO:0044540	L-cystine L-cysteine-lyase (deaminating)	CTH	IMP		Human	PMID:22169477
Molecular Function	GO:0044540	L-cystine L-cysteine-lyase (deaminating)	Cth	IDA		Mouse	MGI:MGI:5304595|PMID:22244329
Molecular Function	GO:0044540	L-cystine L-cysteine-lyase (deaminating)	Cth	IMP		Mouse	MGI:MGI:5315686|PMID:19903941
Molecular Function	GO:0005515	protein binding	CTH	IPI	UniProtKB:P18031	Human	PMID:22169477
Molecular Function	GO:0005515	protein binding	CTH	IPI	UniProtKB:Q6P9E2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTH	IPI	UniProtKB:Q96HA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTH	IPI	UniProtKB:Q96NT3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTH	IPI	UniProtKB:Q6P9E2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTH	IPI	UniProtKB:Q96NT3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Cth	IPI	UniProtKB:P16858	Mouse	MGI:MGI:5315686|PMID:19903941
Molecular Function	GO:0005515	protein binding	Cth	IPI	UniProtKB:Q04207	Mouse	MGI:MGI:5304595|PMID:22244329
Molecular Function	GO:0030170	pyridoxal phosphate binding	CTH	IDA		Human	PMID:10212249
Molecular Function	GO:0030170	pyridoxal phosphate binding	CTH	IDA		Human	PMID:19019829
Cellular Component	GO:0070062	extracellular exosome	CTH	HDA		Human	PMID:19056867
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Cth	IEP		Mouse	PMID:20439489
Biological Process	GO:0019344	cysteine biosynthetic process	CTH	IDA		Human	PMID:10212249
Biological Process	GO:0019344	cysteine biosynthetic process	Cth	IDA		Rat	PMID:9359866|RGD:1359024
Biological Process	GO:0019343	cysteine biosynthetic process via cystathionine	CTH	IDA		Human	PMID:19428278
Biological Process	GO:0006749	glutathione metabolic process	Cth	IMP		Rat	PMID:15683713|RGD:1600763
Biological Process	GO:0050667	homocysteine metabolic process	Cth	IDA		Rat	PMID:9359866|RGD:1359024
Biological Process	GO:0070814	hydrogen sulfide biosynthetic process	CTH	IDA		Human	PMID:19019829
Biological Process	GO:0043066	negative regulation of apoptotic process	Cth	IMP		Mouse	MGI:MGI:5304595|PMID:22244329
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	Cth	IMP		Mouse	PMID:22244329
Biological Process	GO:0030308	negative regulation of cell growth	Cth	IMP		Rat	PMID:15347670|RGD:1600762
Biological Process	GO:0008285	negative regulation of cell population proliferation	Cth	IMP		Rat	PMID:15347670|RGD:1600762
Biological Process	GO:1904831	positive regulation of aortic smooth muscle cell differentiation	CTH	IMP		Human	PMID:21659522
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Cth	IMP		Mouse	MGI:MGI:5304595|PMID:22244329
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Cth	IMP		Mouse	MGI:MGI:5304595|PMID:22244329
Biological Process	GO:0051289	protein homotetramerization	CTH	IPI	UniProtKB:P32929	Human	PMID:19019829
Biological Process	GO:0044524	protein sulfhydration	CTH	IMP		Human	PMID:22169477
Biological Process	GO:0044524	protein sulfhydration	Cth	IDA		Mouse	MGI:MGI:5304595|PMID:22244329
Biological Process	GO:0044524	protein sulfhydration	Cth	IMP		Mouse	MGI:MGI:5315686|PMID:19903941
Biological Process	GO:0018272	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	CTH	IDA		Human	PMID:19019829
Biological Process	GO:0019346	transsulfuration	CTH	IDA		Human	PMID:19428278

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern