Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTHRC1
  • Mouse genes Cthrc1
  • Rat genes Cthrc1
  • Zfish genes cthrc1a,cthrc1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cthrc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	Cthrc1	IPI	PR:Q61089	Mouse	PMID:18606138
Molecular Function	GO:0005109	frizzled binding	Cthrc1	IPI	PR:Q61086	Mouse	PMID:18606138
Molecular Function	GO:0005109	frizzled binding	Cthrc1	IPI	PR:Q9EQD0	Mouse	PMID:18606138
Molecular Function	GO:0005515	protein binding	Cthrc1	IPI	PR:Q9Z138	Mouse	PMID:18606138
Molecular Function	GO:0017147	Wnt-protein binding	Cthrc1	IPI	PR:P22725	Mouse	PMID:18606138
Molecular Function	GO:0017147	Wnt-protein binding	Cthrc1	IPI	PR:P48615	Mouse	PMID:18606138
Molecular Function	GO:0017147	Wnt-protein binding	Cthrc1	IPI	PR:P27467	Mouse	PMID:18606138
Cellular Component	GO:0062023	collagen-containing extracellular matrix	CTHRC1	HDA		Human	PMID:28675934
Cellular Component	GO:0031012	extracellular matrix	Cthrc1	IDA		Rat	PMID:15618538|RGD:1547887
Cellular Component	GO:0005576	extracellular region	CTHRC1	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	CTHRC1	IDA		Human	PMID:18467647
Cellular Component	GO:0005615	extracellular space	CTHRC1	IDA		Human	PMID:23056600
Cellular Component	GO:0005615	extracellular space	Cthrc1	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0016528	sarcoplasm	Cthrc1	IDA		Mouse	PMID:18467647
Biological Process	GO:0007155	cell adhesion	cthrc1a	IMP	ZFIN:ZDB-MRPHLNO-191101-1	Zfish	PMID:31077712
Biological Process	GO:0016477	cell migration	Cthrc1	IMP		Rat	PMID:15618538|RGD:1547887
Biological Process	GO:0042074	cell migration involved in gastrulation	cthrc1a	IMP	ZFIN:ZDB-MRPHLNO-191101-1	Zfish	PMID:31077712
Biological Process	GO:0090103	cochlea morphogenesis	Cthrc1	IGI	MGI:MGI:1915838	Mouse	PMID:18606138
Biological Process	GO:0060028	convergent extension involved in axis elongation	cthrc1a	IMP	ZFIN:ZDB-MRPHLNO-191101-2	Zfish	PMID:31077712
Biological Process	GO:0060028	convergent extension involved in axis elongation	cthrc1a	IMP	ZFIN:ZDB-MRPHLNO-191101-1	Zfish	PMID:31077712
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	cthrc1a	IMP	ZFIN:ZDB-MRPHLNO-191101-2	Zfish	PMID:31077712
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	cthrc1a	IMP	ZFIN:ZDB-MRPHLNO-191101-1	Zfish	PMID:31077712
Biological Process	GO:0090177	establishment of planar polarity involved in neural tube closure	Cthrc1	IGI	MGI:MGI:1915838	Mouse	PMID:18606138
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	Cthrc1	IGI	MGI:MGI:1915838	Mouse	PMID:18606138
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Cthrc1	IDA		Mouse	PMID:18606138
Biological Process	GO:0043932	ossification involved in bone remodeling	Cthrc1	IMP	MGI:MGI:3830252	Mouse	PMID:18779865
Biological Process	GO:0001649	osteoblast differentiation	Cthrc1	IMP	MGI:MGI:3830252	Mouse	PMID:18779865
Biological Process	GO:0033687	osteoblast proliferation	Cthrc1	IMP	MGI:MGI:3830252	Mouse	PMID:18779865
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Cthrc1	IMP	MGI:MGI:3830252	Mouse	PMID:18779865
Biological Process	GO:0033690	positive regulation of osteoblast proliferation	Cthrc1	IMP	MGI:MGI:3830252	Mouse	PMID:18779865
Biological Process	GO:0032092	positive regulation of protein binding	Cthrc1	IDA		Mouse	PMID:18606138
Biological Process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Cthrc1	IMP	MGI:MGI:3815067	Mouse	PMID:18606138

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern