Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTNS
  • Mouse genes Ctns
  • Rat genes Ctns
  • Zfish genes ctns
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctns

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015184	L-cystine transmembrane transporter activity	CTNS	IDA		Human	PMID:11689434
Molecular Function	GO:0015184	L-cystine transmembrane transporter activity	CTNS	IDA		Human	PMID:15128704
Molecular Function	GO:0015184	L-cystine transmembrane transporter activity	CTNS	IMP		Human	PMID:15128704
Molecular Function	GO:0015184	L-cystine transmembrane transporter activity	CTNS	IDA		Human	PMID:22232659
Molecular Function	GO:0015184	L-cystine transmembrane transporter activity	Ctns	IMP	MGI:MGI:2388945	Mouse	PMID:12370309
Molecular Function	GO:0015184	L-cystine transmembrane transporter activity	Ctns	IMP	MGI:MGI:2388945	Mouse	PMID:17977621
Molecular Function	GO:0015184	L-cystine transmembrane transporter activity	Ctns	IDA		Mouse	PMID:12370309
Molecular Function	GO:0015295	solute:proton symporter activity	CTNS	IDA		Human	PMID:11689434
Molecular Function	GO:0015295	solute:proton symporter activity	CTNS	IDA		Human	PMID:22232659
Cellular Component	GO:0070062	extracellular exosome	CTNS	HDA		Human	PMID:19056867
Cellular Component	GO:0045111	intermediate filament cytoskeleton	CTNS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	CTNS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005770	late endosome	CTNS	IDA		Human	PMID:15128704
Cellular Component	GO:0005765	lysosomal membrane	CTNS	IDA		Human	PMID:11150305
Cellular Component	GO:0005765	lysosomal membrane	CTNS	IDA		Human	PMID:11689434
Cellular Component	GO:0005765	lysosomal membrane	CTNS	IDA		Human	PMID:15128704
Cellular Component	GO:0005765	lysosomal membrane	CTNS	HDA		Human	PMID:17897319
Cellular Component	GO:0005764	lysosome	CTNS	IDA		Human	PMID:11855931
Cellular Component	GO:0005764	lysosome	CTNS	IDA		Human	PMID:12138135
Cellular Component	GO:0005764	lysosome	CTNS	IDA		Human	PMID:15128704
Cellular Component	GO:0005764	lysosome	Ctns	IDA		Mouse	PMID:12370309
Cellular Component	GO:0042470	melanosome	CTNS	IDA		Human	PMID:22649030
Biological Process	GO:0007628	adult walking behavior	Ctns	IMP	MGI:MGI:2388945	Mouse	PMID:17977621
Biological Process	GO:0046034	ATP metabolic process	CTNS	IMP		Human	PMID:16439594
Biological Process	GO:0007420	brain development	CTNS	IMP		Human	PMID:17471495
Biological Process	GO:1904970	brush border assembly	Ctns	IMP		Rat	PMID:35695380|RGD:155630629
Biological Process	GO:0050890	cognition	CTNS	IMP		Human	PMID:17471495
Biological Process	GO:0003094	glomerular filtration	ctns	IMP	ZFIN:ZDB-GENO-181024-2	Zfish	PMID:28198397
Biological Process	GO:0006749	glutathione metabolic process	CTNS	IMP		Human	PMID:15956064
Biological Process	GO:0007625	grooming behavior	Ctns	IMP	MGI:MGI:2388945	Mouse	PMID:17977621
Biological Process	GO:1902475	L-alpha-amino acid transmembrane transport	Ctns	IMP	MGI:MGI:2388945	Mouse	MGI:MGI:3848688|PMID:17977621
Biological Process	GO:0015811	L-cystine transport	CTNS	IDA		Human	PMID:11689434
Biological Process	GO:0015811	L-cystine transport	CTNS	IDA		Human	PMID:15128704
Biological Process	GO:0015811	L-cystine transport	CTNS	IMP		Human	PMID:15128704
Biological Process	GO:0015811	L-cystine transport	CTNS	IDA		Human	PMID:22232659
Biological Process	GO:0015811	L-cystine transport	CTNS	IMP		Human	PMID:7112129
Biological Process	GO:0015811	L-cystine transport	Ctns	IMP	MGI:MGI:2388945	Mouse	PMID:21897743
Biological Process	GO:0015811	L-cystine transport	Ctns	IMP	MGI:MGI:2388945	Mouse	PMID:17977621
Biological Process	GO:0015811	L-cystine transport	Ctns	IMP	MGI:MGI:2388945	Mouse	PMID:12370309
Biological Process	GO:0015811	L-cystine transport	Ctns	IDA		Mouse	PMID:12370309
Biological Process	GO:0015811	L-cystine transport	Ctns	IMP		Rat	PMID:26482480|RGD:12910938
Biological Process	GO:0002088	lens development in camera-type eye	Ctns	IMP	MGI:MGI:2388945	Mouse	PMID:21897743
Biological Process	GO:0007616	long-term memory	Ctns	IMP	MGI:MGI:2388945	Mouse	PMID:17977621
Biological Process	GO:0043066	negative regulation of apoptotic process	Ctns	IMP		Rat	PMID:35695380|RGD:155630629
Biological Process	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	Ctns	IMP		Rat	PMID:26482480|RGD:12910938
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	Ctns	IMP		Rat	PMID:26482480|RGD:12910938
Biological Process	GO:0010918	positive regulation of mitochondrial membrane potential	Ctns	IMP		Rat	PMID:26482480|RGD:12910938
Biological Process	GO:2000611	positive regulation of thyroid hormone generation	Ctns	IMP		Rat	PMID:35695380|RGD:155630629
Biological Process	GO:1904263	positive regulation of TORC1 signaling	Ctns	IMP		Mouse	MGI:MGI:6508509|PMID:26449607
Biological Process	GO:0072158	proximal tubule morphogenesis	Ctns	IMP		Rat	PMID:35695380|RGD:155630629
Biological Process	GO:0010506	regulation of autophagy	ctns	IMP	ZFIN:ZDB-GENO-190812-41	Zfish	PMID:29323117
Biological Process	GO:0048021	regulation of melanin biosynthetic process	CTNS	IMP		Human	PMID:22649030
Biological Process	GO:0070293	renal absorption	ctns	IMP	ZFIN:ZDB-GENO-181024-2	Zfish	PMID:28198397
Biological Process	GO:0097018	renal albumin absorption	Ctns	IMP		Rat	PMID:35695380|RGD:155630629
Biological Process	GO:0035623	renal glucose absorption	Ctns	IMP		Rat	PMID:35695380|RGD:155630629
Biological Process	GO:0097291	renal phosphate ion absorption	Ctns	IMP		Rat	PMID:35695380|RGD:155630629
Biological Process	GO:0070295	renal water absorption	Ctns	IMP		Rat	PMID:35695380|RGD:155630629
Biological Process	GO:0030878	thyroid gland development	Ctns	IMP		Rat	PMID:35695380|RGD:155630629
Biological Process	GO:0008542	visual learning	Ctns	IMP	MGI:MGI:2388945	Mouse	PMID:17977621

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern